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Matthias Bureik

性别:

职称:教授

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教育经历

  • · 1994.9 - 1997.6

    Saarland University Med. School, Homburg, Germany   - Medical Biochemistry   - 博士

  • · 1997.9 - 2000.6

    Saarland University, Germany   - Biochemistry   - Postdoctoral

  • · 1987.9 - 1994.6

    Saarland University, Germany   - Science Chemistry   - 硕士

工作经历

  • · 2012.9 - 2014.6

     Department of Biochemistry, Saarland University, Germany → Lecturer & Senior Scientist 

  • · 2008.9 - 2012.6

     PomBioTech GmbH, Germany → CEO 

  • · 2004.9 - 2008.6

     Department of Biochemistry, Saarland University, Germany → Senior Scientist (C2) 

  • · 2001.9 - 2004.6

     Department of Biochemistry, Saarland University, Germany → Senior Scientist (C1) 

研究方向

  • · A primary aim is to search for compounds that can act as CYP4Z1-activated prodrugs (right figure) and have potential for treatment of breast cancer.

  • ·  In addition, additional substrates of this enzyme that are both structurally different and far better suited to screening procedures than fatty acids have been identified

  • · This is expected to aid doctors in choosing the correct dosage for patients. In the second area, the group has successfully identified CYP4Z1 to be a fatty acid in-chain hydroxylase.

  • · A primary goal in the first area involves systematic testing of all variants of drug metabolizing cytochrome P450 enzymes (CYPs or P450s; see left figure below) and UDP glycosyltransferases (UGTs) identified in Chinese patients.

  • · 2) investigation of human CYP4Z1 and the treatment of breast cancer.

  • ·  1) Human drug metabolizing enzymes

学术成果

著作成果