ChenLei
School
School of Pharmaceutical Science and Technology
Professional Title
Associate professor
Discipline
Separation and Analysis Technology, Genomics & Proteomics
Contact Information
022-27403650
chenlei@tju.edu.cn
Room A407, Building 24, Tianjin University
300072
Education Background
- Doctor| Tianjin University, China| Applied Chemistry,| 2006
Research Interests
- exploitation of magnetic separation technology in the purification of biological samples
- b) investigation into the hydrolysis and condensation mechanism of hybrid silica based materials using MS
- a) development of different methods to control the morphology and pore structure of the HPLC stationary phase
Positions & Employments
-
2013.10-2014.10
 UCSB,USA | Visiting Scholar  -
2006.6-Now
 SPST,Tianjin Univ. | Associate Professor 
Academic Achievements
- Papers
- [1] Hui Bai, Yinan Zhao, Lei Chen*. Single-column analysis strategy of star hydroxypropyl cyclodextrin polymer chiral stationary phase to the simultaneous separation of three-pair chiral alkaloid enantiomers. Talanta 2025. 295, 128369, https://doi. org/10.1016/j.talanta.2025.128369.
- [2] Hui Bai, Lei Chen*. Stereoisomeric separation and chiral recognition mechanism study of star cyclodextrin polymer as the chiral stationary phase. Analytica Chimica Acta 2024. 1329, 343249, https://doi. org/10.1016/j.aca.2024.343249.
-
- [3] Chang Chaoqun, Jin Xinghua, Bai Hui, Zhang Fan, Lei Chen*. Molecular dynamics simulation for the acidic compounds retention mechanism study on octyl-quaternary ammonium mixed-mode stationary phase. Journal of Chromatographic Science 2024, 62(10): 962-971, https://doi.org/10.1093/chromsci/bmae036.
- [4] Chongdi Qi, Lei Chen*. Progress of ligand‑modified agarose microspheres for protein isolation and purification. Microchimica Acta 2024, 191:149, https://doi.org/10.1007/s00604-024-06224-4.
- [5] Xindi Li, Xiaojuan Deng, Lei Chen*. Sunflower‑like missing‑linker covalent organic framework for efficient extraction of non‑steroidal anti‑inflammatory drugs. Environmental Science and Pollution Research 2024, 31: 16601-16612, https://doi.org/10.1007/s11356-024-32312-2.
- [6] Xu Guo, Hui Bai, Lei Chen*. Imidazole-octyl mixed-mode stationary phase based on macroporous silica for purification of ovomucoid and ovotransferrin. Microchimica Acta 2023, 190: 404, https://doi.org/10.1007/s00604-023-05986-7.
- [7] Lixuan Zhang, Xindi Li , Lei Chen*. Fabrication of mixed-mode amphoteric β-cyclodextrin polymer for the simultaneous extraction of acidic and alkaline drugs. Journal of Chromatography B 2023, 1228, 123833, https://doi.org/10.1016/j.jchromb.2023.123833.
- [8] Yao Jing, Xu Guo, Congdi Qi, Lei Chen*. Fabrication of silica microspheres for HPLC packing with narrow particle size distribution and different pore sizes by hard template method for protein separation. Chromatographia 2022, 85, 985–995, https://doi.org/10.1007/s10337-022-04200-9.
- [9] Jinjin Shi, Lixuan Zhang, Zhixia Huo, Lei Chen*. High stability amino-derived reversed-phase/anion-exchange mixed-mode phase based on polysilsesquioxane microspheres for simultaneous separation of compound drugs. Journal of Pharmaceutical and Biomedical Analysis 2021, 203, 114187, https://doi.org/10.1016/j.jpba.2021.114187.
- [10] Hui Bai, Lei Chen*. Simultaneous separation of atenolol enantiomers and its acid/alkaline degradation impurities on mixed-mode chiral ligand exchange stationary phases. Chirality 2021, 33, 710-721, https://doi. org/10.1002/chir.23353.
