Rajavel Srinivasan
School
School of Pharmaceutical Science and Technology
Professional Title
Associate professor
Contact Information
022-27401021
rajavels@tju.edu.cn
Room 506, Building 24, Tianjin University
Education Background
- Postdoctoral| University of Cambridge, United Kingdom| 2019
- Ph. D. | National University of Singapore, Singapore| 2019
Research Interests
- 2) Inhibitor discovery based on fragment-based approaches: Design and synthesis of ‘unconventional’ fragments with rich structural diversity. These fragments will be used as a starting point towards novel inhibitors for unexplored biological targets such as the AurB-INCENP interaction.
- aiming at advancing the way organic molecules are made for drug discovery and chemical biology applications.
- The research in the group of Srinivasan encompasses two main areas, 1) Developing new reaction methodologies: The research topics under this area include bioorthogonal reactions, late-stage modification of advanced chemical entities, C-H activation, and high-throughput amenable synthesis –
Positions & Employments
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2019.12-2019.12
Singapore's Agency for Science, Technology, and Research, ICES | Scientist I
Academic Achievements
- Books
- [1] Srinivasan, R.; Coyne, A. G.; Abell, C. Regioselective Conversion of Arenes to N-aryl-1,2,3-triazoles Using C-H Borylation. Chem. Eur. J. 2014, 20, 11680.
- [2] Sinivasan, R.; Tan, L. P.; Wu, H.; Yang, P.-Y.; Kalesh, K. A.; Yao, S. Q. High-Throughput Synthesis of Azide Libraries Suitable for Direct “Click”Chemistry and in situ Screening. Org. Biomol. Chem. 2009, 7, 1821.
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- [3] Srinivasan, R.; Tan, L. P.; Hao, W.; Yao, S. Q. Solid-Phase Assembly and in situ Screening of Protein Tyrosine Phosphatases inhibitors. Org. Lett. 2008, 10, 2295.
- [4] Srinivasan, R.; Li, J.; Ng, S. L.; Kalesh, K. A.; Yao, S. Q. Methods of Using Click Chemistry in the Discovery of Enzyme Inhibitors. Nature Protocols 2007, 2, 2655.
- [5] Srinivasan, R.; Uttamchandani, M.; Yao, S. Q. Rapid Assembly and In Situ Screening of Bidentate Inhibitors of Protein Tyrosine Phosphatases (PTPs). Org. Lett. 2006, 8, 713.
- Honors & Awards
- [1] TOP Graduate Researcher - Faculty of Science, National University of Singapore, Singapore, 2007
- [2] Best Graduate Researcher - Department of Chemistry, National University of Singapore, Singapore 2007
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- [3] TOP Graduate Researcher - Faculty of Science, National University of Singapore, Singapore, 2007
- [4] Best Graduate Researcher - Department of Chemistry, National University of Singapore, Singapore 2007
- [5] TOP Graduate Researcher - Faculty of Science, National University of Singapore, Singapore, 2007
- [6] Best Graduate Researcher - Department of Chemistry, National University of Singapore, Singapore 2007