黄金海，男，博士，博士生导师，天津大学生命科学学院教授。

邮箱: jinhaih@tju.edu.cn, 地址: Building 15, Rm 216, Tianjin University;

中国医药生物技术协会临床前评价技术委员会、中国禽病学会理事，天津市医学微生物与免疫学、畜牧兽医协会常务理事，天津市重大动物疫病控制专家组成员，天津市创新人才推进计划重点领域——动物诊疗智造创新团队负责人。长期从事分子病原学及其免疫学研究，先后主持、参与国家自然基金、国家973、863、天津市自然基金、国家重点研发计划、天津市研究基础及前沿技术重点项目、天津市支撑重点及横向合作项目等30余项。先后获省市级科技进步一、二、三等奖4项，厅局级科技进步一等奖3项，二等奖1项，授权、申报发明专利10余项。已发表论文200余篇，主、参编《分子生物学基本原理及应用实践研究》、《免疫学》等教材及著作9部。

研究方向：免疫生物学；分子病原学与免疫学；微生物合成生物学。

Researcher ID：B-1334-2016, http://www.researcherid.com/rid/B-1334-2016

ORCID: http://orcid.org/0000-0002-1073-533X

研究方向

（1）免疫生物学  新型免疫细胞及其标志分子的挖掘及功能研究；先天性免疫调控分子回路的设计及细胞通路重塑;受体靶向型天然及人工佐剂分子的设计及其调控机制。

（2)微生物合成生物学  益生菌设计、工程化建造、代谢调控机制及健康重塑机制；资源微生物基因组大尺度改造重建技术；基于工程化酵母、噬菌体、乳酸菌的口服黏膜疫苗研发；预测疫苗学及新型疫苗的设计与智造技术；高通量抗体库的工程化构建、高通量筛选及应用开发技术。

（3）病原致病及免疫机理研究  病毒免疫逃逸的先天性免疫机制研究；病毒快速拯救及工程化疫苗研发；病毒致病及抗感染免疫的分子机制。

Selected papers

2024年

l  Ruiqi Sun 1, Yanyu Guo 1, Lilin Zhang 1, Huixia Zhang, Boxuan Yin, Xiaoyang Li, Changyan Li, Liu Yang, Lei Zhang, Zexing Li *, Jinhai Huang *, PRRSV degrades MDA5 via dual autophagy receptors P62 and CCT2 to evade antiviral innate immunity. Virologica Sinica.  2024 Apr;39(2):264-276.

l  Huliang Li †, Deping Hua † , Qingxia Qu, Hongwei Cao, Zhehan Feng, Na Liu, Jinhai Huang*, Lei Zhang * Oral Immunization with Recombinant Saccharomyces cerevisiae Expressing Viral Capsid Protein 2 of Infectious Bursal Disease Virus Induces Unique Specific Antibodies and Protective Immunity. Vaccines, 2023, 11, 1849.

l  Baiping Zhao 1, Yanyu Guo 1, Ruiqi Sun 1, Lilin Zhang , Liu Yang , Xuefeng Mei , Lei Zhang*, Jinhai Huang* , Quadrivalent hemagglutinin and adhesion expressed on Saccharomyces cerevisiae induce protective immunity against Mycoplasma gallisepticum infection and improve gut microbiota. Microbial Pathogenesis 187 (2024) 106511.

 l  Daqing Cui, Shujun Li, Boxuan Yin, Changyan Li, Lilin Zhang, Zexing Li, Jinhai Huang*，Rapid Rescue of Goose Astrovirus Genome via Red/ET Assembly. Food and Environmental Virology.2024, 6,1-10.