- [11] Ruiting Bai, Chaoqun Chang, Lei Chen*. Preparation of highly responsive monodisperse magnetic porous silica microspheres for the enrichment of cephalosporins in wastewater. Journal of separation Science. 2020, 43, 3765-3774, https://doi.org/10.1002/jssc.202000589.
- [12] Zhixia Huo, Qianhong Wan, Lei Chen*. Energy-efficient and environment-friendly method to prepare monodispersed silica stationary phases for simultaneous separation of compound drugs. Journal of Chromatography A. 2020,1618, 460866, https://doi.org/10.1016/j.chroma.2020.460866.
- [13] Zhixia Huo, Lei Chen*. Base-deactivated and alkaline-resistant chromatographic stationary phase based on functionalized polymethylsilsesquioxane microspheres. Journal of separation Science. 2020, 43, 389-397, https://doi.org/10.1002/jssc.201900634.
- [14] Fan Zhang, Lei Chen*. Synthesis of octyl-quaternary ammonium mixed-mode stationary phase by vapor deposition approach and its application in compound preparation separation. Chromatographia. 2019, 82, 1437-1447, https://doi.org/10.1007/s10337-019-03774-1.
- [15] Yan Li, Shuanghong Zhang, Lei Chen*. An amino endcapped octadecylsilane silica-based mixed-mode stationary phase for the simultaneous separation of neutral and ionizable components in fixed-dose combinations. Analytical Methods, 2019,11, 3898-3909, https://doi.org/10.1039/C9AY00660E.
- [16] Yan Li, Lei Chen*. Separation and identification of oligomeric hindered amine light stabilizer uvasorb HA 88 by high-performance liquid chromatography (HPLC) coupled with matrix-assisted laser desorption/ ionization time-of-flight mass spectrometry (MALSI-TOF-MS). Analytical Letters, 2019, 52(16), 2546-2561, https://doi.org/10.1080/00032719.2019.1617731.
- [17] Zhixia Huo, Qianhong Wan, Lei Chen*. Synthesis and evaluation of porous polymethylsilsesquioxane microspheres as low silanol activity chromatographic stationary phase for basic compound separation. Journal of Chromatography A. 2018,1553, 90-100, https://doi.org/10.1016/j.chroma.2018.04.024.
- [18] Meng Chen, Lei Chen*. A novel high hydrothermal stability aminofunctionalized stationary phase prepared by a vapour deposition method. Analytical Methods. 2018, 10, 1538-1546, https://doi.org/10.1039/C8AY00133B.
- [19] 王晓欢,陈磊*. 碱性药物在硫醚嵌入苯磺酸硅胶固定相上的色谱行为. 色谱2018, 36(9), 850-857.
- [20] Li, Jun, Lei Chen*. Monitoring structural evolution of organosilicate species during sol-gel processes by electrospray ionization mass spectrometry. Rapid Communications in Mass Spectrometry. 2016, 30, 504-510, https://bfbic99950304871e4f82s5oqnp0poqoow6pq6fiac.eds.tju.edu.cn/doi/10.1002/rcm.7461#.
- [21] 方秋雪,刁兴利,万谦宏,陈磊*. 顶空气相色谱法测定瑞替加滨原料药中残留溶剂, 分析测试学报2013, 32(3), 308-313.
- [22] Xianhua Wang, Qiuxue Fang, Shipeng Liu, Lei Chen*.The application of pseudo template molecularly imprinted polymer to the solid-phase extraction of cyromazine and its metabolic melamine from egg and milk. Journal of Separation Science. 2012, 35, 1432-1438, https://bfbiz1b13095ec5284139s5oqnp0poqoow6pq6fczx.eds.tju.edu.cn/10.1002/jssc.201200096.
- [23] Xianhua Wang, Qiuxue Fang, Shipeng Liu, Lei Chen*. Preparation of magnetic molecularly imprinted polymer with pseudo template for rapid simultaneous determination of cyromazine and melamine in bio-matrix samples. Analytical and Bioanalytical Chemistry. 2012, 404, 1555-1564, https://bfbic1b13095ec5284139s5oqnp0poqoow6pq6fiac.eds.tju.edu.cn/10.1007/s00216-012-6200-7.
