研究领域为药物传递系统的构建及应用，在脂质代谢相关疾病、心血管疾病、慢性炎症及恶性肿瘤治疗方向开展过多方面探索性研究。先后入选“全球前10万顶尖科学家”，王宽诚教育基金资助青年学者，天津市“青年人才托举工程”，天津市创新人才推进计划青年科技优秀人才，天津大学“北洋学者青年骨干教师”计划。主持或作为骨干成员参与国家自然科学基金项目、军委科技委重大专项、天津市军民融合重大专项、中英合作项目、天津市自然基金项目等多项科研项目，累计经费300余万；近年来，以唯一或最后通讯作者发表SCI论文60余篇，影响因子超过300，他引共计1800余次，h-index为26，其中40余篇一区文章（影响因子>10文章13篇，ESI高被引论文1篇），包括Adv Func Mater, Biomaterials, Acta Pharm Sin B, Theranostics, J Control Release, Nano Research, Chem Eng J等。参编英文论著7部，获得国家授权专利4项。

• Study on various nanocarrier systems in cancer therapy.
• 1. Physiotherapy and chemotherapy are employed synergistically to amplify anti-tumor function.
  Combination therapies are commonly employed synergistically to
  treat high-risk tumors with a goal of total tumor eradication.
• 2. Multi-functionalized nanocarriers facilitate tumor targeting therapy.
  Nanocarriers were functionalized by various ways to perform efficient tumor targeting and controlled release.
• 3. Smart-responsive liposomal system for tumor-specific therapeutics.
  Smart liposomal system could receive specific signals broadcasted from tumor cells, thus realize specifically triggered-release.

• 全球前十万顶尖科学家
• 天津市青年托举工程人才
• Young Talent of 2015, School of Pharmaceutical Science and Technology, 2016
• KC Wong's Postdoc Fellowship, King's College London, 2015.

• Tan XX, Wang JP, Pang XJ, Liu L, Sun Q, You Q, Tan FP**, and Li N*. Indocyanine green-loaded silver nanoparticle@Polyaniline core/shell theranostic nanocomposites for photoacoustic/near-infrared fluorescence imaging-guided and single-light triggered photothermal and photodynamic therapy, ACS Appl. Mater. Interfaces, 8 (51): 34991-35003, 2016.
• Pang XJ, Wang JP, Tan XX, Guo F, Lei MZ, Ma M, Yu M, Tan FP, Li N*. Dual-modal imaging-guided theranostic nanocarriers based on indocyanine green and mTOR inhibitor rapamycin, ACS Applied Materials & Interfaces, 8 (22): 13819–13829, 2016.
• Wang JP, Tan XX, Pang XJ, Liu L, Tan FP*, and Li N*. MoS2 quantum dot@Polyaniline inorganic−organic nanohybrids for in vivo dual-modal imaging guided synergistic photothermal/radiation therapy. ACS Applied Materials & Interfaces, 8 (37): 24331–24338, 2016.
• Wang JP, Guo F, Yu M, Liu L, Tan FP, Yan R*, Li N*. Rapamycin/DiR loaded lipid-polyaniline nanoparticles for dual-modal imaging guided enhanced photothermal and antiangiogenic combination therapy. Journal of controlled release, 237: 23-34, 2016.
• Yu M, Guo F, Wang JP, Tan FP, Li N*. A pH-driven and photoresponsive nanocarrier: remotely-controlled by near-Infrared light for stepwise antitumor treatment, Biomaterials, 79: 25-35, 2016.
• Li N, Yu ZL, Pham TT, Blower PJ, and Yan R*, A generic 89Zr labeling method to quantify the in vivo pharmacokinetics of liposomal nanoparticles with positron emission tomography, International journal of nanomedicine, 12: 3281-3294, 2017.
• Pang XJ, Tan XX, Wang JP, Liu L, You Q, Sun Q, Wang YD, Tan FP, Li N*. Hollow Au-Cu nanocomposite for real-time tracing photothermal/anti-angiogenic therapy, Advanced Healthcare Materials, 6 (13): 1-12, 2017.