2023年

l  Han Zhang, Zexing Li, Huixia Zhang, Yanyu Guo, Xinyi Zhang, Lilin Zhang, Liu Yang, Shujun Li, Changyan Li, Daqing Cui, Ruyu Xie, Yongqing Li， Jinhai Huang*，Recombinant hemagglutinin displaying on yeast reshapes congenital lymphocyte subsets to prompt optimized systemic immune-protection against avian influenza infection. Front. Microbiol. 2023.115392

l  Zhe Sun†, Jinhai Huang† , Zvi Fishelson, Chenhui Wang, Sihe Zhang*, Cell-Penetrating Peptide-Based Delivery of Macromolecular Drugs: Development, Strategies, and Progress. Biomedicines. 2023, 11, 1971.

l  Xiaoyang Li, Ruiqi Sun,  Yanyu Guo,  Huixia Zhang,  Ruyu Xie, Xubin Fu, Lei Zhang, Lilin Zhang, Zexing Li*, Jinhai Huang*, N-Acetyltransferase 9 Inhibits Porcine Reproductive and Respiratory Syndrome Virus Proliferation by N-Terminal Acetylation of the Structural Protein GP5. Microbiology Spectrum, 2023, e02442-22. 

l  Tan Z, Zhai H, Sun R, Sun Z, Xie R, Zhang L, Li Z, Huang J*. Complete genome sequence and phylogenetic analysis of a goose astrovirus isolate in China. Braz J Microbiol. 2023 Mar;54(1):427-434. 

l  Yuanfang Li , Ruiqi Sun , Shujun Li , Zheng Tan , Zexing Li , Yebin Liu,* , Yanyu Guo,* , Jinhai Huang*, ASFV proteins presented at the surface of T7 phages induce strong antibody responses in mice. Journal of Virological Methods, 2023, 316:114725.

l  Ruyu Xie,Huixia Zhang,Han Zhang, Changyan Li,Daqing Cui,Shujun Li, Zexing Li, Hualei Liu*, Jinhai Huang*,  Hemagglutinin expressed by yeast reshapes immune microenvironment and gut microbiota to trigger diverse anti-infection response in infected birds. Frontiers in Immunology, 2023. e1125190

l  Huixia Zhang, Ruyu Xie, Han Zhang, Ruiqi Sun, Shujun Li, Chuandao Xia, Zexing Li, Lilin Zhang,Yanyu Guo*, Jinhai Huang*, Recombinant hemagglutinin protein and DNA-RNA-combined nucleic acid vaccines harbored by yeast elicit protective immunity against H9N2 avian influenza infection. Poultry Science. 2023, 102:102662. 

2022年

l  Ruiqi Sun, Yanyu Guo, Xiaoyang Li, Ruiqiao Li, Jingxuan Shi, Zheng Tan, Lilin Zhang, Lei Zhang,Jun Han*, Jinhai Huang*，PRRSV Non-Structural Proteins Orchestrate Porcine E3 Ubiquitin Ligase RNF122 to Promote PRRSV Proliferation. Viruses 2022, 14, 424.v14020424.

l  Hongwei Cao, Deping Hua, Han Zhang, Huixia Zhang, Na Liu, Zhehan Feng, Huliang Li, Baiping Zhao, Lilin Zhang, Yanyu Guo, Jinhai Huang *, Lei Zhang，Oral immunization of recombinant Saccharomyces cerevisiae expressing fiber-2 of fowl adenovirus serotype 4 induces protective immunity against homologous infection. Veterinary Microbiology 271 (2022) 109490.

l  Lilin Zhang, Lan Yao, Yanyu Guo, Xiaoyang Li, Li Ma, Ruiqi Sun, Xueqing Han, Jing Liu*, Jinhai Huang*, Oral SARS-CoV-2 Spike Protein Recombinant Yeast Candidate Prompts Specific Antibody and Gut Microbiota Reconstruction in Mice. Frontiers in Microbiology |2022, Vol 13. 792532

l  Linjia Su , Zhe Sun ^, Fangzheng Qi ^, Huishan Su ^, Luomeng Qian, Jing Li , Liang Zuo, Jinhai Huang, Zhilin Yu, Jinping Li, Zhinan Chen, Sihe Zhang^*，GRP75-driven, cell-cycle-dependent macropinocytosis of Tat/pDNA-Ca2+ nanoparticles underlies distinct gene therapy effect in ovarian cancer. J Nanobiotechnology. 2022 Jul 20;20(1):340. doi: 10.1186/s12951-022-01530-6.

