Qiao Jian jun
School

School of Chemical Engineering and Technology

Professional Title

Professor

Contact Information

jianjunq@tju.edu.cn

Brief Introduction


I join Tianjin university at July 1 2001. I have a fascination with the secret of bacteria. How can bacteria resist different kinds of enviromental stress?To conquer the enviromental stress, bacteria evolved many different ways to survive. They can produce antibiotic, they can synthesis cell wall, they can produce spore. But the further question is, How can bacteria produce antibiotics? How are cell wall synthesized? How are spore synthesized? and How these survival methods are regulated as a whole. Fortunately, I get some grants to investigate the mechanism of these phenomena. By using the method of system biology, synthetic biology, some interesing regulation mechanism are being revealed, but still there is a long way to go. 

First of all. I focusd on the understanding and reconstructing of the acid tolerant system of L.lactis. By using genome sequencing, transcriptomic approach, proteomic analysis, sRNA sequencing, protein expression, gene deletion, EMSA, several regulator proteins and sRNA were screened with the efficient capacity of acid tolerance and the mechanisim of their regulation were revealed. Several strains of L. lactis with higher acid tolerant capacity and nisin yield were constructed. 

Some intersting reglutor and sRNA on the regulation of cell wall or spore also have been revealed, the machanism is studied now.

The biosynthetic route of some natural products have been revealed and reconstructed by using synthetic biology, more details are investigated;

Welcome young talents join our group to find novel mechanism of microbe world.


Publications:

  1. Wang binbin, Zhang huawei, Qiao Jianjun* j dairy science. accepted

  2. Liu J, Zhou J, Wang L, Ma Z, Zhao G, Ge Z, Zhu H, Qiao J*.  Improving nitrogen source utilization from defatted soybean meal for nisin production by enhancing proteolytic function of Lactococcus lactis F44. Sci Rep. 2017 Jul 21;7(1):6189. doi: 10.1038/s41598-017-06537-w.

  3. Qi J, Caiyin Q, Wu H, Tian K, Wang B, Li Y, Qiao J*.  The novel sRNA s015 improves nisin yield by increasing acid tolerance of Lactococcus lactis F44. Appl Microbiol Biotechnol. 2017 Aug;101(16):6483-6493. doi: 10.1007/s00253-017-8399-x. Epub 2017 Jul 9.

  4. Tang ZK, Li XM, Pang AP, Lin CY, Zhang Y, Zhang J, Qiao J*, Zhao GR*.  Characterization of three pathway-specific regulators for high production of monensin in Streptomyces cinnamonensis. Appl Microbiol Biotechnol. 2017 Aug;101(15):6083-6097. doi: 10.1007/s00253-017-8353-y. Epub 2017 Jul 7.

  5. Hao P, Liang D, Cao L, Qiao B, Wu H, Caiyin Q, Zhu H, Qiao J*.  Promoting acid resistance and nisin yield of Lactococcus lactis F44 by genetically increasing D-Asp amidation level inside cell wall. Appl Microbiol Biotechnol. 2017 Aug;101(15):6137-6153. doi: 10.1007/s00253-017-8365-7. Epub 2017 Jun 22.

  6. Liu J, Ma Z, Zhu H, Caiyin Q, Liang D, Wu H, Huang X, Qiao J*.  Improving xylose utilization of defatted rice bran for nisin production by overexpression of a xylose transcriptional regulator in Lactococcus lactis. Bioresour Technol. 2017 Aug;238:690-697. doi: 10.1016/j.biortech.2017.04.076. Epub 2017 Apr 22.

  7. Ruan HH, Zhang Z, Wang SY, Nickels LM, Tian L, Qiao JJ*, Zhu J*. Tumor Necrosis Factor Receptor-Associated Factor 6 (TRAF6) Mediates Ubiquitination-Dependent STAT3 Activation upon Salmonella enterica Serovar Typhimurium Infection. Infect Immun. 2017 Jul 19;85(8). pii: e00081-17. doi: 10.1128/IAI.00081-17. Print 2017 Aug.

  8. Xie ZX, Li BZ, Mitchell LA, Wu Y, Qi X, Jin Z, Jia B, Wang X, Zeng BX, Liu HM, Wu XL, Feng Q, Zhang WZ, Liu W, Ding MZ, Li X, Zhao GR, Qiao JJ, Cheng JS, Zhao M, Kuang Z, Wang X, Martin JA, Stracquadanio G, Yang K, Bai X, Zhao J, Hu ML, Lin QH, Zhang WQ, Shen MH, Chen S, Su W, Wang EX, Guo R, Zhai F, Guo XJ, Du HX, Zhu JQ, Song TQ, Dai JJ, Li FF, Jiang GZ, Han SL, Liu SY, Yu ZC, Yang XN, Chen K, Hu C, Li DS, Jia N, Liu Y, Wang LT, Wang S, Wei XT, Fu MQ, Qu LM, Xin SY, Liu T, Tian KR, Li XN, Zhang JH, Song LX, Liu JG, Lv JF, Xu H, Tao R, Wang Y, Zhang TT, Deng YX, Wang YR, Li T, Ye GX, Xu XR, Xia ZB, Zhang W, Yang SL, Liu YL, Ding WQ, Liu ZN, Zhu JQ, Liu NZ, Walker R, Luo Y, Wang Y, Shen Y, Yang H, Cai Y, Ma PS, Zhang CT, Bader JS, Boeke JD, Yuan YJ. "Perfect" designer chromosome V and behavior of a ring derivative. Science. 2017 Mar 10;355(6329). pii: eaaf4704. doi: 10.1126/science.aaf4704.


Education Background
  • Doctoral degree| Tianjin University of Science & Technology| microbiology| 2001
  • Master’s Degree| Inner Mongolia University| microbiology| 1998
  • Bachelor’s Degree| Inner Mongolia University| microbiogly| 1995
Research Interests
  • Synthetic microbiology
    (1) Understand and construct novel biosynthetic route of natural products by using synthetic biology, and improve  their yield;
    (2) Understand and reconstruct acid-tolerant regulation system, well wall and spore
Positions & Employments
  • 2013.3-2015.3

     Natinal Natural Science Foundation of China | Director of Microbiology department 
  • 2006.5-2006.8

     GBF-Gesellschaft fur Biotechnologische for schung mbH | Visiting scholar 
  • 2005.5-2005.8

     GBF-Gesellschaft fur Biotechnologische for schung mbH | Visiting scholar 
  • 2014.7-2019.12

     Tianjin University | Professor 
  • 2003.4-2014.7

     Tianjin University | Associate Professor 
  • 2001.9-2003.9

     Tianjin University | Postdoctor 
Academic Achievements
Team
Key Laboratory of Systems Bioengineering, Ministry of Education