• Liu L, Wang JP, Tan XX, Pang XJ, You Q, Sun Q, Tan FP, Li N*. Photosensitizer loaded MoS2-Au hybrid for CT/ NIRF imaging-guided stepwise photothermal and photodynamic therapy. Journal of Materials Chemistry B, 5: 2286-2296, 2017.
• You Q, Sun Q, Yu M, Wang JP, Liu L, Wang YD, Cheng Y, Song YL, Wang SY, Tan FP, Li N*. BSA-bioinspired gadolinium hybrids functionalized hollow gold nanoshells for NIRF/PA/CT/MR quad-modal diagnostic imaging guided photothermal/photodynamic cancer therapy, ACS Applied Materials & Interfaces, 9 (46), 40017–40030, 2017.
• Wang JP, Pang XJ, Tan XX, Liu L, You Q, Sun Q, Tan FP, Li N*. A triple-synergistic strategy for combinational photo/radiotherapy and multi-modality imaging based on hyaluronic acid-hybridized polyaniline-coated WS2 nanodots, Nanoscale, 9: 5551-5564, 2017.
• You Q, Sun Q, Wang JP, Tan XX, Pang XJ, Liu L, Yu M, Tan FP, Li N*. A single-light triggered and dual-imaging guided multifunctional platform for combined photothermal and photodynamic therapy based on TD-controlled and ICG-loaded CuS@mSiO2, Nanoscale, 9: 3784–3796, 2017. (Front cover)
• Sun Q, You Q, Pang XJ, Tan XX, Wang JP, Liu L, Guo F, Tan FP**, Li N*. A photoresponsive and rod-shape nanocarrier: Single wavelength of light triggered photothermal and photodynamic therapy based on AuNRs-capped & Ce6-doped mesoporous silica nanorods, Biomaterials, 122:188-200, 2017.
• Wang JP, Li N*. Functional hollow nanostructures for imaging and phototherapy of tumor, Journal of Materials Chemistry B, 5: 8430-8445, 2017. (review article)
• Wang SY#, Guo F#, Ji YH, Yu M, Wang JP, Li N*. Dual-mode imaging guided multifunctional theranosomes with mitochondria targeting for photothermally controlled and enhanced photodynamic therapy in vitro and in vivo, Molecular Pharmaceutics, 15, 8: 3318-3331, 2018.
• Song YL, Wang JP, Liu L, Sun Q, You Q, Cheng Y, Wang YD, Wang SY, Tan FP, Li N*. One-Pot Synthesis of a Bismuth Selenide Hexagon Nanodish Complex for Multimodal Imaging-Guided Combined Antitumor Phototherapy, Molecular Pharmaceutics, 15, 5: 1941-1953, 2018.
• Liu L, Wang JP, Sun Q, You Q, Pang XJ, Tan XX, Song YL, Wang YD, Cheng Y, Tan FP and Li N*, NIRF/PA/CT multi-modality imaging guided combined photothermal and photodynamic therapy based on tumor microenvironment-responsive nanocomposites, Journal of Materials Chemistry B, 6: 4239-4250, 2018.
• Wang YD, Pang XJ, Wang JP, Cheng Y, Song YL, Sun Q, You Q, Liu L, Wang SY, Tan FP, Li J*, Li N*. Magnetically-targeted and near infrared fluorescence/magnetic resonance/photoacoustic imaging-guided combinational anti-tumor phototherapy based on polydopamine-capped magnetic prussian blue nanoparticles, Journal of Materials Chemistry B, 6: 2460-2473, 2018.
• Sun Q, You Q, Wang JP, Liu L, Wang YD, Song YL, Cheng Y, Wang SY, Tan FP, Li N*. Theranostic nanoplatform: Triple-model imaging guided synergistic cancer therapy based on liposomes conjugated mesoporous silica nanoparticles, ACS Applied Materials & Interfaces, 10 (2): 1963-1975, 2018.
• Cheng Y, Tan XX, Wang JP, Wang YD, Song YL, You Q, Sun Q, Liu L, Wang SY, Tan FP, Li J*, Li N*. Polymer-based gadolinium oxide nanocomposites for FL/MR/PA imaging guided and Photothermal/photodynamic combined anti-tumor therapy, Journal of Controlled Release, 277, 77-88, 2018.