2021年

l  Yinna Song1#, Yanyu Guo1#, Xiaoyang Li#, Ruiqi Sun, Min Zhu, Jingxuan Shi,Zhen Tan, Lilin Zhang*, Jinhai Huang*， RBM39 alters phosphorylation of c-Jun and binds to viral RNA to promote PRRSV proliferation. Frontiers in Immunology, 2021.12.1-15.

l  Zhe Sun#, Jinhai Huang#, Linjia Su, Jing Li, Fangzheng Qi, Huishan Su, Yanan Chen, Qing Zhang, Qiangzhe Zhang, Zongjin Li, Sihe Zhang, Arf6-mediated macropinocytosis-enhanced suicide gene therapy of C16TAB-condensed Tat/ pDNA nanoparticles in ovarian cancer. Nanoscale, 2021.1-14. 

l  Hui Zhai#, Jingxuan Shi#, Ruiqi Sun, Zheng Tan, Umm E Swaiba, Wanqing Li, Lilin Zhang, Lei Zhang，Yanyu Guo*, Jinhai Huang*，The Superposition Anti-viral Activity of Porcine Tri-subtype Interferon Expressed by Saccharomyces cerevisiae. Veterinary microbiology. 2021

l  Min Zhu#, Xiaoyang Li#, Yinna Song, Peidian Shi, Aiping Cao, Lilin Zhang, yanyu Guo*, Jinhai Huang*, The C/EBPβ-Dependent Induction of TFDP2 Facilitates Porcine Reproductive and Respiratory Syndrome Virus Proliferation. Virologica Sinica, 2021.6,1-11. 

l  Jingxuan Shi #, Heng Chi#, Aiping Cao, Min Zhu, Linlin Zhang, Fuzhou Xu*, Jinhai Huang*，Development of IMBs-qPCR Detection Method for Yersinia enterocolitica Based on the foxA Gene. Archives of Microbiology. 2021, 1-10.

l  Xiaoyang Li#, Yanyu Guo#, Yinna Song#, Ruiqi Sun, Min Zhu, Zheng Tan, Umm E Swaiba, Lilin Zhang, Jinhai Huang*,The Glycosyltransferase ST3GAL2 Modulate the Proliferation and Inflammation Response in PRRSV Infection，Archives of Virology, 2021,1-10.

l  Chen Chen#, Deping Hua#, Jingxuan Shi, Zheng Tan, Min Zhu, Kun Tan, Lilin Zhang, Jinhai Huang*，Porcine immunoglobulin Fc fused P30/P54 protein of African swine fever virus displaying on surface of S. cerevisiae elicit strong antibody production in swine. Virologica Sinica, 2021;36 (2):207-219.

l  Min Zhu, Heng Chi, Xiaoyang Li, Yinna Song, Jingxuan Shi, Jiashun Wang, Jinhai Huang*, The dUTPase of caprine arthritis encephalitis virus negatively regulates interferon signaling pathway, Archives of microbiology, 2021

2020年

l  Aiping Cao, Heng Chi, Jingxuan Shi ,Ruiqi Sun, Kang Du, Yinna Song,Min Zhu, Lilin Zhang, Jinhai Huang* Visual detection of Clostridium perfringens alpha toxin by combining nanometer microspheres with smart phones. Microorganisms 2020,8 (12),1865. 

