School of Life Sciences
Professor
zhi.lin@tju.edu.cn
Bldg. No.15, School of Life Sciences, Tianjin University, 92 Weijin Road, Tianjin
300072
Dr Lin Zhi is currently a Professor at the School of Life Sciences, Tianjin University. He received his PhD degree in Structural Biology from the National University of Singapore in 2006. After serving as a Research Fellow at the Department of Biological Sciences and Senior Research Fellow at the Department of Physiology at the National University of Singapore, he joined Tianjin University in late 2015 . His current research interests are protein structures, functions and bioengineering (http://www.linzhi.net).
- Ph.D| National University of Singapore| Structural biology| 2006
- High-performance silk-based biomaterials: This research focuses on the structure-based engineering and design of fibroins for the production of artificial silk materials with desirable and tunable mechanical properties for potential industry, medical and military applications.
- Structural mechanisms of signaling: This research targets a variety of signaling proteins related to human development and diseases, including nerve growth & injury, cancers, and microbial infection.
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2020.6-Now
School of Life Sciences | Tianjin University | Professor -
2015.11-2020.6
School of Life Sciences | Tianjin University | Principle Investigator -
2012.10-2015.11
National University of Singapore | Senior Research Fellow -
2009.8-2012.8
National University of Singapore | Research Fellow -
2007.8-2009.7
National University of Singapore & Singapore Millennium Foundation | Postdoctoral Fellow -
2006.9-2007.7
National University of Singapore | Research Assistant
- Papers
- [1] Zhang Y#, Gao X#, Xiao Y#, Duan Y, Xiao W, Xu Y, Yang T, Zhang H, Chen C, Shi S, Su XC, Jin X, Zhao J, Yang H, Yin G, Yuan W, Wang Z*, Huang W*, Lin Z* (2025) eATP sensing by the purinergic receptor PA2072 for allosteric modulation in intracellular c-di-GMP signaling. PNAS, 122(45): e2423664122.
- [2] Qin R#, Yang R#, Yu S, Guo W, Cong H, Ning Y,Chen C, Yang D, Yuan W*, Lin Z* (2025) Intrinsically disordered linkers and terminal domains co-drive aciniform spidroin self-assembly through liquid-liquid phase separation. PNAS 122(41):e2510216122.
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- [3] Wang J#, Fan T#, Li X#, Hu X, Huang W, Yuan W*, Lin Z* (2022) Artificial superstrong silkworm silk surpasses natural spider silks. Matter, 2022, 5(12): 4396-4406
- [4] Fan T#, Qin R#, Zhang Y#, Wang J#, Fan J#, Bai X, Yuan W, Huang W, Shi S, Su X, Yang D, Lin Z* (2021) Critical role of minor eggcase silk component in promoting spidroin chain alignment and strong fiber formation. PNAS, 118 (38) e2100496118.
- [5] Yuan W, Ibáñez CF, Lin Z* (2019) Death domain of p75 neurotrophin receptor: a structural perspective on an intracellular signalling hub. Biol Rev, 94(4):1282-1293.