School of Chemical Engineering and Technology
Professor
Biochemical Engineering
18622532596
chentao@tju.edu.cn
Room256, Building54, Yaguan Road 135#,Jinnan District
Dr. Chen received his PhD degree from School of Chemical Engineering & Technology, Tianjin University in 2004, then worked as a postdoctoral fellow at Tianjin University from 2004 to 2006. He joined Tianjin University as an associate professor in 2007 and his research interests focus on the area of metabolic engineering and synthetic biology, mainly including: (i) Genome scale metabolic network construction and in silicon analysis for pathway optimization. (ii) Metabolic engineering of microbe for production of platform chemicals. (iii)The development of genome editing tools and genome reduced bacteria.
He has published more than 70 SCI papers (ResearcherID: N-1817-2015; ORCID ID: 0000-0001-9588-1821) which have been cited more than 1300 times in web of science and nearly 2000 times in google scholar (H-index of 20 in web of science and 25 in google scholar). He also has co-authored three books since 2008, and got 8 projects supported by the government and two projects supported by companies.
- Doctoral Degree| Tianjin University| Biochemical Engineering| 2006
- Master Degree| Tianjin University of Science &Technology| Fermentation Engineering| 2000
- Bachelor Degree| Hubei University of Technology| Fermentation Engineering| 1996
- The development of genome editing tools and genome reduced bacteria.
- Metabolic engineering of microbe for production of platform chemicals.
- Genome scale metabolic network construction and in silicon analysis for pathway optimization
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2007.1-2019.12
 Tianjin University | Associate Professor  -
2004.9-2006.12
 Tianjin University | Post Doctorate 
- Papers
- [1] .Tao Chen*; Weixi Liu; Jing Fu; Bo Zhang; Ya-jie Tang, Engineering Bacillus subtilis for acetoin production from glucose and xylose mixtures, Journal of Biotechnology, 2013,168(4):499-505.
- [2] Zheng, Zongbao; Chen, Tao*; Zhao, Meina; Wang, Zhiwen; Zhao, Xueming, Engineering Escherichia coli for succinate production from hemicellulose via consolidated bioprocessing, Microbial Cell Factories, 11(3):37,2012.
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- [3] Li, Yifan; Gu, Qun; Lin, Zhenquan; Wang, Zhiwen; Chen, Tao*; Zhao, Xueming, Multiplex Iterative Plasnnid Engineering for Combinatorial Optimization of Metabolic Pathways and Diversification of Protein Coding Sequences, ACS Synthetic Biology, 2(11):2013, 651-661.
- [4] Fu, Jing; Wang, Zhiwen; Chen, Tao*; Liu, Weixi; Shi, Ting; Wang, Guanglu; Tang, Ya-jie; Zhao, Xueming, NADH plays the vital role for chiral pure D-(-)-2,3-butanediol production in Bacillus subtilis under limited oxygen conditions., Biotechnology and Bioengineering, 2014,111: 2126-2131.
- [5] Ning Li; Bo Zhang; Zhiwen Wang; Ya-Jie Tang; Tao Chen*; Xueming Zhao, Engineering Escherichia coli for fumaric acid production from glycerol., Bioresour Technol, 2014,174C: 81-87.
- [6] Yan Zhang,Zhenquan Lin,Qiaojie Liu,Yifan Li,Zhiwen Wang,Hongwu Ma,Tao Chen*,Xueming Zhao. Engineering of Serine-Deamination pathway, Entner-Doudoroff pathway and pyruvate dehydrogenase complex to improve poly(3-hydroxybutyrate) production in Escherichia coli. Microbial Cell Factories.2014, 13(1):172.
- [7] Zhang, Bo;Li, Ning;Wang, Zhiwen; ang, Ya-Jie; Chen, Tao*; Zhao, Xueming, Inverse metabolic engineering of Bacillus subtilis for xylose utilization based on adaptive evolution and whole-genome sequencing, Applied Microbiology and Biotechnology, 99(2), 2015: 885-896.
- [8] Yifan Li; Zhenquan Lin; Can Huang; Yan Zhang; Zhiwen Wang; Chen Tao*, Xueming Zhao. Metabolic engineering of Escherichia coli using CRISPR-Cas9 meditated genome editing. Metabolic Engineering. 2015. 31: 13-21.
- [9] Y Li, X Zhu, X Zhang, J Fu, Z Wang, T Chen*, X Zhao. Characterization of genome-reduced Bacillus subtilis strains and their application for the production of guanosine and thymidine. Microbial cell factories. 2016.15:94.
- [10] J Fu, G Huo, L Feng, Y Mao, Z Wang*, H Ma, T Chen*, X Zhao. Metabolic engineering of Bacillus subtilis for chiral pure meso-2, 3-butanediol production. Biotechnology for biofuels. 2016.9:90.
- [11] G Huo, Y Zhu, Q Liu, R Tao, N Diao, Z Wang, T Chen*. Metabolic engineering of an E. coli ndh knockout strain for PHB production from mixed glucose‐xylose feedstock.Journal of Chemical Technology and Biotechnology.2017, 92(10):2739-2745.
- Books
- [1] Edited by Hal S. Alper; Systems Metabolic Engineering:Methods and Protocols; Humana Press; 978-1-62703-298-8; 2013.07 (Chapter 22 was written by Suobo Shi, Tao Chen and Xueming Zhao)
- [2] Translated by Tao CHEN, Xueming ZHAO et al. Bioprocess Engineering: basic concepts.; Chemical Industry Press; 2008.04
- Patents
- [1] The construction and application of an E.coli recombinant strain for riboflavin production.
- [2] The construction and application of an E.coli recombinant strain for succinic acid production from glycerol.
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- [3] A recombinant Bacillus subtilis that can grow on xylose with rapid growth rate
- [4] The construction and application of an E.coli recombinant strain for poly(3-hydroxybutyrate) production
- [5] 1. The construction and application of a Bacillus subtilis strain for high purity D(-)--2,3-butanediol production
- [6] The construction and application of a Bacillus subtilis strain for high purity meso-2,3-butanediol production