Prof. Guangwei Wang obtained his Bachelor’s degree from Lanzhou University in 1998. After working at Shanghai Institute of Organic Chemistry (SIOC), he moved to Purdue University in 2004 to pursue his Ph.D. degree under the guidance of Prof. Ei-ichi Negishi (2010 Nobel Prize Laureate). His Ph.D. research work mainly focused on the study towards Pd-catalyzed cross-coupling and Zr-catalyzed carboalumination and their application in natural product synthesis. After two-years’ postdoc in the same group, he came back to Shanghai in 2011 and joined UniTris Biopharma for process study of generic drugs. In 2014, he moved to Tianjin University and to start his independent research career. The current reasearch focues on the transition metal catalyzed transforamtions including copper catalyzed carboboration, difluoroalkylation of unsaturated compounds, and pyridium salts related transformations.

• Transition metal catalyzed carbometalation
• Synthesis of fluorine-containing compounds
• Total synthesis of natural products

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• Chen, H.; Yang, Y.; Wang, L.; Niu, Y.; Guo, M.; Zhao, W.; Tang, X.; Wang, G. Slicing and Splicing of Bromodifluoro-N-arylacetamides: Dearomatization and Difunctionalization of Pyridines. Org. Lett. 2020, 22, in press. DOI: 10.1021/acs.orglett.0c02368
• Sun, Z.-Y.; Zhou, S..; Yang, K.; Guo, M.; Zhao, W.; Tang, X.; Wang, G.* Tetrahydroxydiboron-Promoted Radical Addition of Alkynols. Org. Lett. 2020, 22, 6214-6219. DOI: /10.1021/acs.orglett.0c02367
• Ma, N.; Wang, G.*;Zhang, W.* Explanation of “Nomenclature of Organic Compounds-2017”: Comparison of Nomenclature Rules and Nomenclature of Common Substituent Groups. Univ. Chem. 2019, 34, 116−120.
• Zhu, X.; Zhang, Y.; Ren, X.; Yao, J.; Guo, S.; Zhang, L.; Wang, D.; Wang, G.; Zhang, X.; Li, R.;* Hu, W. 2D Molecular Crystal Bilayer p–n Junctions: A General Route toward High-Performance and Well-Balanced Ambipolar Organic Field-Effect Transistors. Small 2019, 1902187. DOI: 10.1002/smll.201902187
• Zhao, S.; Wang, X.; Wang, P.; Wang, G.*; Zhao, W.; Tang, X.;* Guo, M.* BF3•OEt2‑Promoted Propargyl Alcohol Rearrangement/[1,5]-Hydride Transfer/Cyclization Cascade Affording Tetrahydroquinolines. Org. Lett. 2019, 21, 3990-3993. DOI: 10.1021/acs.orglett.9b01153
• Yang, Y.; Yuan, F.; Ren, X.; Wang, G.*; Tang, X.; Zhao, W.; Guo, M.* Copper-Catalyzed Oxydifluoroalkylation of Unsaturated Alcohols. J. Org. Chem. 2019, 84, 4507−4516. DOI: 10.1021/acs.joc.9b00121
• Dai, Q.; Zhao, H.;* Cao, H.; Yang, J.; Zhao, W.; Wang, T.;* Liu, L.; Fan, Z.; Wang, G. Photo-triggered conversion of hydrophilic fluorescent biomimetic nanostructures for cell imaging. Chem. Commun. 2019, 55, 596-599. DOI: 10.1039/c8cc07197g
• Zhou, S.; Yuan, F.; Guo, M.; Wang, G.*; Tang, X.; Zhao, W.* Switchable synthetic strategy toward trisubstituted and tetrasubstituted exocyclic alkenes. Org. Lett. 2018, 20, 6710-6714. DOI: 10.1021/acs.orglett.8b02814.2019
• 41. Yuan, F.; Zhou, S.; Yang, Y.; Guo, M.; Tang, X.; Wang, G.* Copper Catalyzed One-Pot Difluoroalkylation and Lactonization of Unsaturated Carboxylic Acids. Org. Chem. Front. 2018, 5, asap. DOI: 10.1039/C8QO00940F.2019
• 40. Wang, X.; Liu, J.; Yu, Z.; Guo, M.; Tang, X.; Wang, G.* Desulfonylation-Initiated Distal Alkenyl Migration in Copper-Catalyzed Alkenylation of Unactivated Alkenes. Org. Lett. 2018, 20, asap. DOI: 10.1021/acs.orglett.8b02840.2019
• 39. Dai, Q.; Zhao, H.;* Fan, Z.; Zhao, W.; Wang, G.;* Zhang, J.; Hou, R.; Du, P.; Cao, H.* In Situ Nanoreactors: Controllable Photoluminescent Carbon-Rich Polymer Nanodots Derived from Fatty Acid under Photoirradiation. Macromol. Rapid Commun. 2018, 39, 1800152. DOI: 10.1002/marc.201800152.2019
