陈磊
- 教师名称：陈磊
- 教师拼音名称：Chen Lei
- 出生日期：1979-12-25
- 性别：男
- 职称：教授
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基本信息
研究方向
获奖情况
论文成果
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Dr. Chen received his Ph. D. in Microbiology in 2008, from Chinese Academy of Sciences. After graduating, he spent three years at Virginia Commonwealth University as a post-doc. In 2011, he returned to China and served as Associate Professor in School of Chemical Engineering and Technology, Tianjin University. Dr. Chen was promoted to full professor in 2018. His current research interest is mainly focused on the design and construction of photosynthetic cyanobacteria chassis. In the past five years, he has received 8 competitive grants as PI, with total amount of over 6,000,000 RMB, including those from the National Science Foundation of China, National Basic Research Program of China (“973” program) and so on. Dr. Chen has already published more than 100 SCI papers.
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- 23. Sun, T., Xu, L., Wu, L., Song, Z., Chen, L.*, Zhang, W. Identification of a new target slr0946 of the response regulator Sll0649 involving cadmium tolerance in Synechocystis sp. PCC 6803. Frontiers in Microbiology 2017, Accepted. doi: 10.3389/fmicb.2017.01582.2019
- 22. Sun, T., Chen, L.*, Zhang, W. Quantitative proteomics reveals potential crosstalk between a small RNA CoaR and a two-component regulator Slr1037 in Synechocystis sp. PCC6803. Journal of Proteome Research 2017, 16(8):2954-2963..2019
- 21. Gao, X., Sun, T., Wu, L., Chen, L.*, Zhang, W. Co-overexpression of response regulator genes slr1037 and sll0039 improves tolerance of Synechocystis sp. PCC 6803 to 1-butanol. Bioresource Technology 2017 May 4, doi: 10.1016/j.biortech.2017.04.112. [Epub ahead of print].2019
- 20. Chen, L., Ge, X., Wang, X., Patel, J.R., Xu, P. SpxA1 involved in hydrogen peroxide production, stress tolerance and endocarditis virulence in Streptococcus sanguinis. PLoS ONE 2012, 7(6): e40034. .2019
- 19. Chen, L., Zhu, Y., Song, Z., Wang, J., Zhang, W. An orphan response regulator Sll0649 involved in cadmium tolerance and metal homeostasis in photosynthetic Synechocystis sp. PCC 6803. Journal of Proteomics 2014, 103:87-102..2019
- 18. Chen, L., Wu, L., Zhu, Y., Song, Z., Wang, J., Zhang, W. An orphan two-component response regulator Slr1588 involves salt tolerance by directly regulating synthesis of compatible solutes in photosynthetic Synechocystis sp. PCC 6803. Molecular Biosystems 2014, 10(7):1765-1774. .2019
- 17. Ren, Q., Shi, M., Chen, L.*, Wang, J., Zhang, W. * Integrated proteomic and metabolomic characterization of a novel two-component response regulator Slr1909 involved in acid tolerance in Synechocystis sp. PCC 6803. Journal of Proteomics 2014, 109C:76-89. .2019
- 16. Zhu, Y., Pei, G., Niu, X., Shi, M., Zhang, M., Chen, L.*, Zhang, W*. Metabolomic analysis reveals functional overlapping of three signal transduction proteins in regulating ethanol tolerance in Synechocystis sp. PCC 6803. Molecular Biosystems 2015, 11(3):770-782. .2019
- 15. Niu, X., Zhu, Y., Pei, G., Wu, L., Chen, L.*, Zhang, W.* Elucidating butanol tolerance mediated by a response regulator Sll0039 in Synechocystis sp. PCC 6803 using a metabolomic approach. Applied Microbiology and Biotechnology 2015, 99(4):1845-1857. .2019
- 14. Zhang, Y., Niu, X., Shi, M., Pei, G., Zhang, X., Chen, L.*, Zhang, W.* Identification of a transporter Slr0982 involved in ethanol tolerance in cyanobacterium Synechocystis sp. PCC 6803 . Frontiers in Microbiology 2015, 6:487..2019
