叶升，天津大学讲席教授，国家杰出青年，国家创新人才推进计划中青年科技创新领军人才，教育部新世纪优秀人才。1991年本科毕业于厦门大学生物系，1996年在中国科学院生物物理研究所获得博士学位。目前作为课题负责人在研课题有科技部重大科学研究计划、国家自然科学基金重点、杰青、面上项目等。叶升博士实验室的目标是在原子水平上“看”到蛋白质的结构、运动和相互作用，在此基础上结合功能实验对生命现象做出精确和定量的描述，同时开展蛋白质设计应用。代表性论文以通讯作者发表在《Science》、《Nature Structural & Molecular Biology》、《eLife》、《Nature Communications》、《Science Advances》、《Cell Reports》、《Journal of Biological Chemistry》、《Analytical Chemistry》等自然指数（Nature Index）期刊，以及《Cell Research》、《National Science Review》、《Cell Discovery》、《Protein & Cell》等中国最具国际影响力的学术期刊。并被国际同行发表专文正面评述。

代表性论文：

1. Qian Y, Wang J, Yang L, Liu Y, Wang L, Liu W, Lin Y, Yang H, Ma L, Ye S*, Wu S*, Qiao A* (2022) Activation and signaling mechanism revealed by GPR119-G_s complex structures. Nat Commun, 13:7033

2. Xu B, Zhang M, Zhang B, Chi W, Ma X, Zhang W, Dong M, Sheng L, Zhang Y, Jiao W, Shan Y, Chang W, Wang P, Wen S, Pei D, Chen L*, Zhang X*, Yan H*, Ye S* (2022) Embigin facilitates monocarboxylate transporter 1 localization to the plasma membrane and transition to a decoupling state. Cell Rep, 40:111343

3. Guan F, Chai H, Dong W, Guo R, Chen Z, Ren Z*, Li Y*, Ye S* (2022) The allosteric gating mechanism of the MthK channel. Natl Sci Rev, 9:nwac072

4. Zhang B, Jin Q, Xu L, Li N, Meng Y, Chang S, Zheng X, Wang J, Chen Y, Neculai D, Gao N, Zhang X*, Yang F*, Guo J*, Ye S* (2020) Cooperative transport mechanism of human monocarboxylate transporter 2. Nat Commun, 11:2429

5. Jin Q, Zhang B, Zheng X, Li N, Xu L, Xie Y, Song F, Bhat EA, Chen Y, Gao N, Guo J*, Zhang X*, Ye S* (2020) Cryo-EM Structures of Human Pannexin 1 Channel. Cell Res, 30:449-451

6. Liu S, Chang S, Han B, Xu L, Zhang M, Zhao C, Yang W, Wang F, Li J*, Delpire E*, Ye S*, Bai XC*, Guo J* (2019) Cryo-EM structures of the human cation-chloride cotransporter KCC1. Science, 366:505-508

7. Liu S, Xu L, Guan F, Liu YT, Cui Y, Zhang Q, Zheng X, Bi GQ, Zhou ZH*, Zhang X*, Ye S* (2018) Cryo-EM structure of the human a5b3 GABA_A receptor. Cell Res, 28:958-961

8. Guan F, Yu J, Yu J, Liu Y, Li Y, Feng XH, Huang KC, Chang Z*, Ye S* (2018) Lateral interactions between protofilaments of the bacterial tubulin homolog FtsZ are essential for cell division. eLife, 7:e35578

9. Li Y, Hsin J, Zhao L, Cheng Y, Shang W, Huang KC, Wang HW, Ye S* (2013). FtsZ Protofilaments use a hinge-opening mechanism for constrictive force generation. Science, 341:392-5

10. Ye S*, Li Y, Jiang Y* (2010). Novel insights into ion selectivity from high resolution structures of an open K⁺ channel pore. Nat Struct Mol Biol, 17:1019-23.