• 38. Feng, X.; Wang, X.; Chen, H.; Tang, X.; Guo, M.; Zhao, W.;* Wang, G.* Copper-Mediated Regioselective Hydrodifluoroalkylation of Alkynes. Org. Biomol. Chem., 2018, 16, 2841-2845. 10.1039/C8OB00256H.2019
• 37. Wang, X.; Li, M.; Yang, Y.; Guo, M.;* Tang, X.; Wang, G.* One-pot Construction of Difluorinated Pyrrolizidine and Indolizidine Scaffolds via Copper-Catalyzed Radical Cascade Annulation. Adv. Synth. Cat. 2018, 360, 2151-2156. DOI: 10.1002/adsc.201701643.2019
• 36. Li, Y.; Liu, J.; Zhao, S.; Du, X.; Guo, M.;* Zhao, W.; Tang, X.; Wang, G.* Copper-Catalyzed Fluoroolefination of Silyl Enol Ethers and Ke-tones towards the Synthesis of β-Flouroenones. Org. Lett. 2018, 20, 917−920. DOI: 10.1021/acs.orglett.7b03700.2019
• 34. Chen, H.; Wang, X.; Guo, M.; Zhao, W.; Tang, X.;* Wang, G.* Highly Efficient and Versatile Synthesis of α,α-Difluoro-γ-lactams via Aminodifluoroalkylation of Alkenes. Org. Chem. Front. 2017, 4, 2403-2407..2019
• 33. Li, H.; Ren, X.; Zhao, W.;* Tang, X.; Wang, G.* The cross-coupling of directed C-H and organometallic reagents for C-C bond formation. Chin. J. Org. Chem. 2017, 37, 2287-2302..2019
• 32. Wang, X.; Zhao, S.; Liu, J.; Zhu, D.; Guo, M.;* Tang, X.;* Wang, G.* Copper-Catalyzed C−H Difluoroalkylations and Perfluoroalkylations of Alkenes and (Hetero)arenes. Org. Lett. 2017, 19, 4187-4190..2019
• 31. Jing, H.; Feng, X.; Guo, M.; Zhou, S.; Li, Y.; Zhang, J.; Zhao, W.;* Tang, X.; Wang, G.* Copper-catalyzed regioselective formal allylboration of arylsubstituted terminal alkynes with bis(pinacolato)diboron and allyl halides/sulfonates. Asian J. Org. Chem. 2017, 6, 1375-1379..2019
• 30. Zhang, H.; Ren, X.; Zhao, W.;* Tang, X.; Wang, G.* One-pot Synthesis of p-Amino-substituted Unsymmetrical Benzils and Benzil Derivatives. Adv. Synth. Cat. 2017, 359, 395-401..2019
• 29. Wu, J.; Wang, D.; Chen, X.; Gui, Q.; Li, H.; Tan, Z.;* Huang, G.;* Wang, G.* Synthesis of 4-benzylpyridines via Pd-catalyzed CH3-arylation of 4-picoline. Org. Biomol. Chem., 2017, 15, 7509–7512..2019
• 28. Chen, X.; Tan, Z.;* Gui, Q.; Hu, L.; Liu, J.; Wu, J.; Wang, G.* Photocatalytic/Cu-promoted C-H activations: Visible-light-induced ortho-selective perfluoroalkylation of benzamides. Chem. Eur. J. 2016, 22, 6218–6222..2019
• 27. Du, J.; Xu. G.; Lin, H.; Wang, G.;* Tao, M.;* Zhang, W.* Highly efficient reduction of carbonyls, azides, and benzyl halides by NaBH4 in water catalyzed by PANF-immobilized quaternary ammonium salts. Green Chem. 2016, 18, 2726–2735..2019
• 26. Du, J.; Shuai, B.; Tao, M.;* Wang, G.;* Zhang, W.* Pyrrolidine modified PANF catalyst for asymmetric Michael addition of ketones to nitrostyrenes in aqueous phase. Green Chem. 2016, 18, 2625–2631..2019
• 25. Ren, X.; Wang, G.; Tang, X.; Zhao, W.* Iodine-Catalyzed One-Pot Synthesis of α-Ketoamides from Unsaturated Hydrocarbons. Chin. J. Org. Chem. 2015, 35, 1733-1738..2019
• 24. Wang, G.; Xu, S.; Hu, Q.; Zeng, F.; Negishi, E.,* Search for Highly Efficient, Stereoselective, and Practical Synthesis of Complex Organic Compounds of Medicinal Importance as Exemplified by the Synthesis of the C21-C37 Fragment of Amphotericin B, Chem. Eur. J. 2013, 19, 12938-12942..2019
• 23. Xu, S.; Lee, C.-T.; Wang, G.; Negishi, E., * Widely Applicable Synthesis of Enantiomerically Pure Tertiary Alkyl-Containing 1-Alkanols by Zirconium-Catalyzed Asymmetric Carboalumination of Alkenes and Palladium- or Copper-Catalyzed Cross-Coupling, Chem. Asian J. 2013, 8, 1829-1835..2019
