LiNan
School
School of Pharmaceutical Science and Technology
Professional Title
Associate professor
Administrative Appointments
Lecturer
Discipline
Pharmaceutics
Contact Information
022-27404986
linan1985@tju.edu.cn
Room A501, Building 24, Tianjin University
Brief Introduction
Nan Li received her Ph.D. degree from Tianjin University in 2012, and after that she joined the School of Pharmaceutical Science and Technology of Tianjin University. Now she is an associate professor major in pharmaceutics. From 2016 to 2017, she was a postdoctoral fellow at King's College London. Her research interests mainly focus on the various functional nanomaterials and nanotechnologies for tumor, cardiovascular disease as well as chronic inflammation treatment. Nan Li has published more than 60 SCI papers, including Advanced Functional Materials, Biomaterials, Theranostics, Journal of Controlled Release and so on. The citation times are more than 1800 with H-index of 26.
Education Background
- Doctoral degree| Tianjin University| School of Pharmaceutical Science and Technology| 2012
- Bachelor’s Degree| Tianjin University| School of Pharmaceutical Science and Technology| 2007
Research Interests
- Study on various nanocarrier systems in cancer therapy.
- 3. Physiotherapy and chemotherapy are employed synergistically to amplify anti-tumor function.
Combination therapies are commonly employed synergistically to
treat high-risk tumors with a goal of total tumor eradication. - 2. Multi-functionalized nanocarriers facilitate tumor targeting therapy.
Nanocarriers were functionalized by various ways to perform efficient tumor targeting and controlled release. - 1. Smart-responsive liposomal system for tumor-specific therapeutics.
Smart liposomal system could receive specific signals broadcasted from tumor cells, thus realize specifically triggered-release.
Professional Membership
- Committee member of Tianjin Physicians association orthopaedic branch innovation and transformation work committee
- Committee member of Biological particles professional committee of Chinese Society of Particuology
- Committee member of Chinese society of biomedical engineering Nanomedicine and engineering branch committee
- Youth editorial board member of Chinese Chemical Letters
- Youth editorial board member of Asian journal of pharmaceutical sciences
Positions & Employments
-
2017.7-2022.3
School of pharmaceutical science and technology | Tianjin University | Secretary of Youth League Committee | Associate Professor -
2016.9-2017.6
King's College London | Postdoc -
2012.9-2017.6
School of pharmaceutical science and technology | Tianjin University | Lecturer
Academic Achievements
- Papers
- [1] Tan XX, Wang JP, Pang XJ, Liu L, Sun Q, You Q, Tan FP**, and Li N*. Indocyanine green-loaded silver nanoparticle@Polyaniline core/shell theranostic nanocomposites for photoacoustic/near-infrared fluorescence imaging-guided and single-light triggered photothermal and photodynamic therapy, ACS Appl. Mater. Interfaces, 8 (51): 34991-35003, 2016.
- [2] Pang XJ, Wang JP, Tan XX, Guo F, Lei MZ, Ma M, Yu M, Tan FP, Li N*. Dual-modal imaging-guided theranostic nanocarriers based on indocyanine green and mTOR inhibitor rapamycin, ACS Applied Materials & Interfaces, 8 (22): 13819–13829, 2016.
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- [3] Wang JP, Tan XX, Pang XJ, Liu L, Tan FP*, and Li N*. MoS2 quantum dot@Polyaniline inorganic−organic nanohybrids for in vivo dual-modal imaging guided synergistic photothermal/radiation therapy. ACS Applied Materials & Interfaces, 8 (37): 24331–24338, 2016.
- [4] Wang JP, Guo F, Yu M, Liu L, Tan FP, Yan R*, Li N*. Rapamycin/DiR loaded lipid-polyaniline nanoparticles for dual-modal imaging guided enhanced photothermal and antiangiogenic combination therapy. Journal of controlled release, 237: 23-34, 2016.
- [5] Yu M, Guo F, Wang JP, Tan FP, Li N*. A pH-driven and photoresponsive nanocarrier: remotely-controlled by near-Infrared light for stepwise antitumor treatment, Biomaterials, 79: 25-35, 2016.
- [6] Li N, Yu ZL, Pham TT, Blower PJ, and Yan R*, A generic 89Zr labeling method to quantify the in vivo pharmacokinetics of liposomal nanoparticles with positron emission tomography, International journal of nanomedicine, 12: 3281-3294, 2017.
- [7] Pang XJ, Tan XX, Wang JP, Liu L, You Q, Sun Q, Wang YD, Tan FP, Li N*. Hollow Au-Cu nanocomposite for real-time tracing photothermal/anti-angiogenic therapy, Advanced Healthcare Materials, 6 (13): 1-12, 2017.
