Li Youxin
School
School of Pharmaceutical Science and Technology, Medical College
Professional Title
Associate professor
Discipline
Pharmaceutical Analysis
Contact Information
lyx@tju.edu.cn
Room 412-8, Building 24, Tianjin University
Brief Introduction
Youxin Li, Associate Professor, PhD Supervisor. She has long been engaged in the teaching and scientific research of pharmaceutical analysis. In teaching, he has presided over 10 teaching reform projects, participated in the construction of Tianjin first-class undergraduate course Pharmaceutical Analysis and university-level curriculum ideological and political projects. She has supervised 9 college students' innovation and entrepreneurship training programs. She was awarded the title of Excellent Mentor of Tianjin University in 2024 and nominated for the Distinguished Mentor Award of Tianjin University in 2025. Her research focuses on sample pretreatment methods, chromatographic separation and purification media, chiral analysis, enzyme analysis and other fields. To date, she has published 100 high-level scientific papers, obtained 9 invention patents, contributed one book chapter, and presided over or participated in more than 30 horizontal and vertical research projects at national, provincial and ministerial levels. She serves as a peer reviewer for over 30 internationally renowned journals, Youth Editorial Board Member of Chinese Journal of Chromatography, Journal of Analysis and Testing and Journal of Instrumental Analysis, Guest Editor of Separations, and Editor of Chinese Journal of Analysis Laboratory.
Education Background
- Doctoral degree| Tianjin University| Applied Chemistry| 2010
- Master’s Degree| Tianjin Medical University| Pharmaceutical Analysis| 2007
Research Interests
- Li’s research addresses development of new techniques (such as HPLC, CE), chiral analysis, enzyme analysis, sample preparation, separation and purification of complex samples and their activities, and high throughput drug screening, and their applications.
Professional Membership
- 《Frontiers in Microbiology》Guess editor
- Journal of Instrumental Analysis, Youth Editorial Board Member
- Journal of Analysis and Testing, Youth Editorial Board Member
- Chinese Journal of Analysis Laboratory，Youth Editorial Board Member，editor
- Chinese Journal of Chromatography, Youth Editorial Board Member
- Coressponding reviewer for over 30 international journals, including“ACS Applied Nano Materials”、“Molecular Pharmaceutics”、“Analytica Chimica Acta”、“International Journal of Food Science and Technology”、“Small”、“Colloid and Polymer Science”, etc.
Positions & Employments
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2017.11-2018.11
Purdue University | Visting scholar -
2014.6-2014.11
Miami University | Visting scholar -
2016.6-Now
School of Pharmaceutical Science and Technology | Tianjin University | Associate Professor -
2010.10-2016.6
School of Pharmaceutical Science and Technology | Tianjin University. | Lecturer
Academic Achievements
- Papers
- [1] Guirong Borijihan, Mimi Liu*, Mingming Bao, Fuquan Li, Youxin Li*, Meng He*, Ethylene glycol monopiperate: Synthesis, anti-hyperlipidemic activity, and pharmacokinetic study, Journal of Analytical Methods in Chemistry, 2026, In press.
- [2] Xinyu Xu, Guirong Borijihan, Mengqi Cheng, Yanmei Xu, Xiao Zhang, Xinru Wang, Yuchen Cui, Youxin Li*, Surface molecularly imprinted magnetic nanoparticles for selective enrichment of betamethasone in environmental and biological matrices, Journal of Analysis and Testing, 2026, In press.
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- [3] Mengqi Cheng, Wanting Duan, Jiajia Fu, Ziyi Cheng, Xinru Wang, Ruijun Tang, Yanmen Xu, Yuchen Cui, and Youxin Li, Enhancing antioxidant activities of Orthosiphon aristatus extract via selective separation of rosmarinic acid and its analogues using multi-monomers rosmarinic acid-molecularly imprinted nanoparticles, Microchemical Journal, 2026, 228:119062.
- [4] Mengqi Cheng, Guirong Borijihan, Ruijun Tang, Xinru Wang, Yuchen Cui, Yanmei Xu, Ziyi Cheng, Jiajia Fu, Wanting Duan, Yunfei Du, Youxin Li*, Highly efficient and selective magnetic molecularly imprinted nanoparticles through multi-interactions for quercetin separation from complex matrices and antioxidant activity evaluation, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2026, 749:141326.
- [5] Xiaoqian Yuan†, Ziyi Cheng†, Jiajia Fu, Wanting Duan, Yuchen Cui, Ruijun Tang, Xinru wang, Youxin Li*, A synergy strategy of deep eutectic solvents and boric acid modified β-CD polymer for enhancing enantioseparation in HPLC, Analytica Chimica Acta, 2026, 1418:345876.
