School of Life Sciences
Professor
纳米生物医学
shengwang@tju.edu.cn
Rm 110, Bldg. 14
300072
Sheng Wang received his Ph.D. in Materials Science from Tianjin University in 2015. He then worked as a postdoctoral researcher at National Institutes of Health (NIH). In 2019, he joined the faculty of Tianjin University as a Professor. His current research focuses on the design and development of stimuli-responsive nanomaterials for biomedical applications.
Researcher ID: ABE-4580-2020 https://publons.com/researcher/4038128/sheng-wang/;
ORCID: 0000-0002-4797-5310 http://orcid.org/0000-0002-4797-5310;
- Ph. D.| Tianjin University| Materials science| 2015
- Bachelor's Degree| Tianjin University| Materials science and engineering| 2010
- Biomaterials
- Cancer theranostics
- Nanomedicine
- BIO Integration Editorial Board Member
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2015.11-2019.9
 National Institutes of Health | Postdoctoral fellow  -
2019.11-Now
School of Life Sciences | Tianjin University | Professor 
- Papers
- [1] Shutong Chen, Xinlu Zhang, Huan Li, Chen Cao, Xu Zhang, Jiansen Li, Shitian Jia, Yongxin Liu, Lei Han*, Sheng Wang*. Dual-Enzyme Inhibiting Nanomedicines for Enhanced Cancer Chemodynamic Therapy by Inducing Intratumoral Acidosis. Int. J. Pharm. 2024, 663, 124568.
- [2] Chen Cao, Qiangsheng Zhang, Yan Feng, Jiansen Li, Xiaoqun Gong*, Sheng Wang*. NQO1 and viscosity tandemly responsive NIR fluorescent probe for tumor imaging and monitoring tumor apoptosis. Sens. Actuators B: Chem. 2024, 418, 136247.
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- [3] Huan Li, Xinlu Zhang, Shutong Chen, Chen Cao, Xu Zhang, Xue Li, Suixin Xing, Shitian Jia, Jiansen Li, Sheng Wang*. Hypoxia exacerbation-triggered doxorubicin prodrug activation for sequential photodynamic/chemotherapy. ACS Mater. Lett. 2024, 6, 2599-2608.
- [4] Xinlu Zhang, Xu Zhang, Shutong Chen, Yongxin Liu, Chen Cao, Guohui Cheng* Sheng Wang*. Glutathione-depleting polyprodrug nanoparticle for enhanced photodynamic therapy and cascaded locoregional chemotherapy. J. Colloid Interface Sci. 2024, 670, 279-287.
- [5] Guohui Cheng, Shuang Tao, Shuang Liu, Ping Wang, Chi Zhang, Jin Liu, Chuanchuan Hao, Sheng Wang*, Dong Guo*, Bo Xu*. Glutathione-Responsive Polymersome with Continuous Glutathione Depletion for Enhanced Photodynamic Therapy and Hypoxia-Activated Chemotherapy. ACS Macro Lett. 2024, 13, 599-606.
- [6] Shitian Jia, Xu Zhang, Haizhen Guo, Suixin Xing, Xinlu Zhang, Shutong Chen, Huan Li, Sheng Wang*. Reactive Oxygen Species-Activated Self-Accelerated Drug Release Nanoparticles for Enhanced Cancer Combination Therapy. ACS Appl. Nano Mater. 2024, 7, 10921-10927.
- [7] Jiansen Li#, Chen Cao#, Xinlu Zhang, Huan Li, Qin Fan, Shutong Chen, Xu Zhang, Sheng Wang*. Core-shell nanomedicine based on multifunctional tetrahedral DNA nanostructures for synergistic enhancement of tumor chemodynamic/chemo-immunotherapy. Chem. Eng. J. 2024, 490, 151728.
