Journal:JACS
Abstract:Posttranslational modifications (PTMs) of lysine are crucial histone marks that regulate diverse biological processes. The functional roles and regulation mechanism of many newly identified lysine PTMs, however, remain yet to be understood. Here we report a photoaffinity crotonyl lysine (Kcr) analogue that can be genetically and site-specifically incorporated into histone proteins. This, in conjunction with the genetically encoded photo-lysine as a “control probe”, enables the capture and identification of enzymatic machinery and/or effector proteins for histone lysine crotonylation.
All the Authors:X. Xie,# X. Li,# F. Qin,# X. Li*, and P. Chen*
First Author:X. Xie,# X. Li,# F. Qin,# X. Li*, and P. Chen*
Correspondence Author:Xiang David Li,* and Peng R. Chen*
Volume:139
Issue:19
Page Number:6522-6525
Translation or Not:no
CN No.:null
Date of Publication:2017-05-01