Temperature insensitive prediction of glucose concentration in turbid medium using multivariable calibration based on external parameter orthogonalization

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Affiliation of Author(s):Tianjin University

Teaching and Research Group:Bio optics and Applied Spectroscopy Laboratory

Journal:Proc. SPIE, Optics in Health Care and Biomedical Optics VII

Place of Publication:America

Funded by:New Hemanalysis Instrument-Noninvasive Blood Glucose Detector（新型血液分析仪器—无创血糖检测仪）

Key Words:Near-infrared Spectroscopy；Multivariable Calibration；emperature Correction；Diffuse Spectra

Abstract:The measurement accuracy of non-invasive blood glucose concentration (BGC) sensing with near-infrared spectroscopy is easily affected by the temperature variation in tissue because it would induce an unacceptable spectrum variation and the consequent prediction deviation. We use a multivariable correction method based on external parameter orthogonalization (EPO) to calibrate the spectral data recorded at different temperature values to reduce the spectral variation. The tested medium is a kind of tissue phantom, the Intralipid aqueous solution.

All the Authors:Han Tongshuai、Zhang Ziyang、Sun Cuiying、Sun Di、Guo Chao、Liu Jin

First Author:Han Tongshuai

Indexed by:Applied Research

Correspondence Author:Liu Jin

Volume:10024

Translation or Not:no