School of Life Sciences
Professor
纳米生物医学
shengwang@tju.edu.cn
Rm 110, Bldg. 14
300072
Sheng Wang received his Ph.D. in Materials Science from Tianjin University in 2015. He then worked as a postdoctoral researcher at National Institutes of Health (NIH). In 2019, he joined the faculty of Tianjin University as a Professor. His current research focuses on the design and development of stimuli-responsive nanomaterials for biomedical applications.
Researcher ID: ABE-4580-2020 https://publons.com/researcher/4038128/sheng-wang/;
ORCID: 0000-0002-4797-5310 http://orcid.org/0000-0002-4797-5310;
- Ph. D.| Tianjin University| Materials science| 2015
- Bachelor's Degree| Tianjin University| Materials science and engineering| 2010
- Immunotherapy
- Ferroptosis
- Targeted Protein Degradation
- Nanomedicine
- BIO Integration Editorial Board Member
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2015.11-2019.9
 National Institutes of Health | Postdoctoral fellow  -
2019.11-Now
School of Life Sciences | Tianjin University | Professor 
- Papers
- [1] Yangfan Wang, Xiangyu Yang, Miya Zhang, Jiaqi Lei, Shaolong Qi, Kai Yang, Yongcan Li, Wenjie Zhang, Meiqi Cheng, Sheng Wang, Jinqun Gan, Fangfang Cao, Ruibing Wang, Guocan Yu. Supramolecular Microspheres Fabricated from Macrocycle-Incorporated Polymers and Their Biomedical Applications Based on Host-Guest Recognition. Small Methods 2025, 9, e01053.
- [2] Jiansen Li, Chen Cao, Xinlu Zhang, Xiaoqun Gong*, Sheng Wang*. A Hypoxia-Responsive Nanomedicine for Cancer Immunotherapy through Ligand Competition-Induced Dual-Prodrug Activation. J. Colloid Interface Sci. 2026, 701, 138774.
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- [3] Xu Zhang, Zhangzhi Song, Xinyu Zhang, Jianhua Zou*, Guocan Yu*, Xiaoyuan Chen*, Sheng Wang*. Unconventional PROTACs for Targeted Protein Degradation in Cancer Therapy. Angew. Chem. Int. Ed. 2025, 64, e202507702.
- [4] Shujing Xu, Yuewei Li, Jiansen Li, Suixin Xing, Xinlu Zhang, Xu Zhang, Lei Han*, Sheng Wang*. An Engineered Microbial Nanohybrid for Enhanced Photothermal-Chemodynamic Therapy through Controlled Gas Generation. J. Colloid Interface Sci. 2025, 699, 138220.
- [5] Xinlu Zhang, Yongxin Liu, Huan Li, Shutong Chen, Guocheng Wang, Xu Zhang, Chen Cao, Xiaoyuan Chen*, Sheng Wang*. A Hypoxia-Activated Copper Ion Nanoexchanger for Cancer Immunotherapy by in Situ Precise Production of Immunogenic Cell Death Inducer. Chin. Chem. Lett. 2025, 111404.
- [6] Shuang Zhao, Qiuting Zhang, Jiudi Sun, Shenghui Li, Sheng Wang*, Dianming Zhou*, Xiaoqun Gong*. Simply Engineered CrRNA with CRISPR/Cas12a System Enables Wide-Scope Nucleic Acid Biomarker Analysis. Nano Lett. 2025, 25, 8431-8441.
- [7] Xue Li, Xu Zhang*, Haizhen Guo, Zhetao Li, Lei Han*, Sheng Wang*. Photo-Activatable Prodrug Nanoparticles for Reactive Oxygen Species Amplification and Cooperative Cancer Therapy. Colloids Surf., B 2025, 253, 114775.
- [8] Xu Zhang, Xinlu Zhang, Qin Fan, Jiansen Li, Shitian Jia, Xiaoyuan Chen*, Sheng Wang*. Self-Accelerated Nanoregulators for Positive Feedback Ferroptosis-Immunotherapy. Small 2025, 21, 2408156.
