School of Life Sciences
13662113599
liuduo19870401@126.com
No. 92, Weijin Road, Nankai District, Tianjin, P.R.China
300072
Liu Duo, an associate researcher at the School of Life Sciences, Tianjin University. He has undertaken 2 national key R & D projects / sub-projects, 1 natural Science Foundation youth project, and participated in 1 natural Science Foundation emergency management project, 1 international cooperation project and 1 general program project. He has obtained achievements in genome synthesis, DNA assembly methods, and cell factory construction. He has established oligonucleotide linker-assisted multigene assembly and library construction strategy, established heterologous multigene assembly integration strategy in oleaginous yeast , and he is the module assembly technology head involved in the construction of Tianjin university synthetic biological elements module library SynbioML@TJU. He has constructed the yeast cells for production of carotenoids, violobactericin, caffeic acid, resveratrol. He has published a series of papers as first author / corresponding author in Chemical Society Reviews, ACS Synthetic Biology, Biotechnology for Biofuels, Microbial Cell Factories etc.
- Doctoral degree| Tianjin University| Biochemical Engineering| 2017
- Bachelor’s Degree| Tianjin University| Biological Engineering| 2009
- Synthetic biology strategies to modify cells for medical therapy direction:
(1) Synthetic genomics: design, synthesis, assembly, transfer and functional reconstruction of large segments of the genome, establish relevant key technologies, and study the disease mechanism and treatment. - (2) Synthetic cell factory: engineer the yeast genome, establish the synthetic pathways of natural products such as terpenoids, flavonoids, caffeic acid phenylamine and other drug precursors with anti-inflammatory and antitumor activities, and build a drug production cell factory.
- (3) Synthetic cell diagnosis and treatment: transform tool cells for disease sensing, diagnosis and treatment.
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2021.12-Now
School of Life Sciences | Tianjin University | Associate Professor  -
2017.5-2021.11
School of Chemical Engineering and Technology | Tianjin University | lecturer 
- Papers
- [1] Constructing Yeast Chimeric Pathways To Boost Lipophilic Terpene Synthesis
- [2] Engineering global transcription to tune lipophilic properties in Yarrowia lipolytica
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- [3] Multigene Pathway Engineering with Regulatory Linkers (M-PERL)
- [4] Engineering the Biosynthesis of Caffeic Acid in Saccharomyces cerevisiae with Heterologous Enzyme Combinations
- [5] Engineering yeast artificial core promoter with designated base motifs
- [6] Design and chemical synthesis of eukaryotic chromosomes
- [7] Engineered biosynthesis of natural products in heterologous hosts
- [8] Profiling influences of gene overexpression on heterologous resveratrol production in Saccharomyces cerevisiae
- [9] SCRaMbLE drive application of synthetic yeast genome
- [10] Bug mapping and fitness testing of chemically synthesized chromosome X
- [11] In vitro DNA SCRaMbLE
- [12] Precise control of SCRaMbLE in synthetic haploid and diploid yeast