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工作经历

· 2022.2- 至今

Instrumental Analysis Center → SPST Tianjin University → Engineer

研究方向

· 在国际上首次发现并报道了广泛存在于肠道菌群中的尿酸还原降解途径及关键中间代谢物2,8-二氧嘌呤；Pioneered the discovery of the widespread uric acid reductive degradation pathway in anaerobic bacteria, revealing the key intermediate 2,8-dioxopurine

个人简介

在国际上首次发现并报道了广泛存在于肠道菌群中的尿酸还原降解途径及关键中间代谢物2,8-二氧嘌呤；Pioneered the discovery of the widespread uric acid reductive degradation pathway in anaerobic bacteria, revealing the key intermediate 2,8-dioxopurine

学术成果

论文成果

[1]A reductive uric acid degradation pathway in anaerobic bacteria. Life Metabolism, loaf031, https://doi.org/10.1093/lifemeta/loaf031
[2]A widespread pathway for substitution of adenine by diaminopurine in phage genomes. Science. DOI: 10.1126/science.abe488
[3]A Widespread Radical-Mediated Glycolysis Pathway. J Am Chem Soc. 2024 DOI: 10.1021/jacs.4c07718. https://doi.org/10.1021/jacs.4c07718
[4]Anaerobic purinolytic enzymes enable dietary purine clearance by engineered gut bacteria. Cell Chemical Biology. https://doi.org/10.1016/j.chembiol.2023.04.008
[5]Development of an efficient insecticide substrate and inhibitor screening system of insect P450s using fission yeast. Insect Biochemistry and Molecular Biology. https://doi.org/10.1016/j.ibmb.2023.103958
[6]Study of sulfoglycolysis in Enterococcus gilvus reveals a widespread bifurcated pathway for dihydroxypropanesulfonate degradation. iScience. 2024 DOI: 10.1016/j.isci.2024.111010
[7]Nanoparticle conjugation of ginsenoside Rb3 inhibits myocardial fibrosis by regulating PPAR alpha pathway. BIOMEDICINE & PHARMACOTHERAPY. 10.1016/j.biopha.2021.111630
[8]Combined virtual and experimental screening of multicomponent crystals of 2,4-dichlorophenoxyacetic acid. New J. Chem.DOI: 10.1039/d2nj00536k
[9]Electron-Accepting Micelles Deplete Reduced Nicotinamide Adenine Dinucleotide Phosphate and Impair Two Antioxidant Cascades for Ferroptosis-Induced Tumor Eradication. ACS Nano. https://doi.org/10.1021/acsnano.0c00764

李骘

工作经历

· 2022.2- 至今

研究方向

个人简介

学术成果

论文成果