- [9] Yongxin Liu, Xinlu Zhang, Xu Zhang*, Guocheng Wang, Xue Li, Suixin Xing, Chen Cao, Yuewei Li, Lei Han*, Sheng Wang*. Histone Deacetylase Inhibiting Nanoprodrugs for Enhanced Chemodynamic Therapy through Multistage Downregulating Glutathione. Int. J. Biol. Macromol. 2025, 305, 141184.
- [10] Suixin Xing, Xu Zhang*, Haizhen Guo, Shitian Jia, Shujing Xu, Yongxin Liu, Xue Li, Yuewei Li, Sheng Wang*. Polyprodrug-siRNA Nanoparticles for Chemodynamically Enhanced Ferroptosis Via Glutathione Peroxidase Downregulation. ACS Appl. Nano Mater. 2025, 8, 3558−3565.
- [11] Jiansen Li, Chen Cao, Xinlu Zhang, Xu Zhang, Sheng Wang*. Bifunctional Cascaded Single-Atom Nanozymes for Enhanced Photodynamic Immunotherapy through Dual-Depressing Pd-L1 and Regulating Hypoxia. Biomaterials 2025, 317, 123106.
- [12] Shutong Chen, Xinlu Zhang, Huan Li, Chen Cao, Xu Zhang, Jiansen Li, Shitian Jia, Yongxin Liu, Lei Han*, Sheng Wang*. Dual-Enzyme Inhibiting Nanomedicines for Enhanced Cancer Chemodynamic Therapy by Inducing Intratumoral Acidosis. Int. J. Pharm. 2024, 663, 124568.
- [13] Chen Cao, Qiangsheng Zhang, Yan Feng, Jiansen Li, Xiaoqun Gong*, Sheng Wang*. NQO1 and viscosity tandemly responsive NIR fluorescent probe for tumor imaging and monitoring tumor apoptosis. Sens. Actuators B: Chem. 2024, 418, 136247.
- [14] Huan Li, Xinlu Zhang, Shutong Chen, Chen Cao, Xu Zhang, Xue Li, Suixin Xing, Shitian Jia, Jiansen Li, Sheng Wang*. Hypoxia exacerbation-triggered doxorubicin prodrug activation for sequential photodynamic/chemotherapy. ACS Mater. Lett. 2024, 6, 2599-2608.
- [15] Xinlu Zhang, Xu Zhang, Shutong Chen, Yongxin Liu, Chen Cao, Guohui Cheng* Sheng Wang*. Glutathione-depleting polyprodrug nanoparticle for enhanced photodynamic therapy and cascaded locoregional chemotherapy. J. Colloid Interface Sci. 2024, 670, 279-287.
- [16] Guohui Cheng, Shuang Tao, Shuang Liu, Ping Wang, Chi Zhang, Jin Liu, Chuanchuan Hao, Sheng Wang*, Dong Guo*, Bo Xu*. Glutathione-Responsive Polymersome with Continuous Glutathione Depletion for Enhanced Photodynamic Therapy and Hypoxia-Activated Chemotherapy. ACS Macro Lett. 2024, 13, 599-606.
- [17] Shitian Jia, Xu Zhang, Haizhen Guo, Suixin Xing, Xinlu Zhang, Shutong Chen, Huan Li, Sheng Wang*. Reactive Oxygen Species-Activated Self-Accelerated Drug Release Nanoparticles for Enhanced Cancer Combination Therapy. ACS Appl. Nano Mater. 2024, 7, 10921-10927.
- [18] Jiansen Li#, Chen Cao#, Xinlu Zhang, Huan Li, Qin Fan, Shutong Chen, Xu Zhang, Sheng Wang*. Core-shell nanomedicine based on multifunctional tetrahedral DNA nanostructures for synergistic enhancement of tumor chemodynamic/chemo-immunotherapy. Chem. Eng. J. 2024, 490, 151728.
