Youcai Zhang
School
School of Pharmaceutical Science and Technology
Professional Title
Professor
Discipline
Pharmacology and Toxicology
Contact Information
022-87401830
youcai.zhang@tju.edu.cn
Room A506, Building 24, Tianjin University
Research Interests
- 3) establishment of novel preclinical models to improve the prediction of drug-induced liver injury
- 2) investigation of the role of intestinal microbiota in lipid metabolism;
- 1) preclinical development of novel transporter/receptor-targeted drugs for metabolic diseases;
Academic Achievements
- Books
- [1] Zhang Y.; Limaye P. B.; Renaud, H. J.; Klaassen C. D. Effect of various antibiotics on modulation of intestinal microbiota and bile acid profile in mice. Toxicol. Appl. Pharmacol. 2014, 277, 138.
- [2] Zhang Y.; Csanaky I. L.; Selwyn F. P.; Lehman-McKeema, L. D.; Klaassen C. D. Organic anion transporting polypeptide 1a4 is important for secondary bile acid metabolism. Biochem. Pharmacol. 2013, 86, 437.
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- [3] Zhang Y.; Hong J. Y.; Rockwell C. E.; Copple B.; Jaeschke H.; Klaassen C. D. Effect of bile duct ligation on bile acid metabolism and liver toxicity in mice. Liver Internat. 2012, 32, 58.
- [4] Zhang Y.; Csanaky I. L.; Lehman-McKeeman L. D.; Klaassen C. D. Loss of organic anion transporting polypeptide 1a1 increases deoxycholic acid hepatotoxicity in mice by increasing intestinal permeability. Toxicol. Sci. 2011, 124, 251.
- [5] Zhang Y.; Klaassen C. D. Effects of feeding bile acids and a bile acid sequestrant on hepatic bile acid composition in mice. J. Lipid Res. 2010, 51, 3230.