• 蛋白质设计
• 蛋白质结构与功能

• 国家杰出青年基金（2015）
• 国家创新人才推进计划中青年科技创新领军人才（2015）
• 教育部新世纪优秀人才（2010）

• 发表论文 (*通讯作者)
• 2022年
• 1. Qian Y, Wang J, Yang L, Liu Y, Wang L, Liu W, Lin Y, Yang H, Ma L, Ye S*, Wu S*, Qiao A* (2022) Activation and signaling mechanism revealed by GPR119-Gs complex structures. Nat Commun, 13:7033
• 2. Xu B, Zhang M, Zhang B, Chi W, Ma X, Zhang W, Dong M, Sheng L, Zhang Y, Jiao W, Shan Y, Chang W, Wang P, Wen S, Pei D, Chen L*, Zhang X*, Yan H*, Ye S* (2022) Embigin facilitates monocarboxylate transporter 1 localization to the plasma membrane and transition to a decoupling state. Cell Rep, 40:111343
• 3. Su N, Zhu A, Tao X, Ding ZJ, Chang S, Ye F, Zhang Y, Zhao C, Chen Q, Wang J, Zhou CY, Guo Y, Jiao S, Zhang S, Wen H, Ma L, Ye S, Zheng SJ, Yang F, Wu S, Guo J (2022) Structures and mechanisms of the Arabidopsis auxin transporter PIN3. Nature, 609:616-621
• 4. Guan F, Chai H, Dong W, Guo R, Chen Z, Ren Z*, Li Y*, Ye S* (2022) The allosteric gating mechanism of the MthK channel. Natl Sci Rev, 9:nwac072
• 5. Wang H, Xiao Y, Chen X, Zhang M, Sun G, Wang F, Wang L, Zhang H, Zhang X, Yang X, Li W, Wei Y, Yao D, Zhang B, Li J, Cui W, Wang F, Chen C, Shen W, Su D, Bai F, Huang J, Ye S, Zhang L, Ji X, Wang W, Wang Z, Hochstrasser M, Yang H (2022) Crystal Structures of Wolbachia CidA and CidB Reveal Determinants of Bacteria-induced Cytoplasmic Incompatibility and Rescue. Nat Commun, 13:1608
• 6. Wu X, Wang Y, Cheng L, Ni F, Zhu L, Ma S, Huang B, Ji M, Hu H, Li Y, Xu S, Shi H, Zhang D, Liu L, Nawaz W, Hu Q, Ye S*, Liu Y*, Wu Z* (2022) Short-term instantaneous prophylaxis and efficient treatment against SARS-CoV-2 in hACE2 mice conferred by an intranasal nanobody (Nb22). Front Immunol, 13:865401
• 7. Wang Y, Xu B, Ma S, Wang H, Shang L, Zhu C*, Ye S* (2022) Discovery of SARS-CoV-2 3CLPro Peptidomimetic Inhibitors through the Catalytic Dyad Histidine-Specific Protein-Ligand Interactions. Int J Mol Sci, 23:2392
• 2021年
• 1. Lv D, Li J*, Ye S* (2021) The assembly switch mechanism of FtsZ filament revealed by all-atom molecular dynamics simulations and coarse-grained models. Front Microbiol, 12:639883
• 2. Li X, Zhang Q, Guo P, Fu J, Mei L, Lv D, Wang J, Lai D, Ye S, Yang H, Guo J (2021) Molecular Basis for Ligand Activation of the Human KCNQ2 channel. Cell Res, 31:52-61
• 2020年
• 1. Xie Y, Chang S, Zhao C, Wang F, Liu S, Wang J, Delpire E*, Ye S*, Guo J* (2020) Structures and an activation mechanism of human potassium-chloride cotransporters. Sci Adv, 6:eabc5883
• 2. Liu J, Wan F, Jin Q, Li X, Bhat EA, Guo J, Lei M, Guan F*, Wu J*, Ye S* (2020) Cryo-EM Structures of Human Calcium Homeostasis Modulator 5. Cell Discov, 6:81
• 3. Zhang Z, Fang X, Wu X, Ling L, Chu F, Li J, Wang S, Zang J, Zhang B, Ye S, Zhang L, Yang B, Lin S, Huang H, Wang A, Zhou F (2020) Acetylation-Dependent Deubiquitinase OTUD3 Controls MAVS Activation in Innate Antiviral Immunity. Mol Cell, 79:304-319e7
• 4. Zhang B, Jin Q, Xu L, Li N, Meng Y, Chang S, Zheng X, Wang J, Chen Y, Neculai D, Gao N, Zhang X*, Yang F*, Guo J*, Ye S* (2020) Cooperative transport mechanism of human monocarboxylate transporter 2. Nat Commun, 11:2429
• 5. Jin Q, Zhang B, Zheng X, Li N, Xu L, Xie Y, Song F, Bhat EA, Chen Y, Gao N, Guo J*, Zhang X*, Ye S* (2020) Cryo-EM Structures of Human Pannexin 1 Channel. Cell Res, 30:449-451
