• Papers

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• [1] A dual-receptor checkpoint primes enterovirus D68 for respiratory cell entry, Shengjian Liang, Haoran Guo, Zhili Xu, Zan Liu, Wanying Yang, Xiaoke Liu, Zhenyu Wei, Jichao Hou, Wei Huang, Wei Wang, Jiachen Li, Wendong Ma, Zhikang Deng, Haocong Qian, Yaxin Wang*, Jialin Liu*, Zihe Rao*, Wei Wei*, Zhiyong Lou*, Nature Communications, 2026.07.23
• [2] Structural and functional characterization of dsPETase05 for the degradation of Polyethylene terephthalate, Lurong Zhang, Xiaoyu Zhou, Yuxuan Yuan, Haoqing Li, Jiachen Li, Yibing Zhou, Siyu Du, Ziyu Wang, Yiting Han, Xinze Fan, Daiyi Han, Lijie Wang, Cheng Zhu, Sheng Ye*, Yaxin Wang*, Binghong Xu*, International Journal of Biological Macromolecules, 2026.01.16
• • [3] Structure-guided screening identifies Tucatinib as dual inhibitor for MCT1/2, Binghong Xu#*, Xiaoyu Zhou#, Yuanyue Shan#, Sai Shi#, Jiachen Li#, Qinqin Liang, Ziyu Wang, Mingfeng Zhang*, Yaxin Wang*, Duanqing Pei*, Sheng Ye*, EMBO reports, 2025,12,11
  • [4] A rationally designed cocktail of nanobodies elicited by heterologous vaccination confers protection against SFTSV in preclinical models, Xilin Wu*†, Linjing Zhu†, Shengjian Liang†, Zhen Chang†, Yaxin Wang†, Qingcui Zou†, Zhiyong Lou*, Minghua Li*, Yan Wu*, Zhiwei Wu*, Science Translational Medicine, 2025.11.19
  • [5] Structural and functional characterization of thermostable dUTPase P45 from Pyrococcus furiosus with enhanced PCR efficiency Bingjie Dong1¶*, Jiachen Li1¶, Lurong Zhang1¶, Bo Zhang2, Binghong Xu1,*, Sheng Ye1,*, Yaxin Wang1,*, International Journal of Biological Macromolecules, 2025.
  • [6] Bardoxolone methyl blocks the efflux of Zn2+ by targeting hZnT1 to inhibit the proliferation and metastasis of cervical cancer, Yaxin Wang#, Qinqin Liang#, Shengjian Liang#, Yuanyue Shan#, Sai Shi#, Xiaoyu Zhou, Ziyu Wang, Zhili Xu, Duanqing Pei, Mingfeng Zhang*, Zhiyong Lou*, Binghong Xu*, Sheng Ye*, Protein & Cell, 2025
  • [7] Transport mechanism and drug discovery of human monocarboxylate transporter 1 Sai Shi, Jia-chen Li, Xiao-yu Zhou, Zhen-lu Li, Ya-xin Wang*, Bing-hong Xu*, Sheng Ye*, Acta Pharmacologica Sinica volume 46, pages2323–2333 (2025).
  • [8] Etoposide targets 2A protease to inhibit enterovirus 71 replication Qinqin Liang #, Sai Shi #, Qingjie Zhang, Yaxin Wang*, Sheng Ye*, Binghong Xu*，Microbiology Spectrum, 2025.01
  • [9] Structural definition of pseudorabies virus dUTPase reveals a novel folding dimer in the herpesvirus family, Jiachen Li, Sen Ma, Runze Yang, Jinrui Xu, Yaxin Wang, Sheng Ye. International Journal of Biological Macromolecules, 2024. 09
  • [10] Sen Ma#, Doudou Zhang#, Qiwei Wang, Linjing Zhu, Xilin Wu*, Sheng Ye*, Yaxin Wang*.Structure defining of ultrapotent neutralizing nanobodies against MERS-CoV with novel epitopes on receptor binding domain. PLos Pathogens. 2024
  • [11] Linjing Zhu#, Bilian Huang#, Xiangyao Wang#, Sheng Ye, Yaxin Wang*, Yalan Liu*, Xilin Wu*. Ultrahigh-potent and broadly neutralizing anti-CD4 trimeric nanobodies inhibit HIV-1 infection by inducing CD4 conformational alteration. Nature Communications. 2024.
