Yunzi Luo, PI of Center for frontier science of synthetic biology, Tianjin University. Prof. Luo graduated from Tianjin University with a bachelor's degree in 2008 and a doctor's degree from University of Illinois at Urbana Champaign in 2014. From June 2014 to March 2015, she worked as a postdoctoral researcher in the Institute of biological genome, University of Illinois at Urbana Champaign. From 2015 to 2019, she was a researcher in the State Key Laboratory of Biotherapy, Sichuan University. Since 2019, she has been a professor in school of chemical engineering, Tianjin University. In 2016, she was selected as one of the National Talent program. At present, she is a member of the synthetic biology Committee of the Chinese society of bioengineering, a member of the young scholars working committee of the Chinese biochemical industry, and a member of the youth working committee of the Chinese bioengineering Association.

• Prof. Luo’s laboratory is mainly engaged in the optimization and transformation of gene editing tools by using synthetic biology technology, and applied these tools to the new drug development.

• the National Talent program

• 30. Zengyi Shao, Guodong Rao, Chun Li, Zhanar Abil, Yunzi Luo, Huimin Zhao*. Refactoring the silent spectinabilin gene cluster using a plug-and-play scaffold[J]. ACS Synthetic Biology.2013; 2(11): 662-669.
• 29. Ryan E. Cobb, Yunzi Luo, Todd Freestone, Huimin Zhao. Drug discovery and development via synthetic biology[M]. Synthetic Biology. 2013; 183-206.
• 28. Zengyi Shao, Yunzi Luo, Huimin Zhao*. DNA assembler method for construction of zeaxanthin producing strains of Saccharomyces cerevisiae[M]. Methods in Molecular Biology. 2012; 898, 251-262.
• 27. Jinglin Li , Yunzi Luo, Jung-Kul Lee, Huimin Zhao*. Cloning and characterization of a type III polyketide synthase from Aspergillus niger[J]. Bioorganic & Medicinal Chemistry Letters. 2011; 21, 6085-6089.
• 26. Zengyi Shao, Yunzi Luo, Huimin Zhao*. Rapid characterization and engineering of natural product biosynthetic pathways via DNA assembler[J]. Molecular Biosystems.2011; 7, 1056–1059.
• 25. Boxuan Zeng, Mingdong Yao, Wenhai Xiao, Yunzi Luo, Ying Wang*, Yingjin Yuan. Endogenous 2μ plasmid editing for pathway engineering in Saccharomyces cerevisiae[J]. Frontiers in Microbiology. 2021; 12:631462. doi: 10.3389/fmicb.2021.631462.
• 24. Min Zhao#, Yunhua Zheng#, Qiyuan Zhao#, Wei Zheng, Jianhong Yang, Heying Pei, Ling Liu, Kongjun Liu, Linlin Xue, Dexin Deng, Lun Wang, Xu Ma, Suhong Fu, Aihua Peng, Minghai Tang, Yunzi Luo, Haoyu Ye*, Lijuan Chen*. Synthesis and evaluation of new compounds bearing 3-(4-aminopiperidin-1-yl)methyl magnolol scaffold as anticancer agents for the treatment of non-small cell lung cancer via targeting autophagy[J]. European Journal of Medicinal Chemistry. 2021; 209:112922.
• 23. Tong Si, Yunzi Luo, Zehua Bao, Huimin Zhao*. RNAi-assisted genome evolution in saccharomyces cerevisiae for complex phenotype engineering[J]. ACS Synthetic Biology. 2014; 4(3): 283-291.
• 22. Tong Si, Yunzi Luo, Han Xiao, Huimin Zhao*. Utilizing an endogenous pathway for 1-butanol production in Saccharomyces cerevisiae[J]. Metabolic Engineering. 2014; 22, 60-68.
• 21. Jing Liang#, Yunzi Luo#, Huimin Zhao*. Synthetic biology: putting synthesis into biology[J]. Wiley Interdisciplinary Reviews-Systems Biology and Medicine. 2011; 3, 7–20.
• 20. Sheryl B. Rubin-Pitel#, Yunzi Luo#, Jung-Kul Lee and Huimin Zhao*. A diverse family of type III polyketide synthases in eucalyptus species[J]. Molecular BioSystems. 2010; 6, 1444–1446.
• 19. Yunzi Luo, Jung-Kul Lee, Huimin Zhao*. Challenges and opportunities in synthetic biology for chemical engineers[J]. Chemical Engineering Science. 2013; 103, 115-119.
• 18. Qun Zhou, Shuqing Ning, Yunzi Luo*. Coordinated regulation for nature products discovery and overproduction in Streptomyces[J]. Synthetic and Systems Biotechnology, 2020; 5(2):49-58.