l  Jiaqi Wu#, HengChi#, Yanyu Guo, Aiping Cao, Jingxuan Shi, Min Zhu, Lilin Zhang, DepingHua*, Jinhai Huang*, Antiviral Protein Viperin Modulate N protein to Inhibit Porcine Epidemic Diarrhea Virus proliferation. Archives of Virology, 2020, 165:2279–2289

l  Peidian Shi, Yanyu Guo, Yanxin Su, Min Zhu, Yali Fu, Heng Chi, Jiaqi Wu, Jinhai Huang*，SUMOylation of DDX39A alters binding & export of antiviral transcripts to control innate immunity. Journal of Immunology, 2020, 205(1):168-180. 

l  Yanyu Guo, Ruiqiao Li, Zheng Tan, Jingxuan Shi, Yali Fu, Yinna Song, Min Zhu, Lei Zhang, Jinhai Huang*，E3 ubiquitin ligase ASB8 negatively regulates interferon via regulating TBK1/IKKi homeostasis. Molecular Immunology. 2020, 121, 195-203. 

l  Yali Fu, Dong Lu,· Yanxin Su,, Heng Chi, Jiashun Wang, Jinhai Huang*，Vif Protein of Caprine Arthritis Encephalitis Virus Inhibits Interferon Production, Archives of Virology. 2020, 1-11.

l  Xiao Xiao,Wentao Zhang, Deping Hua, Lilin Zhang, Wei Meng, Jinhai Huang*, Lei Zhang*, Cold-inducible RNA-binding protein (CIRBP) promotes porcine reproductive and respiratory syndrome virus (PRRSV)-induced inflammatory response. International Immunopharmacology.  2020, 86:106728.

2019年

l  Ruiqiao Li#, Chen Chen#, Jing He, Lilin Zhang, Lei Zhang, Yanyu Guo, Jinhai Huang*, E3 Ligase ASB8 Promotes PRRSV Proliferation and Function via Stabilizing of Nsp 1α and Degrading of IKK. Virology, 2019，532：55–68.

l  Xiao Xiao,Wentao Zhang, Deping Hua, Lilin Zhang, Wei Meng, Jinhai Huang*, Lei Zhang*, Cold-inducible RNA-binding protein (CIRBP) promotes porcine reproductive and respiratory syndrome virus (PRRSV)-induced inflammatory response. International Immunopharmacology. 2020, 86:106728.

l  Chengxue Zhao#, Chen Chen#, Ying Li, Shuren Dong, Kun Tan,,Yuhui Tian,,Lilin Zhang, Jinhai Huang*, Lei Zhang*, Genomic characterization of a novel recombinant porcine astrovirus isolated in northeastern China. Archives of Virology, 2019, 164(3): 1469-1473.

l  Peidian shi#; Yanxin Su#; Yi Li#; Lilin Zhang; Dong Lu; Ruiqiao Li; Lei Zhang; Jinhai Huang*，The alternatively spliced porcine FcγRI regulated PRRSV-ADE infection and proinflammatory cytokine production. Developmental and Comparative Immunology, 2019, 90: 186~196.

l  Peidian Shi1#, Yanxin Su1#, Ruiqiao Li1, Zhixuan Liang, Shuren Dong, Jinhai Huang*，PEDV nsp16 negatively regulates innate immunity to promote viral proliferation. Virus Research, 2019, 265，57–66.

2018年

l  Yanxin Su(#); Peidian Shi(#); Lilin Zhang; Dong Lu; Chengxue Zhao; Ruiqiao Li; Lei Zhang*; Jinhai Huang*,The Superimposed Deubiquitination Effect of OTULIN and PRRSV Nsp11 Promoted the Multiplication of PRRSV. Journal of Virology, 2018.2.12, 92(9): 1-17.

l  Peidian Shi(#); Yanxin Su(#); Ruiqiao Li; Lei Zhang; Chen Chen; Lilin Zhang; Kay Faaberg*; Jinhai Huang*, Dual Regulation of Host TRAIP Post-translation and Nuclear/Plasma Distribution by Porcine Reproductive and Respiratory Syndrome Virus Non-structural Protein 1a Promotes Viral Proliferation. Frontiers in Immunology, 2018.12.6, 9(3023): 1~18.