- [8] Jiansen Li, Chen Cao, Huan Li, Shutong Chen, Xiaoqun Gong*, Sheng Wang*. Highly Sensitive Quantitative Detection of Glutathione Based on a Fluorescence-Colorimetric Dual Signal Recognition Strategy. Sens. Actuators B: Chem. 2024, 409, 135597.
- [9] Chen Cao, Jun Zhou, Xinlu Zhang, Xu Zhang, Jiansen Li, Huan Li, Shutong Chen, Xiaoqun Gong*, Sheng Wang*. A red-emitting ultrasensitive fluorescent probe for specific detection and biological visualization of cysteine in vitro and in vivo. Spectrochim. Acta, Part A 2024, 305, 123429.
- [10] Chen Cao#, Jiansen Li#, Xinlu Zhang, Xu Zhang, Xiaoqun Gong*, Sheng Wang*. NQO1-Activated Multifunctional Theranostic Probe for Imaging-Guided Mitochondria-Targeted Photodynamic Therapy and Boosting Immunogenic Cell Death. Talanta 2024, 272, 125786.
- [11] Xu Zhang, Xinlu Zhang, Haizhen Guo, Shitian Jia, Yong Li, Suixin Xing, Jin Chang*, Sheng Wang*. A Photo-Activated Continuous Reactive Oxygen Species Nanoamplifier for Dual-Dynamic Cascade Cancer Therapy. Adv. Healthcare Mater. 2023, 2301469.
- [12] Xiaoen Shi, Haizhen Guo, Xinlu Zhang, Xu Zhang, Chen Cao, Huan Li, Shutong Chen, Lei Han*, Sheng Wang*. A Transformable Nanomedicine for Smart Cancer Therapy by Identifying the Environmental Characteristics. ACS Mater. Lett. 2023, 5, 2332-2338.
- [13] Jun Zhou, Chen Cao, Xinlu Zhang, Xu Zhang, Jiansen Li, Hongzhang Deng*, Sheng Wang*. Gas-assisted phototherapy for cancer treatment. J. Control. Release 2023, 360, 564-577.
- [14] Yating Zhang#, Shenghui Li#, Kirsten Loch#, Gregg A. Duncan, Logan Kaler, Rudra Pangeni, Weipan Peng, Sheng Wang∗, Xiaoqun Gong∗, Qingguo Xu*. pH-Responsive Mucus-Penetrating Nanoparticles for Enhanced Cellular Internalization by Local Administration in Vaginal Tissue. ACS Macro Lett. 2023, 12(4), 446-453.
- [15] Xu Zhang, Haizhen Guo, Xinlu Zhang, Xiaoen Shi, Peng Yu, Shitian Jia, Chen Cao, Sheng Wang*, Jin Chang*. Dual-Prodrug Cascade Activation for Chemo/Chemodynamic Mutually Beneficial Combination Cancer Therapy. Biomater. Sci. 2023, 11, 1066-1074.
- [16] X. Zhang, S. Wang*, G. Cheng, P. Yu, J. Chang*. Light-Responsive Nanomaterials for Cancer Therapy. Engineering 2022, 13, 18-30.
- [17] G. Cheng, D. Wu, S. Wang*, X. Zhang, P. Yu, J Chang*, X. Chen*. Stimuli-Responsive Size-Changeable Strategy for Cancer Theranostics. Nano Today 2021, 38, 101208.
- [18] G. Cheng, W. Zong, H. Guo, F. Li, X. Zhang, P. Yu, F. Ren, X. Zhang, X. Shi, F. Gao*, J. Chang*, S. Wang*. Programmed Size-Changeable Nanotheranostic Agents for Enhanced Imaging Guided Chemo/Photodynamic Combination Therapy and Fast Elimination. Adv. Mater. 2021, 33, 2100398.
- [19] P. Yu, X. Li, G. Cheng, X. Zhang, D. Wu*, J. Chang*, S. Wang*. Hydrogen Peroxide-Generating Nanomedicine for Enhanced Chemodynamic Therapy. Chin. Chem. Lett. 2021, 32, 2127-2138.