- 13. Yu, X., Niu, X., Zhang, X., Pei, G., Liu, J., Chen, L.*, Zhang, W. *Identification and mechanism analysis of chemical modulators enhancing astaxanthin acc umulation in Haematococcus pluvialis. Algal Research 2015, 11:284-293..2019
- 12. Gao, X., Sun, T., Pei, G., Chen, L.*, Zhang, W. Cyanobacterial chassis engineering for enhancing production of biofuels and chemicals. Applied Microbiology and Biotechnology 2016, 100(8), 3401-3413. .2019
- 11. Li, T., Zhang, Y., Shi, M., Pei, G. Chen, L.*, Zhang, W.* A putative magnesium transporter Slr1216 involved in sodium tolerance in cyanobacterium Synechocystis sp. PCC 6803. Algal Research, 2016, 17: 202-210. .2019
- 10. Zhang, Y., Pei, G., Chen, L.*, Zhang, W.* Metabolic dynamics of Desulfovibrio vulgaris biofilm grown on steel surface. Biofouling, 2016, 32(7):725-736..2019
- 9. Fu, Y., Chen, L.*, Zhang, W. Regulatory mechanisms related to biofuel tolerance in producing microbes. Journal of Applied Microbiology 2016, 121(2):320-332. .2019
- 8. Shi, M., Zhang, X., Pei, G., Chen, L.*, Zhang, W. Functional diversity of transcriptional regulators in the cyanobacterium Synechocystis sp. PCC 6803. Frontiers in Microbiology 2017, 8:280. .2019
- 7. Pei, G., Niu, X., Zhou, Y., Chen, L.*, Zhang, W. Crosstalk of two-component signal transduction systems in regulating central carbohydrate and energy metabolism during autotrophic and photomixotrophic growth of Synechocystis sp. PCC 6803. Integrative Biology 2017, 9(5):485-496. .2019
- 6. Li, X., Pei, G., Liu, L., Chen, L.*, Zhang, W. Metabolomic analysis and lipid accumulation in a glucose tolerant Crypthecodinium cohnii strain obtained by adaptive laboratory evolution. Bioresource Technology 2017, 235:87-95. .2019
- 5. Sun, T., Pei, G., Wang, J., Chen, L.*, Zhang, W.* A novel small RNA CoaR regulates coenzyme A biosynthesis and tolerance of Synechocystis sp. PCC6803 to 1-butanol possibly via promoter-directed transcriptional silencing. Biotechnology for Biofuels 2017, 10:42. .2019
- 4. Wang, Y., Chen, L.*, Zhang, W*. Proteomic and metabolomic analyses reveal metabolic responses to 3-hydroxypropionic acid synthesized internally in cyanobacterium Synechocystis sp. PCC 6803. Biotechnology for Biofuels 2016, 9:209. .2019
- 3. Chen, L., Wu L., Wang, J., Zhang, W. Butanol tolerance regulated by a two-component response regulator Slr1037 in photosynthetic Synechocystis sp. PCC 6803. Biotechnology for Biofuels 2014, 7:89. .2019
- 2. Song, Z., Chen, L.*, Wang, J., Lu, Y., Jiang, W., Zhang, W.* A transcriptional regulator Sll0794 regulates tolerance to biofuel ethanol in photosynthetic Synechocystis sp. PCC 6803. Molecular & Cellular Proteomics 2014, 13(12):3519-3532..2019
- 1. Zhu, H., Ren, X., Wang, J., Song, Z., Shi, M., Qiao, J., Tian, X., Liu, J., Chen, L.*, Zhang, W. Integrated OMICS guided engineering of biofuel butanol-tolerance in photosynthetic Synechocystis sp. PCC 6803. Biotechnology for Biofuels 2013, 6(1):106. .2019
教育经历
- 2003.9-2008.7 Shanghai Institutes for Biological Sciences, CAS Microbiology 博士
- 1999.9-2003.7 Shandong University Biological Science 学士
工作经历
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2011.9 -2020.4
|School of Chemical Engineering and Technology|Tianjin University, China|Professor
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2008.10 -2011.8
|Virginia Commonwealth University, USA|Postdoc