- [8] Liu L, Wang JP, Tan XX, Pang XJ, You Q, Sun Q, Tan FP, Li N*. Photosensitizer loaded MoS2-Au hybrid for CT/ NIRF imaging-guided stepwise photothermal and photodynamic therapy. Journal of Materials Chemistry B, 5: 2286-2296, 2017.
- [9] You Q, Sun Q, Yu M, Wang JP, Liu L, Wang YD, Cheng Y, Song YL, Wang SY, Tan FP, Li N*. BSA-bioinspired gadolinium hybrids functionalized hollow gold nanoshells for NIRF/PA/CT/MR quad-modal diagnostic imaging guided photothermal/photodynamic cancer therapy, ACS Applied Materials & Interfaces, 9 (46), 40017–40030, 2017.
- [10] Wang JP, Pang XJ, Tan XX, Liu L, You Q, Sun Q, Tan FP, Li N*. A triple-synergistic strategy for combinational photo/radiotherapy and multi-modality imaging based on hyaluronic acid-hybridized polyaniline-coated WS2 nanodots, Nanoscale, 9: 5551-5564, 2017.
- [11] You Q, Sun Q, Wang JP, Tan XX, Pang XJ, Liu L, Yu M, Tan FP, Li N*. A single-light triggered and dual-imaging guided multifunctional platform for combined photothermal and photodynamic therapy based on TD-controlled and ICG-loaded CuS@mSiO2, Nanoscale, 9: 3784–3796, 2017. (Front cover)
- [12] Sun Q, You Q, Pang XJ, Tan XX, Wang JP, Liu L, Guo F, Tan FP**, Li N*. A photoresponsive and rod-shape nanocarrier: Single wavelength of light triggered photothermal and photodynamic therapy based on AuNRs-capped & Ce6-doped mesoporous silica nanorods, Biomaterials, 122:188-200, 2017.
- [13] Wang JP, Li N*. Functional hollow nanostructures for imaging and phototherapy of tumor, Journal of Materials Chemistry B, 5: 8430-8445, 2017. (review article)
- [14] Wang SY#, Guo F#, Ji YH, Yu M, Wang JP, Li N*. Dual-mode imaging guided multifunctional theranosomes with mitochondria targeting for photothermally controlled and enhanced photodynamic therapy in vitro and in vivo, Molecular Pharmaceutics, 15, 8: 3318-3331, 2018.
- [15] Song YL, Wang JP, Liu L, Sun Q, You Q, Cheng Y, Wang YD, Wang SY, Tan FP, Li N*. One-Pot Synthesis of a Bismuth Selenide Hexagon Nanodish Complex for Multimodal Imaging-Guided Combined Antitumor Phototherapy, Molecular Pharmaceutics, 15, 5: 1941-1953, 2018.
- [16] Liu L, Wang JP, Sun Q, You Q, Pang XJ, Tan XX, Song YL, Wang YD, Cheng Y, Tan FP and Li N*, NIRF/PA/CT multi-modality imaging guided combined photothermal and photodynamic therapy based on tumor microenvironment-responsive nanocomposites, Journal of Materials Chemistry B, 6: 4239-4250, 2018.
- [17] Wang YD, Pang XJ, Wang JP, Cheng Y, Song YL, Sun Q, You Q, Liu L, Wang SY, Tan FP, Li J*, Li N*. Magnetically-targeted and near infrared fluorescence/magnetic resonance/photoacoustic imaging-guided combinational anti-tumor phototherapy based on polydopamine-capped magnetic prussian blue nanoparticles, Journal of Materials Chemistry B, 6: 2460-2473, 2018.
- [18] Sun Q, You Q, Wang JP, Liu L, Wang YD, Song YL, Cheng Y, Wang SY, Tan FP, Li N*. Theranostic nanoplatform: Triple-model imaging guided synergistic cancer therapy based on liposomes conjugated mesoporous silica nanoparticles, ACS Applied Materials & Interfaces, 10 (2): 1963-1975, 2018.
- [19] Cheng Y, Tan XX, Wang JP, Wang YD, Song YL, You Q, Sun Q, Liu L, Wang SY, Tan FP, Li J*, Li N*. Polymer-based gadolinium oxide nanocomposites for FL/MR/PA imaging guided and Photothermal/photodynamic combined anti-tumor therapy, Journal of Controlled Release, 277, 77-88, 2018.
- [20] Wang JP, Liu L, You Q, Song YL, Sun Q, Wang YD, Cheng Y, Tan FP, Li N*. All-in-one theranostic nanoplatform based on hollow MoSx for photothermally maneuvered oxygen self-enriched photodynamic therapy, Theranostics, 8 (4): 955-971, 2018.