• 6. 张艺，叶升* (2020)还原型谷胱甘肽生理功能及其临床应用. 生命的化学, 40:2226-2235
• 2019年
• 1. Liu S, Chang S, Han B, Xu L, Zhang M, Zhao C, Yang W, Wang F, Li J*, Delpire E*, Ye S*, Bai XC*, Guo J* (2019) Cryo-EM structures of the human cation-chloride cotransporter KCC1. Science, 366:505-508
• 2. Wang JW, Gao J, Wang HF, Jin QH, Rao B, Deng W, Cao Y, Lei M, Ye S*, Fang Q* (2019) Miniaturization of the Whole Process of Protein Crystallographic Analysis by a Microfluidic Droplet Robot: From Nanoliter-Scale Purified Proteins to Diffraction-Quality Crystals. Anal Chem, 91:10132-10140
• 3. Luo Y*, Ye S*, Li X*, Lu W* (2019) Emerging Structure-Function Paradigm of Endocrine FGFs in Metabolic Diseases. Trends Pharmacol Sci, 40:142-153
• 2018年
• 1. Liu S, Xu L, Guan F, Liu YT, Cui Y, Zhang Q, Zheng X, Bi GQ, Zhou ZH*, Zhang X*, Ye S* (2018) Cryo-EM structure of the human 53 GABAA receptor. Cell Res, 28:958-961
• 2. Guan F, Yu J, Yu J, Liu Y, Li Y, Feng XH, Huang KC, Chang Z*, Ye S* (2018) Lateral interactions between protofilaments of the bacterial tubulin homolog FtsZ are essential for cell division. eLife, 7:e35578
• 2017年
• 1. Zhang Z, Fan Y, Xie F, Zhou H, Jin K, Shao L, Shi W, Fang P, Yang B, van Dam H, Ten Dijke P, Zheng X, Yan X, Jia J, Zheng M, Jin J, Ding C, Ye S, Zhou F, Zhang L (2017) Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7. Nat Commun, 8:2116
• 2. Liang C, Chen Q, Yi Q, Zhang M, Yan H, Zhang B, Zhou L, Zhang Z, Qi F, Ye S, Wang F (2017) A kinase-dependent role for Haspin in antagonizing Wapl and protecting mitotic centromere cohesion. EMBO Rep, 19:43-56
• 3. Luo Y, Ye S, Chen X, Gong F, Lu W, Li X (2017) Rush to the fire: FGF21 extinguishes metabolic stress, metaflammation and tissue damage. Cytokine Growth Factor Rev, 38:59-65
• 4. Yu J, Wang X, Xu T, Jin Q, Duan J, Wu J, Wu H, Xu T*, Ye S* (2017) A rational approach to enhancing antibody Fc homodimer formation for robust production of antibody mixture in a single cell line. J Biol Chem, 292:17885-17896
• 5. Yu Y, Gu S, Li W, Sun C, Chen F, Xiao M, Wang L, Xu D, Li Y, Ding C, Xia Z, Li Y, Ye S, Xu P, Zhao B, Qin J, Chen YG, Lin X, Feng XH (2017) Smad7 enables STAT3 activation and promotes pluripotency independent of TGF-β signaling. Proc Natl Acad Sci USA, 114:10113-10118
• 6. Si Y, Ji X, Cao X, Dai X, Xu L, Zhao H, Guo X, Yan H, Zhang H, Zhu C, Zhou Q, Tang M, Xia Z, Li L, Cong YS, Ye S, Liang T, Feng XH, Zhao B (2017) Src Inhibits the Hippo Tumor Suppressor Pathway through Tyrosine Phosphorylation of Lats1. Cancer Res, 77:4868-4880
• 7. Liu S, Chen S, Li X, Wu S, Zhang Q, Jin Q, Hu L, Zhou R, Yu Z, Meng F, Wang S, Huang Y, Ye S, Shen L, Xia Z, Zou J, Feng XH, Xu P (2017) Lck/Hck/Fgr-Mediated Tyrosine Phosphorylation Negatively Regulates TBK1 to Restrain Innate Antiviral Responses. Cell Host Microbe, 21:754-768
• 8. Liang YR, Zhu LN, Gao J, Zhao HX, Zhu Y*, Ye S*, Fang Q* (2017) 3D-Printed High-Density Droplet Array Chip for Miniaturized Protein Crystallization Screening under Vapor Diffusion Mode. ACS Appl Mater Interfaces, 9:11837-11845
• 9. Zhou L, Liang C, Chen Q, Zhang Z, Zhang B, Yan H, Qi F, Zhang M, Yi Q, Guan Y, Xiang X, Zhang X, Ye S, Wang F (2017) The N-Terminal Non-Kinase-Domain-Mediated Binding of Haspin to Pds5B Protects Centromeric Cohesion in Mitosis. Curr Biol, 27:992-1004
• 2016年