• Wang JP, Liu L, You Q, Song YL, Sun Q, Wang YD, Cheng Y, Tan FP, Li N*. All-in-one theranostic nanoplatform based on hollow MoSx for photothermally maneuvered oxygen self-enriched photodynamic therapy, Theranostics, 8 (4): 955-971, 2018.
• Cheng Y#, Lu T#, Wang YD, Wang JP, Song YL, You Q, Sun Q, Liu L, Wang SY, Tan FP, Li J*, Li N*. GSH-mediated Clearable Nanoparticles Based on Ultra-small Gd2O3 for Multi-Modal Imaging-guided Photothermal/Radio Combined Antitumor Therapy. Molecular Pharmaceutics, 16 (8): 3489-3501, 2019.
• Lu QL, Sun Q, Li PS, Yang LF, Yang S, Wang YD, Cheng Y, Song YL, Wang SY, Tan FP* and Li N*. Photothermal-activatable PDA immune nanomedicine combine with PD-L1 checkpoint blockade for anti-metastatic cancer photoimmunotherapy, Journal of Materials Chemistry B, 7: 2499-2511, 2019.
• Song YL, Wang YL, Zhu Y, Cheng Y, Wang YD, Wang SY, Tan FP, Lian F,* Li N*, Biomodal Tumor-targeted and Redox-responsive Bi2Se3 Hollow Nanocubes for MSOT/CT Imaging Guided Synergistic Low-Temperature Photothermal-Radiotherapy, Advanced Healthcare Materials, 8 (16): 1900250, 2019.
• Li PS, Liu L, Lu QL, Yang S, Yang LF, Cheng Y, Wang YD, Wang SY, Song YL, Tan FP*, and Li N*. Ultrasmall MoS2 nanodots doped biodegradable SiO2 nanoparticles for clearable FL/CT/MSOT imaging guided PTT/PDT combination tumor therapy. ACS Applied Materials & Interfaces, 11 (6): 5771–5781, 2019.
• Yang S, You Q, Yang LF, Li PS, Lu QL, Wang SY, Tan FP, Ji YH*, Li N. Rod-like MSN@Au nanohybrids modified supermolecular photosensitizer for NIRF/MSOT/CT/MR quadmodal imaging guided photothermal/photodynamic cancer therapy. ACS Applied Materials & Interfaces, 11 (7): 6777-6788, 2019.
• Wang SY, You Q, Wang JP, Song YL, Cheng Y, Wang YD, Yang S, Yang LF, Li PS, Lu QL, Yu M*, Li N*. MSOT/CT/MR imaging guided and hypoxia maneuvered oxygen self-sufficiency radiotherapy based on one-pot MnO2-mSiO2 @ Au nanoparticle. Nanoscale, 11: 6270-6284, 2019.
• Yang LF, Wang JP, Yang S, Lu QL, Li PS, Li N*. Rod-shape MSN@MoS2 nanoplatform for FL/MSOT/CT imaging-guided photothermal and photodynamic therapy. Theranostics, 9 (14), 3992-4005, 2019. (Front cover)
• Song YL, Wang YD, Wang SY, Cheng Y, Lu QL, Tan FP, Li N*. Immune-adjuvant loaded Bi2Se3 nanocage for photothermal-improved PD-L1 checkpoint blockade immune-tumor metastasis therapy. Nano Research, 12 (8): 1770-1780, 2019. (Front cover)
• Wang YD, Song SZ, Lu T, Cheng Y, Song YL, Wang SY, Tan FP, Wang YL, Zhu Y, Li J*, Li N*. Oxygen-supplementing mesoporous polydopamine nanosponge with WS2 QDs-embedded for CT/MSOT/MR imaging and thermoradiotherapy of hypoxic cancer. Biomaterials, 220: 119405, 2019.
• Ren CC, Cheng Y, Li W, Liu P, Yang LF, Lu QL, Xu M, Tan FP, Li J*, Li N*. Ultra-small Bi2S3 nanodots-doped reversible Fe (Ⅱ/Ⅲ)-based hollow mesoporous prussian blue nanocubes for amplified tumor oxidative stress augmented photo-/radiotherapy, Biomaterials Science, 8, 1981-1995, 2020.
