个人简介
叶升，天津大学讲席教授，国家杰出青年，国家万人计划中青年科技创新领军人才，教育部新世纪优秀人才。1991年本科毕业于厦门大学生物系，1996年在中国科学院生物物理研究所获得博士学位。目前作为课题负责人在研课题有科技部重大科学研究计划、国家自然科学基金重点、杰青、面上项目等。叶升博士实验室的目标是在原子水平上“看”到蛋白质的结构、运动和相互作用，在此基础上结合功能实验对生命现象做出精确和定量的描述，同时开展蛋白质设计应用。代表性论文以通讯作者发表在国际著名杂志如《Science》、《Nature Structural & Molecular Biology》、《Nature Communications》、《eLife》、《Cell Research》等上,并被国际同行发表专文正面评述。
代表性论文：
Lv D, Li J*, Ye S* (2021) The assembly switch mechanism of FtsZ filament revealed by all-atom molecular dynamics simulations and coarse-grained models. Front Microbiol, 12:639883
Liu J, Wan F, Jin Q, Li X, Bhat EA, Guo J, Lei M, Guan F*, Wu J*, Ye S* (2020) Cryo-EM Structures of Human Calcium Homeostasis Modulator 5. Cell Discov, 6:81
Zhang B, Jin Q, Xu L, Li N, Meng Y, Chang S, Zheng X, Wang J, Chen Y, Neculai D, Gao N, Zhang X*, Yang F*, Guo J*, Ye S* (2020) Cooperative transport mechanism of human monocarboxylate transporter 2. Nat Commun, 11:2429
Jin Q, Zhang B, Zheng X, Li N, Xu L, Xie Y, Song F, Bhat EA, Chen Y, Gao N, Guo J*, Zhang X*, Ye S* (2020) Cryo-EM Structures of Human Pannexin 1 Channel. Cell Res, 30:449-451
Liu S, Chang S, Han B, Xu L, Zhang M, Zhao C, Yang W, Wang F, Li J*, Delpire E*, Ye S*, Bai XC*, Guo J* (2019) Cryo-EM structures of the human cation-chloride cotransporter KCC1. Science, 366:505-508
Liu S, Xu L, Guan F, Liu YT, Cui Y, Zhang Q, Zheng X, Bi GQ, Zhou ZH*, Zhang X*, Ye S* (2018) Cryo-EM structure of the human a5b3 GABAA receptor. Cell Res, 28:958-961
Guan F, Yu J, Yu J, Liu Y, Li Y, Feng XH, Huang KC, Chang Z*, Ye S* (2018) Lateral interactions between protofilaments of the bacterial tubulin homolog FtsZ are essential for cell division. eLife, 7:e35578
Li Y, Hsin J, Zhao L, Cheng Y, Shang W, Huang KC, Wang HW, Ye S* (2013). FtsZ Protofilaments use a hinge-opening mechanism for constrictive force generation. Science, 341:392-5
Ye S*, Li Y, Jiang Y* (2010). Novel insights into ion selectivity from high resolution structures of an open K+ channel pore. Nat Struct Mol Biol, 17:1019-23.
Ye S, Li Y, Chen L, Jiang Y (2006). Crystal structures of a Ligand-free MthK gating ring: Insights into the ligand gating mechanism of K+ channel. Cell, 126:1161-73