• 1. Gu M, Liu Z, Lai R, Liu S, Lin W, Ouyang C, Ye S, Huang H, Wang X (2016) RKIP and TBK1 form a positive feedback loop to promote type I interferon production in innate immunity. EMBO J, 35:2553-2565
• 2. Meng F, Zhou R, Wu S, Zhang Q, Jin Q, Zhou Y, Plouffe SW, Liu S, Song H, Xia Z, Zhao B, Ye S, Feng XF, Guan KL, Zou J, Xu P (2016). Mst1 shuts off cytosolic antiviral defense through IRF3 phosphorylation. Genes Dev, 30:1086-100
• 2015年
• 1. Banerjee S, Ren Y, Zheng M, Wei T, Zhou Z, Yu P, Guan F, Wei X, Ye S, Yan S, Raff M, Qi M (2015). Next generation sequencing detection and characterization of a heterozygous novel splice junction mutation in the 2B domain of KRT1 in a family with diffuse palmoplantar keratoderma. Exp Dermatol, 24:152-155
• 2. Kimani JK, Wei T, Choi K, Li Y, Yu P, Ye S, Huang X, Qi M (2015). Functional analysis of novel splicing and missense mutations identified in the ASS1 gene in classical citrullinemia patients. Clin Chim Acta, 438:323-9
• 2014年
• 1. Guo R, Zeng W, Cui H, Chen L, Ye S* (2014). Ionic interactions of Ba2+ blockades in the MthK K+ channel. J Gen Physiol, 144:193-200
• 2. Zhu Y, Zhu LN, Guo R, Cui HJ, Ye S, Fang Q (2014). Nanoliter-scale protein crystallization and screening with a microfluidic droplet robot. Sci Rep, 4:5046
• 2013年
• 1. Xiao PF, Guo R, Huang SQ, Cui HJ, Ye S*, Zhang ZY* (2014). Discovery of dipeptiyl peptidase IV (DPP4) inhibitors based on a novel indole scaffold. Chin Chem Lett, 25:673-6
• 2. Lin C, Guo X, Lange S, Liu J, Ouyang K, Yin X, Jiang L, Cai Y, Mu Y, Sheikh F, Ye S, Chen J, Ke Y, Cheng H (2013). Cypher/ZASP is a novel A kinase anchoring protein. J Biol Chem, 288:29403-13
• 3. Li Y, Hsin J, Zhao L, Cheng Y, Shang W, Huang KC, Wang HW, Ye S* (2013). FtsZ Protofilaments use a hinge-opening mechanism for constrictive force generation. Science, 341:392-5
• 2012年
• 1. Dong W, Lu W, McKeehan WL, Luo Y*, Ye S* (2012). Structural Basis of Heparan Sulfate-Specific Degradation by Heparinase III. Protein Cell, 3:950-61
• 2. Kong C, Zeng W, Ye S, Chen L, Sauer DB, Lam Y, Derebe MG, Jiang Y (2012). Distinct gating mechanisms revealed by the structures of a multi-ligand gated K(+) channel. Elife, 1:e00184
• 3. Chiang PW, Wang J, Chen Y, Fu Q, Zhong J, Chen Y, Yi X, Wu R, Gan H, Shi Y, Chen Y, Barnett C, Wheaton D, Day M, Sutherland J, Heon E, Weleber RG, Gabriel LA, Cong P, Chuang K, Ye S, Sallum JM, Qi M (2012). Exome sequencing identifies NMNAT1 mutations as a cause of Leber congenital amaurosis. Nat Genet. 44:972-4
• 2011年
• 1. Shi N, Zeng W, Ye S, Li Y, Jiang Y (2011). Crucial Points within the Pore as Determinants of K(+) Channel Conductance and Gating. J Mol Biol, 411:27-35
• 2. Cao Y, Jin X, Huang H, Derebe MG, Levin EJ, Kabaleeswaran V, Pan Y, Punta M, Love J, Weng J, Quick M, Ye S, Kloss B, Bruni R, Martinez-Hackert E, Hendrickson WA, Rost B, Javitch JA, Rajashankar KR, Jiang Y, Zhou M (2011). Crystal structure of a potassium ion transporter, TrkH. Nature, 471:336-40
• 2010年
• 1. Ye S*, Li Y, Jiang Y* (2010). Novel insights into ion selectivity from high resolution structures of an open K+ channel pore. Nat Struct Mol Biol, 17:1019-23.
• 2. Wu Y, Yang, Y, Ye S, Jiang Y (2010). Structure of the Gating Ring from the Human Large-conductance Ca2+-gated K+ Channel. Nature, 466:393-7
• 2010年之前
• 1. Ye S, Li Y, Chen L, Jiang Y (2006). Crystal structures of a Ligand-free MthK gating ring: Insights into the ligand gating mechanism of K+ channel. Cell, 126:1161-73