- [19] Jiansen Li, Chen Cao, Huan Li, Shutong Chen, Xiaoqun Gong*, Sheng Wang*. Highly Sensitive Quantitative Detection of Glutathione Based on a Fluorescence-Colorimetric Dual Signal Recognition Strategy. Sens. Actuators B: Chem. 2024, 409, 135597.
- [20] Chen Cao, Jun Zhou, Xinlu Zhang, Xu Zhang, Jiansen Li, Huan Li, Shutong Chen, Xiaoqun Gong*, Sheng Wang*. A red-emitting ultrasensitive fluorescent probe for specific detection and biological visualization of cysteine in vitro and in vivo. Spectrochim. Acta, Part A 2024, 305, 123429.
- [21] Chen Cao#, Jiansen Li#, Xinlu Zhang, Xu Zhang, Xiaoqun Gong*, Sheng Wang*. NQO1-Activated Multifunctional Theranostic Probe for Imaging-Guided Mitochondria-Targeted Photodynamic Therapy and Boosting Immunogenic Cell Death. Talanta 2024, 272, 125786.
- [22] Xu Zhang, Xinlu Zhang, Haizhen Guo, Shitian Jia, Yong Li, Suixin Xing, Jin Chang*, Sheng Wang*. A Photo-Activated Continuous Reactive Oxygen Species Nanoamplifier for Dual-Dynamic Cascade Cancer Therapy. Adv. Healthcare Mater. 2023, 2301469.
- [23] Xiaoen Shi, Haizhen Guo, Xinlu Zhang, Xu Zhang, Chen Cao, Huan Li, Shutong Chen, Lei Han*, Sheng Wang*. A Transformable Nanomedicine for Smart Cancer Therapy by Identifying the Environmental Characteristics. ACS Mater. Lett. 2023, 5, 2332-2338.
- [24] Jun Zhou, Chen Cao, Xinlu Zhang, Xu Zhang, Jiansen Li, Hongzhang Deng*, Sheng Wang*. Gas-assisted phototherapy for cancer treatment. J. Control. Release 2023, 360, 564-577.
- [25] Yating Zhang#, Shenghui Li#, Kirsten Loch#, Gregg A. Duncan, Logan Kaler, Rudra Pangeni, Weipan Peng, Sheng Wang∗, Xiaoqun Gong∗, Qingguo Xu*. pH-Responsive Mucus-Penetrating Nanoparticles for Enhanced Cellular Internalization by Local Administration in Vaginal Tissue. ACS Macro Lett. 2023, 12(4), 446-453.
- [26] Xu Zhang, Haizhen Guo, Xinlu Zhang, Xiaoen Shi, Peng Yu, Shitian Jia, Chen Cao, Sheng Wang*, Jin Chang*. Dual-Prodrug Cascade Activation for Chemo/Chemodynamic Mutually Beneficial Combination Cancer Therapy. Biomater. Sci. 2023, 11, 1066-1074.
- [27] X. Zhang, S. Wang*, G. Cheng, P. Yu, J. Chang*. Light-Responsive Nanomaterials for Cancer Therapy. Engineering 2022, 13, 18-30.
- [28] G. Cheng, D. Wu, S. Wang*, X. Zhang, P. Yu, J Chang*, X. Chen*. Stimuli-Responsive Size-Changeable Strategy for Cancer Theranostics. Nano Today 2021, 38, 101208.
- [29] G. Cheng, W. Zong, H. Guo, F. Li, X. Zhang, P. Yu, F. Ren, X. Zhang, X. Shi, F. Gao*, J. Chang*, S. Wang*. Programmed Size-Changeable Nanotheranostic Agents for Enhanced Imaging Guided Chemo/Photodynamic Combination Therapy and Fast Elimination. Adv. Mater. 2021, 33, 2100398.
- [30] P. Yu, X. Li, G. Cheng, X. Zhang, D. Wu*, J. Chang*, S. Wang*. Hydrogen Peroxide-Generating Nanomedicine for Enhanced Chemodynamic Therapy. Chin. Chem. Lett. 2021, 32, 2127-2138.