l  Peidian Shi(#); Lilin Zhang(#); Jiashun Wang(#); Dong Lu; Yi Li; Jie Ren; Menglu Shen; Lei Zhang; Jinhai Huang*, Porcine FceRI Mediates Porcine Reproductive and Respiratory Syndrome Virus Multiplication and Regulates the Inflammatory Reaction. Virologica Sinica (2018) 33:249–260.

l  Chen Pei(#); Zhang Lei(#); Chang Na; Shi Peidian; Gao Tian; Zhang Lilin*, Huang Jinhai*, Preparation of virus-like particles for porcine circovirus type 2 by YeastFab Assembly. Virus Genes, 2018.4, 54(2): 246~255.

l  Lei Zhang#; Jie Ren#; Peidian Shi; Dong Lu; Chengxue Zhao; Yanxin Su; Lilin Zhang; Jinhai Huang*, The Immunological Regulation Roles of Porcine b-1, 4 Galactosyltransferase V (B4GALT5) in PRRSV Infection. Frontiers in Cellular and Infection Microbiology, 2018.2.9, 8(48): 1~13.

l  Ruiqiao Li, Xuefeng Qi,Xueying Han,Caihong Liu, Jing Wang, Ruichun Wang, Jingyu Wang*, Jinhai Huang*,Deterioration of eggshell quality is related to calbindin in laying hens infected with velogenic genotype VIId Newcastle disease virus. Theriogenology.2017,91(3):62-68. IF: 2.288,  Q1, 26/142.

-2017

l  Yi Li, Hui Deng, Pei-Dian Shi, Dan-Dan Xu, Li-Lin Zhang, Lei Zhang*, Jinhai Huang* , Toxic effects of seu are different from those of other staphylococcal enterotoxins. American Journal of Translational Research. 2017, 9(4):1618-1629.

l  Jiashun Wang^#, Yi Li^1#, Hui Deng, Jia Chen, Ying Li, Zhixuan Liang, Deping Hua, Jinhai Huang*. Rapid detection of food-borne Salmonella contamination using IMBs-qPCR method based on pagC gene. Brazilian Journal of Microbiology, 2017.10:3241-9.

l  Menglu Shen, Yi Li, Linlin Zhang, Songbao Dai, Jiashun Wang, Yongqing Li, Lei Zhang*, Jinhai Huang*，Staphylococcal enterotoxin Profile of China Isolates and the Superantigenicity of Some Novel Enterotoxins，Archives of Microbiology.2017, 199: 1-14.

l  Ruiqiao Li,† Lilin Zhang,† Peidian Shi, Hui Deng, Yi Li, Jie Ren, Xubin Fu, Lei Zhang*, Jinhai Huang，Immunological Effects of Different Types of Synthetic CpG Oligodeoxynucleotides on Porcine Cells. RSC advances .2017, 7, 43289-99.

l  Hongzhi Kang, Hui Deng, Menglu Shen, Xianzhi He, Yi Li,Yihe xia, Hongjun Wang, Zhixuan Liang, Jinhai Huang* Superantigenicity analysis of Staphylococcal Enterotoxins SElK and SElQ in a mouse model. RSC advances .2015.5, 29684–29692.

l  Qiangzhe Zhang, Caihong Zhang, Mengxu Gao, Xianzhi He, Yinghua Diao, Sagar M Goyal, Sunil K. Mor, Jinhai Huang*, Evolutionary, epidemiological, demographical, and geographical dissection of porcine bocavirus in China and America. Virus Research. 2015,195 (1): 13–24.

l  Shiwen Zhuang, Junshu Fu, Chris Powell, Jinhai Huang*, Yihe Xia, Ruixiang Yan, Production of medium-chain volatile flavour esters in Pichia pastoris whole-cell biocatalysts with extracellular expression of Saccharomyces cerevisiae acyl-CoA:ethanol O-acyltransferase Eht1 or Eeb1. SpringerPlus, 2015, 4:467-476.