• Yang LF, Lu QL, Ren CC, Xu M, Song YL, Liu P, Li W, Wang XX*, Li N*. Rod-shape inorganic biomimetic mutual-reinforcing MnO2-Au nanozymes for catalysis-enhanced hypoxic tumor therapy, Nano Research, 13 (8): 2246-2258, 2020.
• Xu M, Lu QL, Song YL, Yang LF, Ren CC, Li W, Liu P, Wang YL, Zhu Y, Li N*. NIR-II driven plasmon-enhanced cascade reaction for tumor microenvironment-regulated catalytic therapy based on bio-breakable Au-Ag nanozyme, Nano Research, 13 (8): 2118-2129, 2020.
• Liu P, Wang YD, Liu Y, Tan FP, Li JN*, Li N*. S-Nitrosothiols loaded mini-sized Au@silica nanorod for collagen depletion and mitochondrial damage in solid tumor treatment, Theranostics, 10 (15): 6774-6789, 2020.
• Li W, Wang SY, Ren CC, Liu P, Lu QL, Yang LF, Song YL, Xu M, Tan FP, Yu M*, Li N*. Exo/Endogenous dual-augmented chemodynamic therapy based on bio-reducible and bio-breakable copper (Ⅱ)-based truncated octahedron, Chemical Engineering Journal, 396: 125280, 2020.
• Xu M, Lu QL, Song YL, Yang LF, Li JN*, Li N*. Enhanced Bax upregulating in mitochondria for deep tumor therapy based on SO2 prodrug loaded Au–Ag hollow nanotriangles, Biomaterials, 250: 120076, 2020.
• Song YL, Yang LF, Xu M, Lu QL, Li W, Ren CC, Liu P, Wang YL, Zhu Y, Tan FP, Li N*. Boosted photocatalytic activity induced NAMPT-regulating therapy based on elemental bismuth-humic acids heterojunction for inhibiting tumor proliferation/migration/inflammation, Biomaterials, 254: 120140, 2020.
• Lu QL, Lu T, Xu M, Yang LF, Song YL, Li N*, SO2 prodrug doped nanorattles with extra-high drug payload for “collusion inside and outside” photothermal/pH triggered - gas therapy, Biomaterials, 257: 120236, 2020.
• Xu M#, Song YL#, Wang JP**, Li N*. Anisotropic transition metal–based nanomaterials for biomedical applications, View, 2:20200154, 2021.
• Song YL#, Jing HQ#, Vong LB, Wang JP**, Li N*. Recent advances in targeted stimuli-responsive nano-based drug delivery systems combating atherosclerosis, Chinese Chemical Letters, doi.org/10.1016/j.cclet.2021.10.055, 2021.
• Li W, Song YL, Liang XY, Zhou Y, Xu M, Lu Q, Wang XX**, and Li N*. Mutual-reinforcing sonodynamic therapy against rheumatoid arthritis based on sparfloxacin sonosensitizer doped concave-cubic rhodium nanozyme, Biomaterials, 276: 121063, 2021.
• Xu M, Zhou Y, Ren CC, Liang XY, Li N*. Palladium hydride nanopocket cubes and their H2-therapy function in amplifying inhibition of foam cells to attenuate atherosclerosis, Advanced Functional Materials, 2104892, 2021.
• Lu Q, Zhou Y, Xu M, Liang XY, Jing HQ, Wang XX*, Li N*. Sequential delivery for hepatic fibrosis treatment based on carvedilol loaded star-like nanozyme, Journal of Controlled Release, 341:247-260, 2022.
• Song YL, Li W, Jing HQ, Liang XY, Zhou Y, Li N*, Feng SQ*.Spatiotemporal sonodynamic therapy for the treatment of rheumatoid arthritis based on Z-scheme heterostructure sonosensitizer of HO-1 inhibitor jointed bismuth nanotriangle. Chemical Engineering Journal, 438:135558, 2022.
• Wang SY, Zhou Y, Liang XY, Xu M, Li N*, Zhao K*. Platinum-Cerium bimetallic nano-raspberry for atherosclerosis treatment via synergistic foam cell inhibition and P2Y12 targeted antiplatelet aggregation, Chemical Engineering Journal, 430: 132859, 2022.