- [31] S. Wang, R. Tian*, X. Zhang, G. Cheng, P. Yu, J. Chang*, X. Chen*. Beyond Photo: Xdynamic Therapies in Fighting Cancer. Adv. Mater. 2021, 33, 2007488.
- [32] X. Zhang, S. Wang*, G. Cheng, P. Yu, J. Chang*, X. Chen*. Cascade Drug Release Strategy for Enhanced Anticancer Therapy. Matter 2021, 4, 26-53.
- [33] S. Wang, G. Yu, W. Yang, Z. Wang*, O. Jacobson, R. Tian, H. Deng, L. Lin*, X. Chen*. Photodynamic-Chemodynamic Cascade Reactions for Efficient Drug Delivery and Enhanced Combination Therapy. Adv. Sci. 2021, 8, 2002927.
- [34] D. Wu*, S. Wang*, G. Yu*, X. Chen*. Cell Death Mediated by the Pyroptosis Pathway with the Aid of Nanotechnology: Prospects for Cancer Therapy. Angew. Chem. Int. Ed. 2021, 60, 8018-8034.
- [35] H. Zhu, Q. Li, B. Shi, F. Ge, Y. Liu, Z. Mao, H. Zhu, S. Wang*, G. Yu*, F. Huang*, P. J Stang*. Dual-Emissive Platinum(II) Metallacage with a Sensitive Oxygen Response for Imaging of Hypoxia and Imaging-Guided Chemotherapy. Angew. Chem. Int. Ed. 2020, 59, 20208-20214.
- [36] L. Lin#, S. Wang#, H. Deng, W. Yang, L. Rao, R. Tian, Y. Liu, G. Yu, Z. Zhou, J. Song, H. Yang, Z. Chen*, X. Chen*. Endogenous Labile Iron Pool-Mediated Free Radical Generation for Cancer Chemodynamic Therapy. J. Am. Chem. Soc. 2020, 142, 15320-15330.
- [37] S. Wang*, F. Zhang, G. Yu, Z. Wang, O. Jacobson, Y. Ma, R. Tian, H. Deng, W. Yang, Z. Chen*, X. Chen*. Zwitterionic-to-Cationic Charge Conversion Polyprodrug Nanomedicine for Enhanced Drug Delivery. Theranostics 2020, 10, 6629-6637.
- [38] S. Wang, G. Yu, Z. Wang, O. Jacobson, L.S. Lin, W. Yang, H. Deng, Z. He, Y. Liu, Z. Chen*, X. Chen*. Enhanced Antitumor Efficacy by a Cascade of Reactive Oxygen Species Generation and Drug Release. Angew. Chem., Int. Ed. 2019, 58, 14758-14763.
- [39] L. Lin#, T. Huang#, J. Song, X. Ou, Z. Wang, H. Deng, R. Tian, Y. Liu, J. Wang, Y. Liu, G. Yu, Z. Zhou, S. Wang*, G. Niu, H. Yang, X. Chen*. Synthesis of Copper Peroxide Nanodots for H2O2 Self-Supplying Chemodynamic Therapy. J. Am. Chem. Soc. 2019, 141, 9937-9945.
- [40] S. Wang, Z. Wang, G. Yu, Z. Zhou, O. Jacobson, Y. Liu, Y. Ma, F, Zhang, Z. Chen*, X. Chen*. Tumor-Specific Drug Release and Reactive Oxygen Species Generation for Cancer Chemo/Chemodynamic Combination Therapy. Adv. Sci. 2019, 6, 1801986.
- [41] G. Yu#, T. Cen#, Z. He#, S.P. Wang, Z. Wang, X.W. Ying, S. Li*, O. Jacobson, S. Wang*, L. Wang, L. Lin, R. Tian, Z. Zhou, Q. Ni, X. Li, X. Chen*. Porphyrin Nanocage-Embedded Single Molecular Nanoparticles for Cancer Nanotheranostics. Angew. Chem., Int. Ed. 2019, 58, 8799-8803.