• 22. Wang, G.; Mohan, S.; Negishi, E., Highly (≥98%) Selective Synthesis of Conjugated Dienoic and Trienoic Esters of All Possible Configurations Consisting of E and/or Z Disubstituted Alkenes via Alkyne Elementometalation–Pd-Catalyzed Cross-Coupling, Proc. Natl. Acad. Sci. USA, 2011, 108, 11344-11349..2019
• 21. Wang, G.; Yin, N.; Negishi, E., Highly Selective Total Synthesis of Fully Hydroxy-Protected Mycolactones A & B and Their Stereoisomerization upon Deprotection, Chem. Eur. J. 2011, 17, 4118-4130..2019
• 20. Negishi, E.; Wang, G.; Xu, Z., Alkyne Elementometalation–Pd-Catalyzed Cross-Coupling. Towards Synthesis of Any Alkenes in High Yields, Efficiently, Selectively, Economically, and Safely–“Green” Way, J. Org. Chem. 2010, 75, 3151-3182..2019
• 19. Pitsinos, E.; Athinaios, N.; Xu, Z.; Wang, G.; Negishi, E., A Highly Convergent Total Synthesis of (+)-Scyphostatin, Chem. Comm. 2010, 46, 2200-2202..2019
• 15. Wang, G.; Huang, Z.; Negishi, E., Highly stereoselective and Efficient Synthesis of -Heterofunctional Di and Trienoic Esters for Horner-Wadsworth-Emmons Reaction via Alkyne Hydrozirconation and Pd-Catalyzed Alkenylation, Tetrahedron Lett. 2009, 50, 3220-3223..2019
• 14. Wang, G.; Negishi, E., AlCl3-Promoted Facile E-to-Z Isomerization Route to (Z)-2-Methyl-1-buten-1,4-ylidene Synthons for Highly Efficient and Selective (Z)-Isoprenoid Synthesis, Eur. J. Org. Chem. 2009, 1679-1682. .2019
• 13. Wang, G.; Huang, Z.; Negishi, E., Efficient and Selective Syntheses of (all-E)- and (6E, 10Z)-2’-O-Methylmyxalamides D via Pd-Catalyzed Alkenylation–Carbonyl Olefination Synergy, Org. Lett. 2008, 10, 3223-3226..2019
• 12. Negishi, E.; Huang, Z.; Wang, G.; Mohan, S.; Wang, C.; Hattori, H., Recent Advances in Efficient and Selective Synthesis of Di-, Tri-, and Tetrasubstituted Alkenes via Pd-Catalyzed Alkenylation–Carbonyl Olefination Synergy, Acc. Chem. Res. 2008, 41, 1474-1485..2019
• 11. Wang, G.; Zhu, G.; Negishi, E., Zirconium-catalyzed methylalumination of heterosubstituted arylethynes: Factors affecting the regio-, stereo-, and chemoselectivities, J. Organomet. Chem. 2007, 692, 4731-4736. .2019
• 8. Yin, N.; Wang, G.; Qian, M.; Negishi, E., Highly Stereoselective Synthesis of the Side-Chains of Mycolactones A and B Featuring Stepwise Double Substitutions of 1,1-Dibromo-1-alkenes, Angew. Chem. Int. Ed., 2006, 45, 2916-2920..2019
• 7. Negishi, E.; Hu, Q.; Huang, Z.; Qian, M.; Wang, G., Palladium-Catalyzed Alkenylation via Negishi Coupling, Aldrichim. Acta, 2005, 38, 71-88..2019
• 6. Ma, S.; Wang, G., Regioselectivity Control by A Ligand Switch in the Coupling Reaction Involving Allenic/Propargylic Palladium Species, Angew. Chem. Int. Ed. 2003, 42, 4215-4217..2019
• 5. Ma, S.; Wang, G., Unexpected SN2’-Type Addition-Elimination Reactions of 1-Aryl-2, 3-Allenols with LiX. Synthesis and Synthetic Application of 1-Aryl-3-halo-1, 3-dienes, Tetrahedron Lett. 2002, 43, 5723-5726..2019
• 4. Ma, S.; Hou, H.; Zhao, S.; Wang, G., Efficient Synthesis of Optically Active 2, 3-Allenols via the Simple CuBr-Mediated Reaction of Optically Active Propargylic Alcohols with Paraformaldehyde, Synthesis 2002, 1643-1645..2019
• 3. Ma, S.; Xie, H.; Wang, G.; Zhang, J.; Shi, Z., Hydrohalogenation Reaction of Substituted 1, 2-Allenic Carboxylic Acids, Esters, Amides, Nitriles, and Diphenyl Phosphine Oxides, Synthesis 2001, 713-730..2019
• 2. Ma, S.; Li, L.; Wei, Q.; Xie, H.; Wang, G.; Shi, Z.; Zhang, J., Hydrohalogenation Reaction of Electron-Deficient Allenes, Pure & Appl. Chem. 2000, 72, 1739-1743..2019
• 1. Ma, S.; Wang, G., Highly Selective Hydrohalogenation Reaction of Substituted 2, 3-Allenoates, Chin. J. Chem. 1999, 17, 545-549..2019