- [20] S. Wang, R. Tian*, X. Zhang, G. Cheng, P. Yu, J. Chang*, X. Chen*. Beyond Photo: Xdynamic Therapies in Fighting Cancer. Adv. Mater. 2021, 33, 2007488.
- [21] X. Zhang, S. Wang*, G. Cheng, P. Yu, J. Chang*, X. Chen*. Cascade Drug Release Strategy for Enhanced Anticancer Therapy. Matter 2021, 4, 26-53.
- [22] S. Wang, G. Yu, W. Yang, Z. Wang*, O. Jacobson, R. Tian, H. Deng, L. Lin*, X. Chen*. Photodynamic-Chemodynamic Cascade Reactions for Efficient Drug Delivery and Enhanced Combination Therapy. Adv. Sci. 2021, 8, 2002927.
- [23] D. Wu*, S. Wang*, G. Yu*, X. Chen*. Cell Death Mediated by the Pyroptosis Pathway with the Aid of Nanotechnology: Prospects for Cancer Therapy. Angew. Chem. Int. Ed. 2021, 60, 8018-8034.
- [24] H. Zhu, Q. Li, B. Shi, F. Ge, Y. Liu, Z. Mao, H. Zhu, S. Wang*, G. Yu*, F. Huang*, P. J Stang*. Dual-Emissive Platinum(II) Metallacage with a Sensitive Oxygen Response for Imaging of Hypoxia and Imaging-Guided Chemotherapy. Angew. Chem. Int. Ed. 2020, 59, 20208-20214.
- [25] L. Lin#, S. Wang#, H. Deng, W. Yang, L. Rao, R. Tian, Y. Liu, G. Yu, Z. Zhou, J. Song, H. Yang, Z. Chen*, X. Chen*. Endogenous Labile Iron Pool-Mediated Free Radical Generation for Cancer Chemodynamic Therapy. J. Am. Chem. Soc. 2020, 142, 15320-15330.
- [26] S. Wang*, F. Zhang, G. Yu, Z. Wang, O. Jacobson, Y. Ma, R. Tian, H. Deng, W. Yang, Z. Chen*, X. Chen*. Zwitterionic-to-Cationic Charge Conversion Polyprodrug Nanomedicine for Enhanced Drug Delivery. Theranostics 2020, 10, 6629-6637.
- [27] S. Wang, G. Yu, Z. Wang, O. Jacobson, L.S. Lin, W. Yang, H. Deng, Z. He, Y. Liu, Z. Chen*, X. Chen*. Enhanced Antitumor Efficacy by a Cascade of Reactive Oxygen Species Generation and Drug Release. Angew. Chem., Int. Ed. 2019, 58, 14758-14763.
- [28] L. Lin#, T. Huang#, J. Song, X. Ou, Z. Wang, H. Deng, R. Tian, Y. Liu, J. Wang, Y. Liu, G. Yu, Z. Zhou, S. Wang*, G. Niu, H. Yang, X. Chen*. Synthesis of Copper Peroxide Nanodots for H2O2 Self-Supplying Chemodynamic Therapy. J. Am. Chem. Soc. 2019, 141, 9937-9945.
- [29] S. Wang, Z. Wang, G. Yu, Z. Zhou, O. Jacobson, Y. Liu, Y. Ma, F, Zhang, Z. Chen*, X. Chen*. Tumor-Specific Drug Release and Reactive Oxygen Species Generation for Cancer Chemo/Chemodynamic Combination Therapy. Adv. Sci. 2019, 6, 1801986.
- [30] G. Yu#, T. Cen#, Z. He#, S.P. Wang, Z. Wang, X.W. Ying, S. Li*, O. Jacobson, S. Wang*, L. Wang, L. Lin, R. Tian, Z. Zhou, Q. Ni, X. Li, X. Chen*. Porphyrin Nanocage-Embedded Single Molecular Nanoparticles for Cancer Nanotheranostics. Angew. Chem., Int. Ed. 2019, 58, 8799-8803.