• 2. Luo Y, Ye S, Kan M, McKeehan WL (2006). Control of FGF7- and FGF1-induced mitogenesis and downstream signaling by distinct heparin octasaccharide motifs. J Biol Chem, 281:21052-61
• 3. Shi N, Ye S, Alam A, Chen L, Jiang Y (2006). Atomic Structure of a Na+ and K+ Conducting Channel. Nature, 440:570-4
• 4. Luo Y, Ye S, Kan M, McKeehan WL (2006). Structural Specificity in a FGF7-Affinity Purified Heparin Octasaccharide Required for Formation of a Complex with FGF7 and FGFR2IIIb. J Cell Biochem, 97:1241-58
• 5. Paricharttanakul NM, Ye S, Menefee AL, Javid-Majd F, Sacchettini JC, Reinhart GD (2005). Kinetic and structural Characterization Phosphofructokinase from Lactobacillus bulgaricus. Biochemistry, 44:15280-6
• 6. Ye S, Vakonakis I, Ioerger TR, LiWang AC, Sacchettini JC (2004). Crystal structure of circadian clock protein KaiA from synechococcus elongatus. J Biol Chem. 279:20511-8
• 7. Aertgeerts K, Ye S, Shi L, Prasad SG, Witmer D, Chi E, Sang BC, Wijnands RA, Webb DR, Swanson RV (2004). N-linked glycosylation of dipeptidyl peptidase IV (CD26): Effects on enzyme activity, homodimer formation, and adenosine deaminase binding. Protein Sci. 13:145-54
• 8. Aertgeerts K, Ye S, Tennant MG, Kraus ML, Rogers J, Sang BC, Skene RJ, Webb DR, Prasad GS (2004). Crystal structure of human dipeptidyl peptidase IV in complex with a decapeptide reveals details on substrate specificity and tetrahedral intermediate formation. Protein Sci. 13:412-21
• 9. Ye S, von Delft F, Brooun A, Knuth MW, Swanson RV and McRee DE (2003). The Crystal Structure of Shikimate Dehydrogenase (AroE) Reveals a Unique NADPH Binding Mode. J Bacteriol. 185:4144-51
• 10. Bergstrom RC, Coombs GS, Ye S, Madison EL Goldsmith EJ and Corey DR (2003). Binding of nonphysiological protein and peptide substrates to proteases: differences between urokinase-type plasminogen activator and trypsin and contributions to the evolution of regulated proteolysis. Biochemistry. 42:5395-402
• 11. Ye S, Goldsmith EJ (2001). Serpins and Other Covalent Protease Inhibitors. Curr Opin Struct Biol, 11:740-5
• 12. Ye S, Cech AL, Belmares R, Bergstrom RC, Tong Y, Corey DR, Kanost MR, and Goldsmith EJ (2001). The structure of a Michaelis Serpin-Protease Complex. Nat Struct Biol, 8:979-83
• 13. Ye S, Luo Y, Lu W, Jones RB, Mohamedali KA, Linhardt RJ, Capila I, Toida T, Kan M, Pelletier H and McKeehan WL (2001). Structural Basis for Interaction of FGF-1, FGF-2 and FGF-7 with Different Heparan Sulfate Motifs. Biochemistry, 40:14429-39
• 14. Yang Z, Ye S, Jing GZ, Gui LL, Liang DC (1997). Crystal structure of an N-terminal fragment SNR141 of Staphylococcal nuclease R refined at 1.9 angstrom resolution. Prog Nat Sci, 9:617-22
• 15. Ye S, Wan ZL, Zhou B, Jing GZ, Liang DC (1997). Crystallization and preliminary X-ray analysis of SNR 141 - an N-terminal fragment of staphylococcal nuclease R. Chinese Science Bulletin, 42:983-5 (Chinese Ed.) 42:957-60 (Eng. Ed.)
• 16. Ye S, Wan ZL, Shi YZ, Zhou B, Jing GZ, Liang DC (1997). Crystallization and preliminary X-ray analysis of staphylococcal nuclease R. Acta Biophysica Sinica 13:7-10
• 17. Ye S, Wan ZL, Liu CG, Chang WR, Liang DC (1996). Crystal structure of (L-Arg)-B0 bovine insulin at 0.21 nm resolution. Science in China (Series C), 26:295-301 (Chinese Ed.) 39:465-73 (Eng. Ed.)