教育经历
· 1994.9 - 1997.6
Saarland University Med. School, Homburg, Germany - Medical Biochemistry - 博士
· 1997.9 - 2000.6
Saarland University, Germany - Biochemistry - Postdoctoral
· 1987.9 - 1994.6
Saarland University, Germany - Science Chemistry - 硕士
工作经历
· 2012.9 - 2014.6
Department of Biochemistry, Saarland University, Germany → Lecturer & Senior Scientist
· 2008.9 - 2012.6
PomBioTech GmbH, Germany → CEO
· 2004.9 - 2008.6
Department of Biochemistry, Saarland University, Germany → Senior Scientist (C2)
· 2001.9 - 2004.6
Department of Biochemistry, Saarland University, Germany → Senior Scientist (C1)
研究方向
· A primary aim is to search for compounds that can act as CYP4Z1-activated prodrugs (right figure) and have potential for treatment of breast cancer.
· In addition, additional substrates of this enzyme that are both structurally different and far better suited to screening procedures than fatty acids have been identified
· This is expected to aid doctors in choosing the correct dosage for patients. In the second area, the group has successfully identified CYP4Z1 to be a fatty acid in-chain hydroxylase.
· A primary goal in the first area involves systematic testing of all variants of drug metabolizing cytochrome P450 enzymes (CYPs or P450s; see left figure below) and UDP glycosyltransferases (UGTs) identified in Chinese patients.
· 2) investigation of human CYP4Z1 and the treatment of breast cancer.
· 1) Human drug metabolizing enzymes