- [6] Wen Zhang, Yunuo Ren, Xiaoxi Liu, Xingmiao Liu, Weiwei Tang, Yingjie Ju, Wei Yu, Zhimou Guo, Huanhuan Qiao, Xiaoli Yu, Suxia Ren, Tianxiang Li, Yuqing Dong, Zengyi Huang, Youxin Li*, Zhiguang Yuchi*, Dong Li*, Yiwen Wang*, The medicine-food homology fruit Gouqi (Lycium barbarum L.) mitigates kidney stone via multiple bioactivities, Natural Product Communications, 2026, 21(5):1934578X261451343.
- [7] Ruijun Tang†, Ran Zhao†, Yuchen Cui, Xinru Wang, Yanmei Xu, Yiwen Wang*, and Youxin Li*, Efficient magnetic molecularly imprinted nanoparticle strategy for rapid lactic acid separation from fermentation broth, Microchemical Journal, 2026, 221:116805
- [8] Xiao Zhang, Yuchen Cui, Wenjie Sui, Mengqi Cheng, Xinyu Xu, Wanting Duan, Ziyi Cheng, Jiajia Fu, Yanmei Xu*, Youxin Li*, Steam explosion as a green pretreatment strategy to enhance total phenolics release and biological activities in Potentilla discolor Bunge stems, Molecules, 2026, 31(1): 139.
- [9] Xiaoqian Yuan, Yuchen Cui, Yaqin Nan, Ruijun Tang, Xinru Wang, Yanmei Xu*, Xinghua Jin*, Yiwen Wang*, Ding Cheng*, and Youxin Li*, A combination strategy of HPLC and boric acid modified β-CD polymer for super-efficiently separating chiral substances with O/N atoms in chiral and/or adjacent carbons, Analytica Chimica Acta, 2025, 1378: 344687.
- [10] Pingyi Zheng, Xinru Wang, Ruijun Tang, Yuchen Cui, Xiaoqian Yuan, and Youxin Li*, An efficient strategy for quickly determining adenosine deaminase and purine nucleoside phosphorylase kinetics and screening their inhibitors, International Journal of Biological Macromolecules, 2025, 321: 146545.
- [11] Pingyi Zheng, Jipeng Liu, Xiao Zhang, Xiaoqian Yuan, Xinyu Xu, James J. Bao*, and Youxin Li*, One-step method for rapid determination of enzyme kinetics and inhibition constants through the improved capillary electrophoresis, Microchemical Journal, 2025, 215:114268.
- [12] Pingyi Zheng†, Xinru Wang†, Yuchen Cui, Ruijun Tang, Hongjian Yu*, Lin Wang*, and Youxin Li*, Fast determination of protein binding constants and sites to active flavonoids and phenolic acids by affinity capillary electrophoresis and fluorescence spectroscopy, Chemical Biology & Drug Design, 2025, 106(1): e70148.
- [13] Yanmei Xu, Laiming Li, Pingyi Zheng, Ran Zhao, Mengqi Cheng, Yanfang Su*, James J. Bao*, and Youxin Li*, Purification of mogroside V from crude extract of Siraitia grosvenorii using boronic acid-functionalized silica gel and its hypoglycemic activity determination, Separations, 2025, 12:135.
- [14] Yunuo Ren†, Wen Zhang†, Youxin Li†, Dekun Wang†, Weiwei Tang, Lingfei Wang, Xinghua Jin, Donghai Xia, Wei Yu, Yaodong Miao, Yingjie Ju, Shushen Sun, Tianxiang Li, Shaoshan Du*, Zhimou Guo*, Xiaoyue Tan*, Zhiguang Yuchi*, and Yiwen Wang*, Streamlined strategy for discovering active compounds for nephrolithiasis treatment from herbal medicines using the fruit fly model, Journal of Ethnopharmacology, 2025, 348:119846.
- [15] Ran Zhao, Ruijun Tang, Zhiyuan Shi, Yanmei Xu, Xiao Zhang, Xinyu Xu, Xiaoqian Yuan, Yuchen Cui, Xinru Wang, and Youxin Li*, Six silica absorbents with nitrogen and boronic acid groups for in-situ separation of lactic acid in real fermentation broth, Separation and Purification Technology, 2025, 364:132482.
- [16] Yaqin Nan†, Xiaoqian Yuan†, Xinyu Xu, Yanmei Xu, Xinghua Jin, and Youxin Li*, Boric acid modified β-CD polymer as chiral selector for chiral drug separation using gravity mediated capillary electrophoresis, Microchemical Journal, 2025, 210:112890.
- [17] Ran Zhao, Ling Zhang, Kun Zhang, and Youxin Li*, Reform and exploration of the experimental teaching mode of teaching assistant and group rotation system: taking pharmaceutical analysis experiment course as an example, Chinese Journal of Chromatography, 2025, 43(2):197-203.