- [21] Cheng Y#, Lu T#, Wang YD, Wang JP, Song YL, You Q, Sun Q, Liu L, Wang SY, Tan FP, Li J*, Li N*. GSH-mediated Clearable Nanoparticles Based on Ultra-small Gd2O3 for Multi-Modal Imaging-guided Photothermal/Radio Combined Antitumor Therapy. Molecular Pharmaceutics, 16 (8): 3489-3501, 2019.
- [22] Lu QL, Sun Q, Li PS, Yang LF, Yang S, Wang YD, Cheng Y, Song YL, Wang SY, Tan FP* and Li N*. Photothermal-activatable PDA immune nanomedicine combine with PD-L1 checkpoint blockade for anti-metastatic cancer photoimmunotherapy, Journal of Materials Chemistry B, 7: 2499-2511, 2019.
- [23] Song YL, Wang YL, Zhu Y, Cheng Y, Wang YD, Wang SY, Tan FP, Lian F,* Li N*, Biomodal Tumor-targeted and Redox-responsive Bi2Se3 Hollow Nanocubes for MSOT/CT Imaging Guided Synergistic Low-Temperature Photothermal-Radiotherapy, Advanced Healthcare Materials, 8 (16): 1900250, 2019.
- [24] Li PS, Liu L, Lu QL, Yang S, Yang LF, Cheng Y, Wang YD, Wang SY, Song YL, Tan FP*, and Li N*. Ultrasmall MoS2 nanodots doped biodegradable SiO2 nanoparticles for clearable FL/CT/MSOT imaging guided PTT/PDT combination tumor therapy. ACS Applied Materials & Interfaces, 11 (6): 5771–5781, 2019.
- [25] Yang S, You Q, Yang LF, Li PS, Lu QL, Wang SY, Tan FP, Ji YH*, Li N. Rod-like MSN@Au nanohybrids modified supermolecular photosensitizer for NIRF/MSOT/CT/MR quadmodal imaging guided photothermal/photodynamic cancer therapy. ACS Applied Materials & Interfaces, 11 (7): 6777-6788, 2019.
- [26] Wang SY, You Q, Wang JP, Song YL, Cheng Y, Wang YD, Yang S, Yang LF, Li PS, Lu QL, Yu M*, Li N*. MSOT/CT/MR imaging guided and hypoxia maneuvered oxygen self-sufficiency radiotherapy based on one-pot MnO2-mSiO2 @ Au nanoparticle. Nanoscale, 11: 6270-6284, 2019.
- [27] Yang LF, Wang JP, Yang S, Lu QL, Li PS, Li N*. Rod-shape MSN@MoS2 nanoplatform for FL/MSOT/CT imaging-guided photothermal and photodynamic therapy. Theranostics, 9 (14), 3992-4005, 2019. (Front cover)
- [28] Song YL, Wang YD, Wang SY, Cheng Y, Lu QL, Tan FP, Li N*. Immune-adjuvant loaded Bi2Se3 nanocage for photothermal-improved PD-L1 checkpoint blockade immune-tumor metastasis therapy. Nano Research, 12 (8): 1770-1780, 2019. (Front cover)
- [29] Wang YD, Song SZ, Lu T, Cheng Y, Song YL, Wang SY, Tan FP, Wang YL, Zhu Y, Li J*, Li N*. Oxygen-supplementing mesoporous polydopamine nanosponge with WS2 QDs-embedded for CT/MSOT/MR imaging and thermoradiotherapy of hypoxic cancer. Biomaterials, 220: 119405, 2019.
- [30] Ren CC, Cheng Y, Li W, Liu P, Yang LF, Lu QL, Xu M, Tan FP, Li J*, Li N*. Ultra-small Bi2S3 nanodots-doped reversible Fe (Ⅱ/Ⅲ)-based hollow mesoporous prussian blue nanocubes for amplified tumor oxidative stress augmented photo-/radiotherapy, Biomaterials Science, 8, 1981-1995, 2020.
- [31] Yang LF, Lu QL, Ren CC, Xu M, Song YL, Liu P, Li W, Wang XX*, Li N*. Rod-shape inorganic biomimetic mutual-reinforcing MnO2-Au nanozymes for catalysis-enhanced hypoxic tumor therapy, Nano Research, 13 (8): 2246-2258, 2020.
- [32] Xu M, Lu QL, Song YL, Yang LF, Ren CC, Li W, Liu P, Wang YL, Zhu Y, Li N*. NIR-II driven plasmon-enhanced cascade reaction for tumor microenvironment-regulated catalytic therapy based on bio-breakable Au-Ag nanozyme, Nano Research, 13 (8): 2118-2129, 2020.
- [33] Liu P, Wang YD, Liu Y, Tan FP, Li JN*, Li N*. S-Nitrosothiols loaded mini-sized Au@silica nanorod for collagen depletion and mitochondrial damage in solid tumor treatment, Theranostics, 10 (15): 6774-6789, 2020.