  • [12] Sen Ma#, Sai Shi#, Binghong Xu#, Meijun Liu, Lei Xie, Yang Su, Jiachen Li, Qinqin Liang, Sheng Ye1*, Yaxin Wang*, Host serine protease ACOT2 assists DENV proliferation by hydrolyzing viral polyproteins, msystems, 2023,12
  • [13] Qingdian Yin#, Jiaxing Zhang#, Sen Ma#, Tao Gu, Mengfan Wang, Shengping You*, Sheng Ye*, Rongxin Su, Yaxin Wang *, Wei Qi*, Efficient polyethylene terephthalate biodegradation by an engineered Ideonella sakaiensis PETase with a fixed substrate binding W156 residue, Efficient polyethylene terephthalate biodegradation by an engineered Ideonella sakaiensis PETase with a fixed substrate binding W156 residue, Green Chemistry, 2023, 11
  • [14] Lei Xie#, Sai Shi#, Lin Cheng, Binghong, Sen Ma, Jie Liu, Xilin Wu*,Yaxin Wang*, Sheng Ye*,Dauricine interferes with SARS-CoV-2 variants infection by blocking the interface between RBD and ACE2,International Journal of Biological Macromolecules,2023,10
  • [15] Shi Sai#, Xie Lei#, Ma Sen, Xu Binghong, An Hailong, Ye Sheng*, Wang Yaxin*, Computational and experimental studies of salvianolic acid A targets 3C protease to inhibit enterovirus 71 infection, Front. Pharmacol., 02 March 2023.
  • [16] Wang Yaxin#; Xu Binghong#; Ma Sen; Wang Hao; Shang Luqing; Zhu Cheng*; Ye Sheng*;Discovery of SARS-CoV-2 3CLPro Peptidomimetic Inhibitors through the Catalytic Dyad Histidine-Specific Prot ein–Ligand Interactions, International Journal of Molecular Sciences, 2022, 23
  • [17] Wu Xilin#; Wang Yaxin#; Cheng Lin#; Ni Fengfeng#; Zhu Linjing; Ma Sen; Huang bilian; Ji Mengmeng; Hu Huimin; Li Yuncheng; Xu Shijie; Shi Haixia; Zhang Dongdong; Liu Linshuo; Waqas Nawaz; HuQinxue; Ye Sheng*; Liu Yalan*; Wu Zhiwei*; Short-term instantaneous prophylaxis and efficient treatment against SARS-CoV-2 in hACE2 mice conferred by an intranasal nanobody (Nb22), Frontiers in Immunology, 2022
  • [18] Liu, Meijun#; Xu, Binghong; Ma, Yuying; Shang, Luqing*; Ye, Sheng*; Wang, Yaxin*; Reversible covalent inhibitors suppress enterovirus 71 infection by targeting the 3C protease, Antiviral Research, 2021, 192: 0-105102
  • [19] Binghong Xu#; Meijun Liu; Sen Ma; Yuying Ma; Si Liu; Luqing Shang; Cheng Zhu*; Sheng Ye*; Wangyaxin*; 4-Iminooxazolidin-2-One as a Bioisostere of Cyanohydrin Suppresses EV71 Proliferation by Targeting 3Cpro, Microbiology Spectrum, 2021, 9(3)
  • [20] Ma, Yuying#; Li, Linfeng; He, Shuai; Shang, Chengyou; Sun, Yang; Liu, Ning; Meek, Thomas D*; Wang, Yaxin*; Shang, Luqing*; Application of Dually Activated Michael Acceptor to the Rational Design of Reversible Covalent Inhibitor for Enterovirus 71 3C Protease, Journal of Medicinal Chemistry, 2019, 62(13): 6146-6162
  • [21] Wang Yaxin#, Liu Jingwei#, Cao Lin, Wang Wenjing, Sun Yuna, Yin Zheng, Lou Zhiyong*, Site-specific Incorporation of Chemical Fluorescence on Live Enterovirus-71 Virion by Organometallic Palladium Reagent to Monitor Virus Entry, Chembiochem. 2018,7,16;19(14):1465-1470
  • [22] Wang Yaxin#, Cao Lin, Zhai Yangyang, Yin Zheng, Sun Yuna, Shang Luqing*, Structure of the Enterovirus 71 3C Protease in Complex with NK-1.8k and Indications for the Development of Antienterovirus Protease, Antimicrob Agents Chemother, 2017,6,27;61(7):e00298-17.
  • [23] Wang Yaxin#, Cao Lin#, Zhai Yangyang, Ma Jiaming, Nie Quandeng, Li Ting, Yin Zheng, Sun Yuna*, Luqing Shang*, Inhibition of enterovirus 71 replication by an α-hydroxy-nitrile derivative NK-1.9k, Antiviral Res, 2017.5,141: 91-100
  • [24] Guo Yu#, Wang Yaxin#, Cao Lin, Wang Peng, Qing Jie, Zheng Qizhen, Shang Luqing, Yin Zheng*, Sun Yuna*, A conserved inhibitory mechanism of a lycorine derivative against enterovirus and hepatitis C virus, Antimicrob Agents Chemother, 2015,11,23;60(2):913-24.