- [42] S. Wang, Z. Zhou, Z. Wang, Y. Liu, O. Jacobson, Z. Shen, X. Fu, Z.Y. Chen*, X. Chen*. Gadolinium Metallofullerene-Based Activatable Contrast Agent for Tumor Signal Amplification and Monitoring of Drug Release. Small 2019, 15, 1900691.
- [43] S. Wang, G. Yu*, Z. Wang, O. Jacobson, R. Tian, L.S. Lin, F. Zhang, J. Wang*, X. Chen*. Hierarchical Tumor Microenvironment- Responsive Nanomedicine for Programmed Delivery of Chemotherapeutics. Adv. Mater. 2018, 30, 1803926.
- [44] S. Wang, J. Lin*, Z. Wang, Z. Zhou, R. Bai, N. Lu, Y. Liu, X. Fu, O. Jacobson, W. Fan, J. Qu, S. Chen, T. Wang, P. Huang*, X. Chen*. Core-Satellite Polydopamine-Gadolinium Metallofullerene Nanotheranostics for Multimodal Imaging Guided Combination Cancer Therapy. Adv. Mater. 2017, 29, 1701013.
- [45] Y. Liu#, S. Wang#, Y. Ma, J. Lin, H.Y. Wang, Y. Gu*, X. Chen*, P. Huang*. Ratiometric Photoacoustic Molecular Imaging for Methylmercury Detection in Living Subjects. Adv. Mater. 2017, 29, 1606129.
- [46] S. Wang, P. Huang*, X. Chen*. Hierarchical Targeting Strategy for Enhanced Tumor Tissue Accumulation/Retention and Cellular Internalization. Adv. Mater. 2016, 28, 7340-7364.
- [47] S. Wang, P. Huang*, X. Chen*. Stimuli-Responsive Programmed Specific Targeting in Nanomedicine. ACS Nano 2016, 10, 2991-2994.
- [48] 3. S. Wang, P. Huang*, X. Chen*. Hierarchical Targeting Strategy for Enhanced Tumor Tissue Accumulation/Retention and Cellular Internalization. Adv. Mater. 2016, 28, 7340-7364.(高被引论文) 2. S. Wang, P. Huang*, X. Chen*. Stimuli-Responsive Programmed Specific Targeting in Nanomedicine. ACS Nano 2016, 10, 2991-2994. 1. S. Wang#, J. Lin#, T. Wang, X. Chen*, P. Huang*. Recent Advances in Photoacoustic Imaging for Deep-Tissue Biomedical Applications. Theranostics 2016, 6, 2394-2413.
- Honors & Awards
- [1] 2024年,天津大学教工示范岗标兵
- [2] 2024年,第十七届天津松正“挑战杯”天津大学大学生课外学术科技作品竞赛二等奖(指导教师)
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- [3] 2024年,第九届全国大学生生命科学竞赛(科学探究类)天津市二等奖(指导教师)
- [4] 2024年,第九届全国大学生生命科学竞赛(科学探究类)国家三等奖(指导教师)
- [5] 2023年,第八届全国大学生生命科学竞赛(科学探究类)天津市二等奖(指导教师)
- [6] 2023年,第八届全国大学生生命科学竞赛(科学探究类)国家三等奖(指导教师)
- [7] 2022年,天津大学第十五届“我心目中的十佳好导师”
- [8] 2022年,天津大学第十五届“挑战杯”学生课外学术作品竞赛特等奖(指导教师)
- [9] 2021年,天津大学研究生教育教学成果一等奖
- [10] 2021年,天津市青年科技工作者协会“优秀青年科技工作者”
- [11] 2021年,天津市第十六届“挑战杯”学生课外学术作品竞赛二等奖(指导教师)
- [12] 2021年,天津大学第十四届“挑战杯”学生课外学术作品竞赛特等奖(指导教师)
- [13] 2020, Young Elite Scientists Sponsorship Program by Tianjin