LIN ZHI
School
School of Life Sciences
Professional Title
Professor
Contact Information
zhi.lin@tju.edu.cn
Bldg. No.15, School of Life Sciences, Tianjin University, 92 Weijin Road, Tianjin
300072
Brief Introduction
Dr Lin Zhi is currently a Professor at the School of Life Sciences, Tianjin University. He received his PhD degree in Structural Biology from the National University of Singapore in 2006. After serving as a Research Fellow at the Department of Biological Sciences and Senior Research Fellow at the Department of Physiology at the National University of Singapore, he joined Tianjin University in late 2015 . His current research interests are protein structures, functions and bioengineering (http://www.linzhi.net).
Education Background
- Ph.D| National University of Singapore| Structural biology| 2006
Research Interests
- High-performance silk-based biomaterials: This research focuses on the structure-based engineering and design of fibroins for the production of artificial silk materials with desirable and tunable mechanical properties for potential industry, medical and military applications.
- Structural mechanisms of signaling: This research targets a variety of signaling proteins related to human development and diseases, including nerve growth & injury, cancers, and microbial infection.
Positions & Employments
-
2020.6-Now
School of Life Sciences | Tianjin University | Professor -
2015.11-2020.6
School of Life Sciences | Tianjin University | Principle Investigator -
2012.10-2015.11
National University of Singapore | Senior Research Fellow -
2009.8-2012.8
National University of Singapore | Research Fellow -
2007.8-2009.7
National University of Singapore & Singapore Millennium Foundation | Postdoctoral Fellow -
2006.9-2007.7
National University of Singapore | Research Assistant
Academic Achievements
- Papers
- [1] Representative Publications:
- [2] Wang J#, Fan T#, Li X#, Hu X, Huang W, Yuan W*, Lin Z* (2022) Artificial superstrong silkworm silk surpasses natural spider silks. Matter, 2022, 5(12): 4396-4406
-
- [3] Fan T#, Qin R#, Zhang Y#, Wang J#, Fan J#, Bai X, Yuan W, Huang W, Shi S, Su X, Yang D, Lin Z* (2021) Critical role of minor eggcase silk component in promoting spidroin chain alignment and strong fiber formation. PNAS, 118 (38) e2100496118.
- [4] Zhang N, Kisiswa L, Ramanujan A, Li Z, Sim EW, Yuan W, Ibáñez CF, Lin Z* (2021) Structural basis of NF-κB signaling by the p75 neurotrophin receptor interaction with adaptor protein TRADD through their respective death domains. J Biol Chem, 297(2):100916.
- [5] Yuan W, Ibáñez CF, Lin Z* (2019) Death domain of p75 neurotrophin receptor: a structural perspective on an intracellular signalling hub. Biol Rev, 94(4):1282-1293.
- [6] Goh ET#, Lin Z#, Ahn BY#, Lopes-Rodrigues V, Dang NH, Salim S, Berger B, Dymock B, Senger DL and Ibáñez CF* (2018) A small molecule targeting the transmembrane domain of death receptor p75NTR induces melanoma cell death and reduces tumor growth. Cell Chem Biol 25:1485-1494.
- [7] Lin Z, Tann, JY, Goh, ET. Kelly, C, Lim, KB, Gao, JF, Ibanez, CF* (2015) Structural basis of death domain signaling in the p75 neurotrophin receptor. eLife, 4:e11692
- [8] Lin Z, Deng Q, Liu XY, and Yang D* (2013) Engineered Large Spider Eggcase Silk Protein for Strong Artificial Fibers. Adv Mater, 25:1216-1220
- [9] Lin Z*, Huang W, Zhang J, Fan J, Yang D* (2009) Solution Structure of Eggcase Silk Protein and Its Implications for Silk Fiber Formation. PNAS, 106:8906-8911.
- [10] Lin Z, Sriskanthadevan S, Huang H, Siu CH*, Yang D* (2006) Solution structures of the adhesion molecule DdCAD-1 reveal new insights into Ca2+-dependent cell-cell adhesion. Nat Struct Mol Biol, 13:1016-1022.
- [11] Lin Z, Xu Y, Yang S, and Yang D* (2006) Sequence-specific assignment of aromatic resonances of uniformly 13C, 15N-labeled proteins by using 13C- and 15N-edited NOESY spectra. Angew Chem Int Ed, 45:1960-1963.