- [34] Li W, Wang SY, Ren CC, Liu P, Lu QL, Yang LF, Song YL, Xu M, Tan FP, Yu M*, Li N*. Exo/Endogenous dual-augmented chemodynamic therapy based on bio-reducible and bio-breakable copper (Ⅱ)-based truncated octahedron, Chemical Engineering Journal, 396: 125280, 2020.
- [35] Xu M, Lu QL, Song YL, Yang LF, Li JN*, Li N*. Enhanced Bax upregulating in mitochondria for deep tumor therapy based on SO2 prodrug loaded Au–Ag hollow nanotriangles, Biomaterials, 250: 120076, 2020.
- [36] Song YL, Yang LF, Xu M, Lu QL, Li W, Ren CC, Liu P, Wang YL, Zhu Y, Tan FP, Li N*. Boosted photocatalytic activity induced NAMPT-regulating therapy based on elemental bismuth-humic acids heterojunction for inhibiting tumor proliferation/migration/inflammation, Biomaterials, 254: 120140, 2020.
- [37] Lu QL, Lu T, Xu M, Yang LF, Song YL, Li N*, SO2 prodrug doped nanorattles with extra-high drug payload for “collusion inside and outside” photothermal/pH triggered - gas therapy, Biomaterials, 257: 120236, 2020.
- [38] Xu M#, Song YL#, Wang JP**, Li N*. Anisotropic transition metal–based nanomaterials for biomedical applications, View, 2:20200154, 2021.
- [39] Song YL#, Jing HQ#, Vong LB, Wang JP**, Li N*. Recent advances in targeted stimuli-responsive nano-based drug delivery systems combating atherosclerosis, Chinese Chemical Letters, doi.org/10.1016/j.cclet.2021.10.055, 2021.
- [40] Li W, Song YL, Liang XY, Zhou Y, Xu M, Lu Q, Wang XX**, and Li N*. Mutual-reinforcing sonodynamic therapy against rheumatoid arthritis based on sparfloxacin sonosensitizer doped concave-cubic rhodium nanozyme, Biomaterials, 276: 121063, 2021.
- [41] Xu M, Zhou Y, Ren CC, Liang XY, Li N*. Palladium hydride nanopocket cubes and their H2-therapy function in amplifying inhibition of foam cells to attenuate atherosclerosis, Advanced Functional Materials, 2104892, 2021.
- [42] Lu Q, Zhou Y, Xu M, Liang XY, Jing HQ, Wang XX*, Li N*. Sequential delivery for hepatic fibrosis treatment based on carvedilol loaded star-like nanozyme, Journal of Controlled Release, 341:247-260, 2022.
- [43] Song YL, Li W, Jing HQ, Liang XY, Zhou Y, Li N*, Feng SQ*.Spatiotemporal sonodynamic therapy for the treatment of rheumatoid arthritis based on Z-scheme heterostructure sonosensitizer of HO-1 inhibitor jointed bismuth nanotriangle. Chemical Engineering Journal, 438:135558, 2022.
- [44] Wang SY, Zhou Y, Liang XY, Xu M, Li N*, Zhao K*. Platinum-Cerium bimetallic nano-raspberry for atherosclerosis treatment via synergistic foam cell inhibition and P2Y12 targeted antiplatelet aggregation, Chemical Engineering Journal, 430: 132859, 2022.
- Books
- [1] Li N, Tan FP, Zhang J*. Advances in medicine and biology, Nova Science Publishers, ISBN: 978-1-62808-826-7, 2013.
- [2] Yu M, Li N*, Shuai XT*. Photosensitizers: types, uses and selected research, Nova Science Publishers, ISBN: 978-1-53610-173-7, 2016.
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- [3] Wang JP, Tan XX, Pang XJ, Sun Q, Liu L, You Q, Tan FP, Li N*. Nanocarrier systems for drug delivery. Nova Science Publishers, ISBN: 978-1-53610-098-3, 2016.
- [4] Sun Q, Li N*. Liposomes: Historical, Clinical and Molecular Perspectives. Nova Science Publishers, ISBN: 978-1-53612-132-2, 2017.
- [5] You Q, Li N*. Photodynamic Therapies (PDT):Principles, Mechanisms, and Applications. Nova Science Publishers, ISBN: 978-1-53611-912-1, 2017.
- [6] Wang JP, Tan XX, Pang XJ, You Q, Liu L, Sun Q, Tan FP, Li N*. Theranostics and Image Guided Drug Delivery. Royal Society of Chemistry, ISBN: 978-1-78262-466-0, 2018.
- [7] Xu M, Li N*. Metal-based nanocontainers for drug delivery in tumor therapy//Smart Nanocontainers. Elsevier, ISBN: 978-0-12816-891-2, 2019