Chen Cheng
School
School of Life Sciences
Professional Title
Associate professor
Administrative Appointments
无
Discipline
结构病毒学；罕见病
Contact Information
022-27403906
022-27403902
chengchen@tju.edu.cn
School of Life Sciences, Building 15, Tianjin University; No.92 Weijin Road, Nankai District, Tianjin 300072, China
300072
Education Background
- Doctoral degree| Tsinghua University| Biology| 2013
- Bachelor’s Degree| Nanjin University| Biophysics| 2006
Research Interests
- The pathologic mechanism underlying hereditary rare diseases, e.g., intellectual disability syndrome, progressive symmetric erythrokeratoderma disorders, etc.
- The dynamic regulation mechanism underlying the pahogenesis particularly the replication event of significant or model viruses including SARS-CoV-2, MERS-CoV, EV71, etc.
Positions & Employments
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2018.8-Now
School of Life Sciences | Tianjin University | Associate professor -
2016.2-2016.7
Division of Structural Biology, Nuffield Department of Clinical Medicine | Oxford University | Visiting Scholar -
2013.7-2018.7
School of Life Sciences | Tianjin University | Lecturer
Academic Achievements
- Papers
- [1] Cheng Chen#, Yaxin Wang#, Chao Shan#, Yuna Sun, Peng Xu, Honggang Zhou, Cheng Yang, Pei-Yong Shi, Zihe Rao, Bo Zhang*, and Zhiyong Lou*, Crystal structure of enterovirus 71 RNA-dependent RNA polymerase complexed with its protein primer VPg: implication for a trans mechanism of VPg uridylylation, Journal of Virology, 2013, 87(10): 5755-5768. (IF: 4.519)
- [2] Dan Fu#, Dongming Zhao#, Wei Zhang#, Guangshun Zhang, Mingyu Li, Zheng Zhang, Yuhui Wang, Dongdong Sun, Peng Jiao, Cheng Chen*, Yu Guo*, and Zihe Rao, Structure of African swine fever virus p15 reveals its dual role for membrane-association and DNA binding, Protein Cell, 2020, 11(8): 606-612. (IF: 10.164)
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- [3] Wen Cui#, Shanshan Cui#, Cheng Chen#, Xia Chen, Zefang Wang*, Haitao Yang, and Lei Zhang*, The crystal structure of main protease from mouse hepatitis virus A59 in complex with an inhibitor, Biochem Biophys Res Commun, 2019, 511(4): 794-799. (IF: 2.705)
- [4] Xiaoyun Yang#, Cheng Chen#, Hongliang Tian#, Heng Chi, Zhongyu Mu, Tianqing Zhang, Kailin Yang, Qi Zhao, Xiaohua Liu, Zefang Wang*, Xiaoyun Ji, Haitao Yang*, Mechanism of ATP hydrolysis by the Zika virus helicase, FASEB Journal, 2018: fj201701140R. (IF: 5.391)
- [5] Li Wang#, Bo-Bo Bao#, Guo-Qing Song, Cheng Chen*, Xu-Meng Zhang, Wei Lu, Zefang Wang, Yan Cai, Shuang Li, Sheng Fu, Fu-Hang Song, Haitao Yang, and Jian-Guo Wang*, Discovery of unsymmetrical aromatic disulfides as novel inhibitors of SARS-CoV main protease: Chemical synthesis, biological evaluation, molecular docking and 3D-QSAR study, European Journal of Medicinal Chemistry, 2017. 137: 450-461. (IF: 4.816)
- [6] Tingting Hu#, Cheng Chen#, Huiyan Li, Yanshu Dou, Ming Zhou, Deren Lu, Qi Zong, Yulei Li, Cheng Yang, Zhihui Zhong, Namit Singh, Honggang Hu, Rundong Zhang, Haitao Yang*, and Dan Su*, Structural basis for dimerization and RNA binding of avian infectious bronchitis virus nsp9, Protein Science, 2017. 26(5): 1037-1048. (IF: 2.41)
- [7] Fenghua Wang#, Cheng Chen#, Kailin Yang#, Yang Xu, Xiaowei Liu, Fan Gao, He Liu, Xia Chen, Qi Zhao, Xiang Liu, Yan Cai*, and Haitao Yang*, Michael Acceptor-Based Peptidomimetic Inhibitor of Main Protease from Porcine Epidemic Diarrhea Virus, Journal of Medicinal Chemistry, 2017. 60(7): 3212-3216. (IF: 6.253)
- [8] Deping Wang#, Cheng Chen#, Shengnan Liu#, Han Zhou#, Kailin Yang, Qi Zhao, Xiaoyun Ji, Chen CHEN, Wei Xie, Zefang Wang, Li-Zhi Mi*, and Haitao Yang*, A Mutation Identified in Neonatal Microcephaly Destabilizes Zika Virus NS1 Assembly in Vitro, Scientific Reports, 2017. 7: 42580. (IF: 4.122)
- [9] Fenghua Wang#, Cheng Chen#, Wenjie Tan, Kailin Yang*, and Haitao Yang*, Structure of Main Protease from Human Coronavirus NL63: Insights for Wide Spectrum Anti-Coronavirus Drug Design, Scientific Reports, 2016, 6:22677. (IF: 4.259)