l  Xianzhi He, Lei Zhang, Pengchong Liu, Li Liu, Hu Deng, Jinhai Huang*, Construction and Characterization of VL-VH Tail-parallel Genetically Engineered Antibodies against Staphylococcal Enterotoxins. Immunologic Research.2015,61(3): 281-293.

l  Jianming Wu, Rui Lin, Jinhai Huang, Weihua Guan, William S. Oetting, P. Sriramarao, Malcolm N. Blumenthal, Functional Fcgamma Receptor Polymorphisms Are Associated with Human Allergy. PLOS ONE,2014,Vol 9(2): e89196.

l  Jia Chen, Xianzhi He, Jinhai Huang*, Diet effects in gut microbiome and obesity, Journal of Food Science. 2014，Vol 79（4）: 442–451.

l  Mengmeng Liu, Yi Li,Yihe Xia, Jinhai Huang*,Lili Guo, Detection and genetic analysis of Porcine Bocavirus in different swine herds in North Central China. The world science journal.2014，947084.

l  Jinhai Huang, Sunil K. Mor, Jonathan Erber, Elyce Voss, Sagar M. Goyal, Detection and characterization of porcine bocavirus in United States. Archives of Virology, 2014,159 (7):1797-1801.

l  Jinhai Huang, Yi Li, Mengmeng Liu, Yihe Xia, Zhirong Li, A Novel Subgenotype of Torque teno Virus 1 (TTSuV1) in Slaughter Pigs in China. Food and environmental virology. 2013,226-230.

l  Xu Cong,Junfeng Jiang,Tiegen Liu, Kun Liu,Pengchong Liu,Jinhai Huang,Qiang Ji,Yimo Zhang, Characterization of immobileization of staphylococcal enterotoxin an antibody on microtube. Sensor Letters, 2012, Vol 10:1523-1527.

l  Yi Li, Fengjuan Zhou, Xia Li, Jianhua Wang, Xiangping Zhao,Jinhai Huang*， Development of TaqMan-based qPCR method for detection of caprine arthritis-encephalitis virus (CAEV) infection. Archives of Virology, 2013，158:2135-2141.

l  Jin-Hai Huang,Yue-Hui Sun,Yebing Liu,Huazhi Xiao,Shiwen Zhuang，Development of a loop-mediated isothermal amplification method for rapid detection of Caprine arthritis encephalitis virus proviral DNA. Archives of Virology, 2012. 157（8）:1463-1469.

l  Jianming Wu, Maureen Richards; Jinhai Huang; Lena Al-Harthi; Xiulong Xu; Rui Lin; Fenglong Xie; Andrew W. Gibson; Jeffrey C. Edberg; Robert P. Kimberly. Human, FasL Gene is a Target of β-catenin/T-cell Factor Pathway and Complex FasL Haplotypes Alter Promoter Functions". PLoS ONE, 2011，Vol 6（10）：e26143.

l  Han Xueqing，Lin Xiangmei，Liu Bohua，Hou Yihong,Huang Jinhai，et al，Simultaneously subtyping of all influenza A viruses using DNA microarrays，Journal of Virological Methods，2008，152(1-2)：117–121.

Authorized Patents

·          China/ZL201110049950.X: The real-time PCR method to differentiating classic and high virulent strains of porcine reproductive and respiratory syndrome virus.

·          China/ZL200710064255.4: Gene chips for detection and genotyping of avian influenza viruses.

·          China/ ZL2006100894635: aGST-ELISA method to detect avian influenza virus antibodies. 

·          China/ ZL200620027159.3: A new lamb incubator.

·          China/ ZL200620027282.5: A sponge pessary implant device used for goats.

·          China/ ZL200620027751.3: A device with light for dairy vagina detection.

·          China/ ZL200620027281.0: A calf raising bed.

