天津大学教师个人主页系统 Mario Andrea Marchis Home Home

Mario Andrea Marchis

School

School of Pharmaceutical Science and Technology

Professional Title

Associate professor

Contact Information

15846331344

Mario@tju.edu.cn

Building 24

Education Background

Research Interests

Overall, building genetic biosensors demands a proper characterization of its basic components and the optimization of mechanisms for the regulation, in yeast, of transcription and translation processes. These are two important research directions in my Synthetic Biology lab.
Biosensors designed on the computer are implemented in my lab into the yeast S. cerevisiae. Yeast is the simplest eukaryotic organism and, as such, a perfect candidate to develop theoretical models and build biosensors that might be used later into more complex hosts such as mammalian cell
Biosensors detect one or more chemicals (inputs) in the cellular environment and, as a response, trigger the production of a clear output signal (e.g. fluorescence) or the activation of a pathway that establishes an interaction between the cells and the sensed chemicals.
On the computational side I am working on the development of a stand-alone piece of software for the design of biosensors in living cells.
Research in Synthetic Biology is both theoretical and applied. Circuits are first designed on the computer. They are associated with mathematical models such that simulations can drive their wet-lab implementation.
Synthetic Biology is referred to as Life Engineering since it aims at modifying cells with the insertion of DNA circuits that carry out new, specific tasks. Possible applications are diagnostics, cure of disease, biofuel production, and environmental care.

Positions & Employments

2013.1-2018.1

Harbin Institute of Technology | Associate Professor in Synthetic Biology
2003.1-2007.12

CILEA (Italy) | Analyst programmer

Academic Achievements