- [10] Haofeng Wang#, Song Xue, Haitao Yang*, and Cheng Chen*, Recent progress in the discovery of inhibitors targeting coronavirus proteases, Virologica Sinica, 2016, 31(1): 24-30. (IF: 2.415)
- [11] Fenghua Wang#, Cheng Chen#, Xuemeng Liu, Kailin Yang, Xiaoling Xu*, and Haitao Yang*, Crystal Structure of Feline Infectious Peritonitis Virus Main Protease in Complex with Synergetic Dual Inhibitors, Journal of Virology, 2015, 90(4): 1910-1917. (IF: 4.606)
- [12] Ting Li#, Qi Zhao#, Xiaoyun Yang#, Cheng Chen, Kailin Yang, Chen Wu, Tianqing Zhang, Yingkai Duan, Xiaoyu Xue, Kaixia Mi, Xiaoyun Ji, Zefang Wang, Haitao Yang*, Structural insight into the Zika virus capsid encapsulating the viral genome, Cell Research, 2018, 28(4): 497-499. (IF: 15.606)
- [13] Han Zhou#, Fenghua Wang#, Haofeng Wang#, Cheng Chen, Tianqing Zhang, Xu Han, Deping Wang, Chen Chen, Chen Wu, Wei Xie, Zefang Wang, Lei Zhang, Lanfeng Wang*, Haitao Yang*, The conformational changes of Zika virus methyltransferase upon converting SAM to SAH, Oncotarget, 2017, 8(9): 14830-14834. (IF: 5.168)
- [14] Xia Chen#, Kailin Yang#, Chen Wu#, Cheng Chen, Can Hu, Olga Buzovetsky, Zefang Wang, Xiaoyun Ji*, Yong Xiong, and Haitao Yang*, Mechanisms of activation and inhibition of Zika virus NS2B-NS3 protease, Cell Research, 2016, 26(11): 1260-1263. (IF: 15.606)
- [15] Hongliang Tian#, Xiaoyun Ji#, Xiaoyun Yang#, Wei Xie, Kailin Yang, Cheng Chen, Chen Wu, Heng Chi, Zhongyu Mu, Zewang Wang, and Haitao Yang*, The crystal structure of Zika virus helicase: basis for antiviral drug design, Protein Cell, 2016, 7(6): 450-454. (IF: 5.374)
- [16] Hongliang Tian#, Xiaoyun Ji#, Xiaoyun Yang#, Zhongxin Zhang#, Zuokun Lu, Kailin Yang, Cheng Chen, Qi Zhao, Heng Chi, Zhongyu Mu, Wei Xie, Zefang Wang, Huiqiang Lou, Haitao Yang*, and Zihe Rao, Structural basis of Zika virus helicase in recognizing its substrates, Protein Cell, 2016, 7(8): 562-570. (IF: 5.374)
- [17] Jinshan Wang#, Fenghua Wang#, Yusheng Tan, Xia Chen, Qi Zhao, Sheng Fu, Shuang Li*, Cheng Chen*, Haitao Yang, Crystallization and preliminary crystallographic study of Feline infectious peritonitis virus main protease in complex with an inhibitor, Acta Crystallogr F Struct Biol Commun, 2014, 70(12): 1612-1615. (IF: 0.524)
- [18] Yusheng Tan#, Fenghua Wang#, Xia Chen, Jinshan Wang, Qi Zhao, Shuang Li, Zefang Wang, Sheng Fu*, Cheng Chen*, Haitao Yang, Crystallization and preliminary crystallographic study of Porcine epidemic diarrhea virus main protease in complex with an inhibitor, Acta Crystallogr F Struct Biol Commun, 2014, 70(12): 1608-1611. (IF: 0.524)
- [19] Xia Chen#, Yusheng Tan#, Fenghua Wang, Jinshan Wang, Qi Zhao, Shuang Li, Sheng Fu*, Cheng Chen*, and Haitao Yang, Expression, crystallization and preliminary crystallographic study of the functional mutant (N60K) of nonstructural protein 9 from Human coronavirus HKU1, Acta Crystallogr F Struct Biol Commun, 2014, 70(12): 1620-1623. (IF: 0.524)
- [20] Fenghua Wang#, Yusheng Tan#, Huiyan Li, Xia Chen, Jinshan Wang, Shuang Li, Sheng Fu, Qi Zhao, Cheng Chen*, Dan Su*, Haitao Yang, Crystallization and preliminary crystallographic study of human coronavirus NL63 main protease in complex with an inhibitor, Acta Crystallogr F Struct Biol Commun, 2014, 70(8): 1068-1071. (IF: 0.524)
- [21] Yuna Sun#, Yaxin Wang#, Chao Shan#, Cheng Chen, Peng Xu, Mohan Song, Honggang Zhou, Cheng Yang, Wenbo Xu, Pei-Yong Shi, Bo Zhang*, and Zhiyong Lou*, Enterovirus 71 VPg uridylation uses a two-molecular mechanism of 3D polymerase, Journal of Virology, 2012, 86(24): 13662-13671. (IF: 4.519)
- [22] Wei Wang, Lei Wei, Anqi Yang, Teng He, KY Yuen, Cheng Chen*, and Rao Z, Expression, crystallization and preliminary crystallographic study of human coronavirus HKU1 nonstructural protein 9, Acta Crystallogr F Struct Biol Commun, 2009, 65(5): 526-528. (IF: 0.524)