- [24] 刘帅,陈磊*. 以廉价硅源制备多孔二氧化硅微球及其孔结构的控制,硅酸盐通报2012,31(3),669-674.
- [25] 潘恩磊,陈磊*. 新型硅胶基质强阴离子交换填料的制备及表征. 光谱实验室 2012, 29(6), 3711-3716.
- [26] 田爽,王秋玲,陈磊*. 溶胀法制备高强度聚苯乙烯荧光及编码微球. 应用化工 2012, 41(5), 859-866.
- [27] 郭志强,陈峰,邓怡,万谦宏,陈磊*. 原子层沉积法制备巯丙基硅胶及其对溶液中钯(II)离子的吸附行为. 高等学校化学学报 2009, 30(10), 2017-2023.
- [28] Zhi-Qiang Guo, Dan Xu, Qian-Hong wan, Lei Chen*. Separation of dihydroergotoxine on polar- embedded reversed-phase stationary phase. Chinese Journal of Analytical Chemistry 2009, 37(2), 232-236.
- [29] 陈磊,王宏玲,万谦宏*. 磁场辅助毛细管电色谱.中国科学 B 辑:化学. 2009, 39(8), 728-732.
- [30] Hongling Wang, Jingjing Cao, Yanping Bi, Lei Chen*, Qian-Hong Wan∗. Magnetically immobilized frits for the preparation of packed columns used in capillary electrochromatography. Journal of Chromatography A. 2009, 1216 (31), 5882-5887, (Co-corresponding author), https://doi.org/10.1016/j.chroma.2009.06.017.
- [31] 陈磊, 万谦宏*. 雌马醇对映体的高效液相色谱分离, 药物分析杂志, 2006, 26(6), 795-798.
- [32] 陈磊, 万谦宏*. Beta-氨基酸对映体在涂覆型手性配体交换色谱固定相上的分离, 分析化学, 2006, 34(4), 474-478.
- Patents
- [1] Qianhong Wan, Lei Chen, Wenbin Li, Zhichao Zhang. A preparation method for ferromagnetic urea-formaldehyde resin. 2003-7-21, Chinese, ZL 03 1 30423.0
- [2] Qianhong Wan, Lei Chen, Zhichao Zhang, Wenbin Li. A preparation method for ferromagnetic porous silica microspheres. 2003-7-21, Chinese, ZL 03 1 30422.2
-
- [3] Lei Chen, Guiying Jia, Qianhong Wan. Method for preparing monodisperse hybrid silica gel microspheres through self-hydrolysis of methoxy-organosilane. 2017-7-28, Chinese, ZL 2015 1 0178500.9
- [4] Lei Chen, Yuting Jiang, Qianhong Wan. Porous organic-inorganic hybridization silicon microsphere preparation method. 2017-5-10, Chinese, ZL 2015 1 0216610.X
- [5] Qianhong Wan, Shipeng Liu, Xiuli Zhou, Zhixia Huo, Xiaohuan Wang, Ruisha Li, Lei Chen. Preparation method of porous spherical silica gel chromatography packing material. 2018-9-18,Chinese,CN201610578289.4.
- [6] Qianhong Wan, Zhixia Huo, Lei Chen. A preparation method for monodispersed porous silica microspheres. 2020-3-31, Chinese, ZL 201810423795.5
- [7] Qianhong Wan, Shuanghong Zhang, Lei Chen. Preparation and applications of reversed-phase/ion-exchange mixed-mode chromatography stationary phase. 2021-11-5,Chinese, ZL2019 1 0238170.6.
- [8] Lei Chen, Zhixia Huo, Qianhong Wan. Micron-scale monodispersed porous silica microsphere and its preparation method. 2022-1-11, Chinese, ZL 201811335507.7