- [18] Wenhui Jia, Pingyi Zheng, Yuchen Cui, James J. Bao, Yanmei Xu, and Youxin Li*, A convenient and efficient strategy for improving separation ability of capillary electrophoresis through tilting capillary as needed, Separations, 2024, 11(12): 340.
- [19] Haijiao Jia†, Yuchen Cui†, Xiaoqian Yuan, Yanmei Xu, and Youxin Li*, Magnetic Ru nanocatalysts for green solvent-free oxidation reactions of aromatic alcohols, Journal of Organometallic Chemistry, 2024, 1021:123354.
- [20] Haijiao Jia†, Xinyu Xu†, Yuchen Cui†, Mengqi Cheng, Guirong Borjihan, Xiao Zhang, Shengbo Yang, and Youxin Li*, Solvent-free oxidation of alcohols by a heterogeneous Fe3O4@SiO2-DTPA-Ru nanocatalyst, Inorganic Chemistry Communications, 2024, 169:103055.
- [21] Haijiao Jia, Xiao Zhang, Guirong Borjihan, Shengbo Yang, and Youxin Li*, A green and pollution-free heterogeneous ruthenium catalyst anchoring on magnetic nanoparticles with FPBA and DTPA groups for oxidation of aromatic alcohols, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2024, 698:134547.
- [22] Yaqin Nan†, Pingyi Zheng†, Xiaoqian Yuan, Xinyu Xu, Xiao Zhang, and Youxin Li*, An economic, accessible and stable sulphated cyclodextrin polymer as selector for efficiently separating chiral drugs in HPLC, Microchemical Journal, 2024, 204:110974.
- [23] Wenqing Zheng†, Pingyi Zheng†, Ran Zhao†, Xinyu Xu, Xiao Zhang, Xiaoqian Yuan, Ying Xu, Zichuan Liu*, and Youxin Li*, Fe3O4@SiO2-Protein A-oHSV/CD63 Ab for capturing virus and exosomes, Journal of Analysis and Testing, 2024, 8:335-350.
- [24] Haijiao Jia, Mengqi Cheng, Ran Zhao, Pingyi Zheng, Fangfang Ren, Yaqin Nan, Mengting Huang, and Youxin Li*, Excellent Pd-loaded magnetic nanocatalyst on multicarboxyl and boronic acid biligands, ACS Omega, 2024, 9: 17817-17831.
- [25] Wenqing Zheng, and Youxin Li*, Research progress of exosomes in the treatment of diabetes, Chinese Journal of Analysis Laboratory, 2024, 43(2): 229-237.
- [26] Mengqi Cheng†, Qianyi Song†, Xiaoyu Zhang†, Pingyi Zheng, Ran Zhao, Youxin Li*, and Haixia Chen*, Phenylboronic acid and amino bifunctional modified adsorbent for quickly separating phenolic acids from crude extract of Clerodendranthus spicatus and evaluation of their antioxidant and hypoglycemic activities, Molecules, 2023, 28:7539.
- [27] Wenqing Zheng, Ran Zhao, Haijiao Jia, Yaqin Nan, Pingyi Zheng, Mengqi Cheng, and Youxin Li*, Preparation of a novel polymer microspheres and application in solid phase extraction combined with hollow fiber membrane system for capturing lactic acid from simulated fermentation broth, Reactive & Functional Polymers, 2023, 193:105741.
- [28] Yaqin Nan, Pingyi Zheng, Mengqi Cheng, Ran Zhao, Haijiao Jia, Qinggang Liang, Youxin Li*, and James J. Bao*, Enhancement of chiral drugs separation by a novel adjustable gravity mediated capillary electrophoresis combined with sulfonic propyl ether β-CD polymer, Analytica Chimica Acta, 2023, 1279:341781.
- [29] Qianyi Song, Mengqi Cheng, Hongxu Liu, Haijiao Jia, Yaqin Nan, Wenqing Zheng, Youxin Li*, and James J. Bao, Preparation of a phenylboronic acid and aldehyde bi-functional group modified silica absorbent and applications in removing Cr(VI) and reducing to Cr(III), RSC Advances, 2023, 13: 15554-15565.
- [30] Jia Liu, Qianyi Song, Youxin Li*, and James J. Bao*, Development of a polyallylamine hydrochloride hydrogel imprinted with xylose for the purification of xylose from sugar mixture, International Journal of Food Science and Technology, 2023, 58(3): 1423-1433. Q3, IF:3.3
- [31] Jia Liu, Qianyi Song, Wenqing Zheng, Wenhui Jia, Haijiao Jia, Yaqin Nan, Fangfang Ren, James Jianmin Bao, and Youxin Li*, Preparation of boronic acid and carboxyl-modified molecularly imprinted polymer and application in a novel chromatography mediated hollow fiber membrane to selectively extract glucose from cellulose hydrolysis, Journal of Separation Science, 2022, 45 (13): 2415-2428.