• 17. Huayi Liu, Lian Wang, Yunzi Luo*. Blossom of CRISPR technologies and applications in disease treatment[J]. Synthetic and Systems Biotechnology, 2018; 3(4):217-228.
• 16. Qiyuan Zhao#, Liping Wang#, Yunzi Luo*. Recent advances in natural products exploitation in Streptomyces via synthetic biology. Engineering in Life Sciences. 2019; 19:452–462.
• 15. Yeyi Kan#, Lihui He#, Yunzi Luo*, Rui Bao*. IsPETase is a novel biocatalyst for poly(ethylene terephthalate) (PET) hydrolysis[J]. Chembiochem. 2021; 22(10):1706-1716.
• 14. Bing Liu#, Lihui He#, Liping Wang, Tao Li, Changcheng Li, Huayi Liu, Yunzi Luo*, Rui Bao*. Protein crystallography and site-direct mutagenesis analysis of the poly(ethylene terephthalate) hydrolase PETase from Ideonella sakaiensis[J]. Chembiochem. 2018; 19(14): 1471-1475.
• 13. Zhenyu Liu#, Yatong Zhao# Chaoqun Huang, Yunzi Luo*. Recent Advances in Silent Gene Cluster Activation in Streptomyces[J]. Frontiers in Bioengineering and Biotechnology. 2021; 9:632230. doi: 10.3389/fbioe.2021.632230.
• 12. Jing Yang#, Yujuan Tian#, Huayi Liu, Yeyi Kan, Yi Zhou, Ying Wang and Yunzi Luo*. Harnessing the endogenous 2μplasmid of Saccharomyces cerevisiae for pathway construction[J]. Frontiers in Microbiology. 2021; doi: 10.3389/fmicb.2021.679665.
• 11. Dan Zhang#, Xixi Wang#, Yang Ye, Yu He, Fuqiang He, Yongqiang Tian, Yunzi Luo*, Shufang Liang*. Label-free proteomic dissection on dptP-deletion mutant uncovers dptP involvement in strain growth and daptomycin tolerance of Streptomyces roseosporus[J]. Microbial Biotechnology. 2021; 14(2):708-725.
• 10. Jun Zhang#, Dan Zhang#, Jie Zhu, Huayi Liu, Shufang Liang* and Yunzi Luo*. Efficient multiplex genome editing in Streptomyces via engineered CRISPR-Cas12a systems[J]. Frontiers in Bioengineering and Biotechnology. 2020; doi.org/10.3389/fbioe.2020.00726.
• 9. Hongbin Yu#, Zheng Wang#, Hanyue Xu, Jiusi Guo, Qingge Ma, Xiangxu Mu, Yunzi Luo*. A method for absolute protein expression quantity measurement employing insulator riboJ[J]. Engineering. 2018; 4(6): 881-887.
• 8. Bing Liu#, Chang Zhao#, Qianyin Xiang, Ninglin Zhao, Yunzi Luo*, Rui Bao*. Structural and biochemical studies of the glycosyltransferase Bs-YjiC from Bacillus subtilis[J]. International Journal of Biological Macromolecules. 2021;166:806-817.
• 7. Huayi Liu, Yujuan Tian, Yi Zhou, Yeyi Kan, Tingting Wu, Wenhai Xiao, Yunzi Luo*. Multi-modular engineering of Saccharomyces cerevisiae for high-titre production of tyrosol and salidroside[J]. Microbial Biotechnology. 2020, doi:10.1111/1751-7915, 13667.
• 6. Liping Wang#, Haojun Wang#, Huayi Liu, Qiyuan Zhao, Bing Liu, Lian Wang, Jun Zhang, Jie Zhu, Rui Bao, Yunzi Luo*. Improved CRISPR‐Cas12a‐assisted one‐pot DNA editing method enables seamless DNA editing[J]. Biotechnology and Bioengineering. 2019, 116(6):1463-1474.
• 5. Yunzi Luo, Lu Zhang, Katherine W. Barton, and Huimin Zhao*. Systematic identification of a panel of strong constitutive promoters from streptomyces albus[J]. ACS Synthetic Biology.2015; 4(9):1001-1010.
• 4. Yunzi Luo#, Ryan E Cobb#, and Huimin Zhao*. Recent advances in natural product discovery[J]. Current Opinion in Biotechnology. 2014; 30, 230-237.
• 3. Yunzi Luo, Behnam Enghiad, and Huimin Zhao*. New tools for reconstruction and heterologous expression of natural product biosynthetic gene clusters[J]. Natural Product Reports. 2016; 33(2), 174-182.
• 2. Yunzi Luo, Hua Huang, Jing Liang, Meng Wang, Lu Lu, Zengyi Shao, Ryan E. Cobb and Huimin Zhao*. Activation and characterization of a cryptic polycyclic tetramate macrolactam biosynthetic gene cluster[J]. Nature Communications. 2013; 4, 2894.
• 1. Yunzi Luo#, Bing-Zhi Li#, Duo Liu#, Lu Zhang, Yan Chen, Bin Jia, Boxuan Zeng, Huimin Zhao and Yingjin Yuan*. Engineered biosynthesis of natural products in heterologous hosts[J]. Chemical Society Reviews. 2015; 44(15): 5265-5290.