Selected Published Books 

·          Huang Jinhai (chief editor), Principles of Molecular Biology & Practical Application. China Atomic Press.2015.12

·          Changxin Wu, et.al., 10000 Selected Problems in Sciences—Agriculture Ssciences. China Science Press.2011.

·          Wang Jiaxin, Qin Aijian, Huang Jinhai, et. al., Immunology, China Agriculture Press.2009.

·          Diao Enjie, Xu Baocheng, Huang Jinhai. et. al., Food Safety and Quality Management. Chemistry Industry Press.2008.

·          Li Zhirong, Ding Shuangyang, Huang Jinhai. et. al., Detection Techniques of Veterinary Drug Residues. Tianjin Science and Technology Press.2008.

·          Shi Zhicheng, Wang Jianhua, Huang Jinhai. et. al., Animal Toxiology, China Agriculture Press.2002.

Research Projects

·          “Biosythesis of Key proteins used in veterinary medicine”(TSBICIP-KJGG-014)，supported by Synthetic biotechnology innovation capability improvement project.

·          R&D of multi-valent avian influenza vaccine based on Saccharomyces cerevisiae chassis”(20YFZCSN00340)., supported by underprop project of Tianjin Science and Technology committee in Tianjin,China.

·          “Molecular mechanism of multisystem inflammation syndrome caused by staphylococcal enterotoxins”，supported by National Science Fund in China (31272540）

·          “Study on the virus-like particle vaccine of porcine circovirus type 2 using self-designed S. cerevisiae system”, supported by underprop project of Tianjin Science and Technology committee in Tianjin (16YFZCNC00640)

·          “ Techniques of cell suspension culture in animal vaccine preparation”, Tianjin science and technology support key project plan(13ZCZDNC08800)

·          “ Immobiltzation of Recombinant Chitinase with Magnetic Carrier and Analysis on Structure and Effect”(31101362)，supported by National Science Fund in China

·          “Development of genotyping method and high-output detection kits of staphylococcal enterotoxins in food”(08JCZDJC22600) , supported by a grant from the application basement & advanced technology project of Tianjin Science and Technology committee in Tianjin ,China.

·          “R&D of a recombinant of porcine antimicrobial Peptide”(07ZCKFNC00600)., supported by underprop project of Tianjin Science and Technology committee in Tianjin,China.

·          “Study on pathogen variation and control measure of procine productive and respiratory syndrome in Tianjin region ” (08JCZDJC22900), supported by a grant from the application basement & advanced technology project of Tianjin Science and Technology committee in Tianjin ,China.

·          “Molecular mechanisms of immune response of goats infected with caprine arthritis encephalitis virus”，supported by national Science fund (30771613) in China.

·          “Research on the protein-chip for diagnosis of some important bovine infectious diseases”, 06YFGZSH02100, supported by Tianjin Administration of Quality Supervision, Inspection and Quarantine of the People's Republic of China.

·          “Study on of the molecular diagnosis kits for diagnosis of caprine arthritis encephalitis virus ”supported by General Administration of Quality Supervision, Inspection and Quarantine of the People's Republic of China.

·          “Construction of recombinant plasmid of chicken Marek's disease virus and preparation of major protective antigen protein”, 2013GKF-0482, Beijing academy of agriculture science.

·          “Rapid detection of Foot and mouth disease virus, avian influenza virus by Helicase-dependent Isothermal DNA Amplification(HAD) techniques”, 2009IK021,Beijing Administration of Quality Supervision, inspection and Quarantine of the People's Republic of China.

·          “Diagnosis & control key techniques of animal epidemic diseases”, a collaboration plan of foreign expert, supported by Tianjin government.

Reviewer for

PLOS pathogens; Frontiers in Immunology; Journal of Virology；Journal of Agriculture and Food Chemistry; Veterinary Microbiology; Virologica Sinica; Frontiers in Microbiology; Archives of Virology; Journal of virological methods; BMC Complementary and Alternative Medicine; Journal of Veterinary Science & Technology; Journal of food safety