- [32] Fangfang Ren, Simin Liu, Wenqing Zheng, Qianyi Song, Wenhui Jia, Yaqin Nan, Haijiao Jia, Jia Liu, James Jianmin Bao, and Youxin Li*, Preparation of a novel heterogeneous palladium nanocatalyst based on carboxyl modified magnetic nanoparticles and its applications in Suzuki-Miyaura coupling reactions, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2022, 642: 128611.
- [33] Assefa Aschenaki, Fangfang Ren, Jia Liu, Wenqing Zheng, Qianyi Song, Wenhui Jia, James Jianmin Bao, and Youxin Li*, Preparation of a magnetic and recyclable superparamagnetic silica support with boronic acid group for immobilizing Pd catalysts and it applications in Suzuki reactions, RSC Advances, 2021, 11(53), 33692-33702.
- Patents
- [1] Youxin Li, Jianmin Bao, Laiming Li, Boronic acid modified silica-supported platinum catalyst, its preparation and application[P]. Patent No.: ZL201810043323.7, Granted: 27 April 2021.
- [2] Youxin Li, Jianmin Bao, Feifei Jia, Juanjuan He, Xue Li. Preparation of cyclodextrin-styrene-divinylbenzene microspheres and their application in chiral separation. Chinese Invention Patent, Patent No. ZL201710135164.9, granted on 22 February 2019.
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- [3] Youxin Li, Jianmin Bao, Futing Li. Preparation and application of an environmentally friendly supported platinum catalyst. Chinese Invention Patent, Patent No. ZL201610202400.X, granted on 27 November 2018.
- [4] Yong Zhang, Jianmin Bao, Youxin Li, Hongting Xiao, Xia Fu. Device for determining enantiomeric excess of compounds by capillary electrophoresis differential mobility mode. Chinese Invention Patent, Patent No. ZL201410442755.7, granted on 7 September 2016.
- [5] Youxin Li, Jianmin Bao, Guirong Bao. Method for determining free compound concentration, logD and protein binding rate of compounds in plasma. Chinese Invention Patent, Patent No. ZL201510017619.8, granted on 24 August 2016.
- [6] Youxin Li, Jianmin Bao, Lumeng Zhao. Novel electrophoresis microchip with large channel. Chinese Invention Patent, Patent No. ZL201410355409.5, granted on 24 August 2016.
- [7] Jianmin Bao, Jingsheng Xu, Zhishuang Ma, Yuanjin Zhang, Youxin Li. A sample preparation instrument. Chinese Invention Patent, Patent No. ZL201310050581.5, granted on 14 October 2015.
- [8] Jianmin Bao, Youxin Li, Feifei Jia, Qinggang Liang. Synthesis and application of cyclodextrin polymer chiral selector. Chinese Invention Patent, Patent No. ZL201210430431.2, granted on 1 October 2014.
- [9] Jianmin Bao, Zhengchang Zhou, Youxin Li. Automatic sampling tray of temperature-controllable microreactor with magnetic stirring function. Chinese Invention Patent, Patent No. ZL201210101275.5, granted on 14 August 2013.
- Honors & Awards
- [1] Excellent Youth Editorial Board Member of *Journal of Analysis and Testing* (JAT), 2025
- [2] Nominated for the Distinguished Mentor Award of Tianjin University in 2025.
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- [3] Winner of the 13th Excellent Teaching Plan Award, Tianjin University, 2025
- [4] Member of Tianjin Association for Instrumental Analysis
- [5] Excellent Mentor, Tianjin University, 2024
- [6] Winner of the Excellence Award in the 3rd Teaching Innovation Competition, Tianjin University, 2023
- [7] Excellent Instructor for Undergraduate Graduation Thesis, Tianjin University, 2022
- [8] Expert of the Expert Database of Tianjin Medical Products Administration, 2022
- [9] Special Prize (International Group), National College Students' Innovation and Entrepreneurship Experimental Teaching Reform Competition (National Level), 2018. Supervisors: Youxin Li. Team members: Haotian Wang, Sijie Liu, Jincong Yan, Hang Cao
- [10] Third Prize (Science Group), Internal Selection Competition of the 13th Tianjin Youth Teacher Basic Teaching Skills Competition, 2016
- [11] Excellent Oral Presentation Award, 10th National Symposium on Biomedical Chromatography and Related Academic Topics, Weihai, Shandong, 19–22 April 2014
- [12] Third annual SLAS Conference and Exhibition (SLAS2014), San Diego, CA, USA, 2014, January 18-22th, Tony B. Academic Travel Award.
- [13] Third Prize, the 9th Youth Teacher Teaching Competition, Tianjin University, 2012
- [14] First Prize, the 3rd Youth Teacher Teaching Competition, School of Pharmaceutical Science and Technology, Tianjin University, 2012