- [31] S. Wang, Z. Zhou, Z. Wang, Y. Liu, O. Jacobson, Z. Shen, X. Fu, Z.Y. Chen*, X. Chen*. Gadolinium Metallofullerene-Based Activatable Contrast Agent for Tumor Signal Amplification and Monitoring of Drug Release. Small 2019, 15, 1900691.
- [32] S. Wang, G. Yu*, Z. Wang, O. Jacobson, R. Tian, L.S. Lin, F. Zhang, J. Wang*, X. Chen*. Hierarchical Tumor Microenvironment- Responsive Nanomedicine for Programmed Delivery of Chemotherapeutics. Adv. Mater. 2018, 30, 1803926.
- [33] S. Wang, J. Lin*, Z. Wang, Z. Zhou, R. Bai, N. Lu, Y. Liu, X. Fu, O. Jacobson, W. Fan, J. Qu, S. Chen, T. Wang, P. Huang*, X. Chen*. Core-Satellite Polydopamine-Gadolinium Metallofullerene Nanotheranostics for Multimodal Imaging Guided Combination Cancer Therapy. Adv. Mater. 2017, 29, 1701013.
- [34] Y. Liu#, S. Wang#, Y. Ma, J. Lin, H.Y. Wang, Y. Gu*, X. Chen*, P. Huang*. Ratiometric Photoacoustic Molecular Imaging for Methylmercury Detection in Living Subjects. Adv. Mater. 2017, 29, 1606129.
- [35] S. Wang, P. Huang*, X. Chen*. Hierarchical Targeting Strategy for Enhanced Tumor Tissue Accumulation/Retention and Cellular Internalization. Adv. Mater. 2016, 28, 7340-7364.
- [36] S. Wang, P. Huang*, X. Chen*. Stimuli-Responsive Programmed Specific Targeting in Nanomedicine. ACS Nano 2016, 10, 2991-2994.
- [37] 3. S. Wang, P. Huang*, X. Chen*. Hierarchical Targeting Strategy for Enhanced Tumor Tissue Accumulation/Retention and Cellular Internalization. Adv. Mater. 2016, 28, 7340-7364.(高被引论文) 2. S. Wang, P. Huang*, X. Chen*. Stimuli-Responsive Programmed Specific Targeting in Nanomedicine. ACS Nano 2016, 10, 2991-2994. 1. S. Wang#, J. Lin#, T. Wang, X. Chen*, P. Huang*. Recent Advances in Photoacoustic Imaging for Deep-Tissue Biomedical Applications. Theranostics 2016, 6, 2394-2413.
- Honors & Awards
- [1] 2024年,第十七届天津松正“挑战杯”天津大学大学生课外学术科技作品竞赛二等奖(指导教师)
- [2] 2024年,第九届全国大学生生命科学竞赛(科学探究类)天津市二等奖(指导教师)
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- [3] 2024年,第九届全国大学生生命科学竞赛(科学探究类)国家三等奖(指导教师)
- [4] 2023年,第八届全国大学生生命科学竞赛(科学探究类)天津市二等奖(指导教师)
- [5] 2023年,第八届全国大学生生命科学竞赛(科学探究类)国家三等奖(指导教师)
- [6] 2022年,天津大学第十五届“我心目中的十佳好导师”
- [7] 2022年,天津大学第十五届“挑战杯”学生课外学术作品竞赛特等奖(指导教师)
- [8] 2021年,天津大学研究生教育教学成果一等奖
- [9] 2021年,天津市青年科技工作者协会“优秀青年科技工作者”
- [10] 2021年,天津市第十六届“挑战杯”学生课外学术作品竞赛二等奖(指导教师)
- [11] 2021年,天津大学第十四届“挑战杯”学生课外学术作品竞赛特等奖(指导教师)
- [12] 2020, Young Elite Scientists Sponsorship Program by Tianjin