  • [25] Wang Yaxin#, Yang Ben#, Zhai Yangyang, Yin Zheng*, Sun Yuna*, Rao Zihe, Peptidyl aldehyde NK-1.8k suppresses enterovirus 71 and enterovirus 68 infection by targeting protease 3C, Antimicrob Agents Chemother, 2015 5;59(5):2636-46.
  • [26] Shang Luqing#, Wang Yaxin#, Qing Jie, Shu Bo, Cao Lin, Lou Zhiyong, Gong Peng, Sun Yuna*, Yin Zheng*, An adenosine nucleoside analogue NITD008 inhibits EV71 proliferation, Antiviral Res, 2014,12;112:47-58.
  • [27] Qing Jie#, Wang Yaxin#, Sun Yuna#, Huang Jiaoyan, Yan Wenzhong, Wang Jinglan, Su Dan, Ni Cheng, Li Jian, Rao Zihe, Liu Lei*, Lou Zhiyong*, Cyclophilin A associates with enterovirus-71 virus capsid and plays an essential role in viral infection as an uncoating regulator, PLoS Pathog, 2014,10,2;10(10):e1004422
  • [28] Wang Yaxin#, Qing Jie#, Sun Yuna*, Rao Zihe*, Suramin inhibits EV71 infection, Antiviral Res, 2014,3;103:1-6.
  • [29] Chen Cheng#, Wang Yaxin#, Shan Chao#, Sun Yuna, Xu Peng, Zhou Honggang, Yang Cheng, Shi Pei-Yong, Rao Zihe, Zhang Bo*, Lou Zhiyong*, Crystal Structure of Enterovirus 71 RNA-Dependent RNA Polymerase Complexed with Its Protein Primer VPg: Implication for a trans Mechanism of VPg Uridylylation, J Virol, 2013,5;87(10):5755-68.
  • [30] Sun Yuna#, Wang Yaxin#, Shan Chao#, Chen Cheng, Xu Peng, Song Mohan, Zhou Honggang, Yang Cheng, Xu Wenbo, Shi Pei-Yong, Zhang Bo*, Lou Zhiyong*, Enterovirus 71 VPg uridylation uses a two-molecular mechanism of 3D polymerase, J Virol. 2012 12;86(24):13662-71.
  • [31] Zhai Yangyang#, Ma Yuying, Ma Fei, Nie Quandeng, Ren Xuejiao, Wang Yaxin, Shang Luqing*, Yin Zheng*, Structure-activity relationship study of peptidomimetic aldehydes as enterovirus 71 3C protease inhibitors, Eur J Med Chem. 2016 11 29;124:559-573.
  • [32] Han Zhiqiang#, Liang Xiao, Wang Yaxin, Qing Jie, Cao Lin, Shang Luqing*, Yin Zheng*, The discovery of indole derivatives as novel hepatitis C virus inhibitors, Eur J Med Chem. 2016 6 30;116:147-155
  • [33] Zeng Debin#, Ma Yuying, Zhang Rui, Nie Quandeng, Cui Zhengjie, Wang Yaxin, Shang Luqing*, Yin Zheng*, Synthesis and structure-activity relationship of α-keto amides as enterovirus 71 3C protease inhibitors, Bioorg Med Chem Lett. 2016 4 1;26(7):1762-6.
  • [34] Qing Jie#*, Luo Rui, Wang Yaxin, Nong Junxiu, Wu Ming, Shao Yan, Tang Ruoyi, Yu Xi, Yin Zheng, Sun Yuna*, Resistance analysis and characterization of NITD008 as an adenosine analog inhibitor against hepatitis C virus, Antiviral Res. 2016 2;126:43-54.
  • [35] Zhai Yangyang#, Zhao Xiangshuai, Cui Zhengjie, Wang Man, Wang Yaxin, Li Linfeng, Sun Qi, Yang Xi, Zeng Debin, Liu Ying, Sun Yuna, Lou Zhiyong, Shang Luqing*, Yin Zheng*, Cyanohydrin as an Anchoring Group for Potent and Selective Inhibitors of Enterovirus 71 3C Protease, J Med Chem. 2015 12 10;58(23):9414-20.
  • [36] Dang Minghao#, Wang Xiangxi, Wang Quan, Wang Yaxin, Lin Jianping, Sun Yuna, Li Xuemei, Zhang Liguo, Lou Zhiyong, Wang Junzhi, Rao Zihe*, Molecular mechanism of SCARB2-mediated attachment and uncoating of EV71, Protein Cell. 2014 9;5(9):692-703.

• Books
• [1] Some RNA Viruses, The causative agent of FMD disease

• Honors & Awards

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• [1] 2026年天津大学杰出师友导师
• [2] 2025年天津大学优秀硕士论文指导教师
• • [3] Outstanding Mentor of Tianjin University 2025
  • [4] Outstanding Mentor of Tianjin University 2024
  • [5] Young backbone Teacher of Beiyang University