School of Pharmaceutical Science and Technology
Associate professor
mengxj_23@tju.edu.cn
My research focuses on drug metabolism and the in vivo fate of complex drug systems. I have published over 30 papers in journals such as Acta Pharmaceutica Sinica B, Analytical Chemistry, Nano Letters, Journal of Pharmaceutical Analysis, International Journal of Biological Macromolecules, and Talanta, and currently lead projects funded by the National Natural Science Foundation of China and the Natural Science Foundation of Tianjin. I serve as a Young Editorial Board Member of Journal of Pharmaceutical Analysis, Pharmaceutical Science Advances, Chinese Chemical Letters, and Journal of Analysis and Testing, and as a member of the Pharmaceutical Analysis Technology Branch of the China Medicinal Biotech Association, the Specialized Committee on Clinical Research Quality and Evaluation of the China Association of Pharmaceutical Quality Management, and the Youth Science and Technology Work Committee of the Tianjin Analysis and Testing Association.
- 药物代谢与药物动力学
- 复杂药物体系的体内过程
- Journal of Analysis and Testing青年编委
- Chinese Chemical Letters青年编委
- Pharmaceutical Science Advances青年编委
- Journal of Pharmaceutical Analysis青年编委
- 天津市分析测试协会青年科技工作委员会委员
- 中国医药质量管理协会“临床研究质量与评价专业委员会”委员
- 中国医药生物技术协会药物分析技术分会委员
- Papers
- [1] J. Yao, J. Wang, P. Bu, K. Liu, M. Zhao, J. Gu *, X. Meng *, The impact of the DiI fluorescent probe on the in vivo fate of paclitaxel-loaded methoxy polyethylene glycol-block-poly (d,l-lactide) micelles, Drug Metab Dispos, 54 (2026) 100372. 中科院分区/药学2区
- [2] X. Wang, J. Yao, M. Zhao, H. Wang, J. Gu *, X. Meng *, Deciphering the in vivo metabolism of polyethylene glycol by a polymeromics approach, Anal Chem, 98 (2026) 5634-5643. 中科院分区/化学1区TOP
-
- [3] H. Wang, X. Wang, J. Yao, X. Meng *, Direct measurement of critical micelle concentrations of mPEG-PLA copolymers based on ultrafiltration combined with liquid chromatography tandem mass spectrometry, J Chromatogr A, 1779 (2026) 467056. 中科院分区/化学2区TOP
- [4] M. Li, X. Meng *, Recent advances in bioanalytical technologies for oligonucleotide therapeutics: Technical progress and methodological challenges, Chin Chem Lett, (2026) 112501. 中科院分区/化学1区TOP
- [5] J. Yao, J. Sun, X. Wang, H. Wang, Y. Liu, M. Zhao, X. Meng *, J. Gu *, Label-free analysis reveals in vivo premature drug release governed by diffusion from polymeric micelles, Nano Lett, 25 (2025) 18132-18140. 中科院分区/化学1区
- [6] X. Xu, H. Yang, J. Chi, H. Sun *, X. Meng *, J. Gu *, Pharmacokinetics, tissue distribution and metabolism of hydroxyethyl starch 130/0.4 in rats, Int J Biol Macromol, 309 (2025) 142684. 中科院分区/生物学2区TOP
- [7] X. Xu, H. Yang, J. Chi, X. Meng *, J. Gu *, Full-profile bioanalysis of polydisperse macromolecular hydroxyethyl starch 130/0.4 in rat plasma via LC-IS-CID coupled with MRM, Chin Chem Lett, (2025) 111703. 中科院分区/化学1区TOP
- [8] X. Meng, J. Yao, J. Gu *, Advanced bioanalytical techniques for pharmacokinetic studies of nanocarrier drug delivery systems, J Pharm Anal, 15 (2025) 101070. 中科院分区/医学1区TOP
- [9] X. Meng, C. Su, Z. Zhang, Y. Li, Y. Zhang, J. Li, L. Gan, J. Gu *, Overcoming the challenge of potent endogenous interferences in limaprost quantification: An innovative methodology combining differential mobility spectrometry with LC-MS/MS for ultra-high sensitivity, selectivity and significantly enhanced throughput, Talanta, 277 (2024) 126411. 中科院分区/化学2区TOP
- [10] X. Meng, Z. Zhang, J. Tong, H. Sun, J.P. Fawcett, J. Gu *, The biological fate of the polymer nanocarrier material monomethoxy poly(ethylene glycol)-block-poly(d,l-lactic acid) in rat, Acta Pharm Sin B, 11 (2021) 1003-1009. 中科院分区/医学1区TOP
- [11] X. Meng #, H. Pang #, F. Sun, X. Jin, B. Wang, K. Yao, L. Yao, L. Wang, Z. Hu *, Simultaneous 3-nitrophenylhydrazine derivatization strategy of carbonyl, carboxyl and phosphoryl submetabolome for LC-MS/MS-based targeted metabolomics with improved sensitivity and coverage, Anal Chem, 93 (2021) 10075-10083. 中科院分区/化学1区TOP




