Mu Xin
School
School of Pharmaceutical Science and Technology, Medical College
Professional Title
Associate professor
Administrative Appointments
副院长
Contact Information
xin_mu@tju.edu.cn
Building 24, Room 310-4；A208
300072
Education Background
- Doctoral degree| Institute of Biophysics, CAS| Biochemistry and Molecular Biology| 2013
- Bachelor’s Degree| Tianjin University| Science Pharmaceutical| 2005
Research Interests
- Our group is centered on the core scientific question of how cell death fate is co-determined by intrinsic recognition programs and immune–virus interplay.
Courses
Positions & Employments
-
2015.1-2019.12
Boston Children's Hospital / Harvard Medical School | Post-doc -
2014.1-2015.12
Institute of Microbiology, CAS | Post-doc -
2013.1-2014.12
Institute of Biophysics, CAS | Research Assistant
Academic Achievements
- Papers
- [1] Mu, X., Li, W., Wang, X., & Gao, G*. (2013). YB-1 stabilizes HIV-1 genomic RNA and enhances viral production. Protein & cell, 4(8), 591–597. https://doi.org/10.1007/s13238-013-3011-3
- [2] Mu, X., Fu, Y., Zhu, Y., Wang, X., Xuan, Y., Shang, H., Goff, S. P., & Gao, G*. (2015). HIV-1 Exploits the Host Factor RuvB-like 2 to Balance Viral Protein Expression. Cell host & microbe, 18(2), 233–242. https://doi.org/10.1016/j.chom.2015.06.018
-
- [3] Mu, X., Ahmad, S., & Hur, S*. (2016). Endogenous Retroelements and the Host Innate Immune Sensors. Advances in immunology, 132, 47–69. https://doi.org/10.1016/bs.ai.2016.07.001
- [4] Ahmad, S.#, Mu, X.#, Yang, F.#, Greenwald, E., Park, J. W., Jacob, E., Zhang, C. Z., & Hur, S. (2018). Breaching Self-Tolerance to Alu Duplex RNA Underlies MDA5-Mediated Inflammation. Cell, 172(4), 797–810.e13. https://doi.org/10.1016/j.cell.2017.12.016
- [5] Mu, X., Greenwald, E., Ahmad, S., & Hur, S*. (2018). An origin of the immunogenicity of in vitro transcribed RNA. Nucleic acids research, 46(10), 5239–5249. https://doi.org/10.1093/nar/gky177
- [6] Ahmad, S., Mu, X., & Hur, S*. (2021). The Role of RNA Editing in the Immune Response. Methods in molecular biology (Clifton, N.J.), 2181, 287–307. https://doi.org/10.1007/978-1-0716-0787-9_17
- [7] Kato, K., Ahmad, S., Zhu, Z., Young, J. M., Mu, X., Park, S., Malik, H. S., & Hur, S*. (2021). Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases. Molecular cell, 81(3), 599–613.e8. https://doi.org/10.1016/j.molcel.2020.11.047
- [8] Mu, X.*, & Hur, S*. (2021). Immunogenicity of In Vitro-Transcribed RNA. Accounts of chemical research, 54(21), 4012–4023. https://doi.org/10.1021/acs.accounts.1c00521
- [9] Li, W., Yang, H., Mu, X*. (2022) The Relationship Between The Regulation of Interferon Signaling Pathway and The Occurrence of Autoimmune Diseases. Progress in Biochemistry and Biophysics, 49(8), 1445-1452. https://doi.org/10.16476/j.pibb.2021.0282
- [10] Ji, X., Meng, W., Liu, Z.*, & Mu, X*. (2022). Emerging Roles of lncRNAs Regulating RNA-Mediated Type-I Interferon Signaling Pathway. Frontiers in immunology, 13, 811122. https://doi.org/10.3389/fimmu.2022.811122
- [11] Li, X., Sun, X., Guo, X., Li, X., Peng, S.*, & Mu, X*. (2022). Chemical reagents modulate nucleic acid-activated toll-like receptors. Biomedicine & pharmacotherapy, 147, 112622. https://doi.org/10.1016/j.biopha.2022.112622
- [12] Guo, X.*, Zeng, S., Ji, X., Meng, X., Lei, N., Yang, H., & Mu, X*. (2022). Type I Interferon-Induced TMEM106A Blocks Attachment of EV-A71 Virus by Interacting With the Membrane Protein SCARB2. Frontiers in immunology, 13, 817835. https://doi.org/10.3389/fimmu.2022.817835
- [13] Gao, D., Ciancanelli, M. J., Zhang, P., Harschnitz, O., Bondet, V., Hasek, M., Chen, J., Mu, X., Itan, Y., Cobat, A., Sancho-Shimizu, V., Bigio, B., Lorenzo, L., Ciceri, G., McAlpine, J., Anguiano, E., Jouanguy, E., Chaussabel, D., Meyts, I., Diamond, M. S., … Zhang, S. Y. (2021). TLR3 controls constitutive IFN-β antiviral immunity in human fibroblasts and cortical neurons. The Journal of clinical investigation, 131(1), e134529. https://doi.org/10.1172/JCI134529
- [14] Pang, Z., Wang, Z., Li, F., Feng, C.*, & Mu, X*. (2022). Current Progress of CAR-NK Therapy in Cancer Treatment. Cancers, 14(17), 4318. https://doi.org/10.3390/cancers14174318
- [15] Yang, H., Ji, X., Li, X., Feng, Y., Zhang, K., Guo, X.*, Zhong, Z.*, & Mu, X*. (2023). Colorimetry-Based Phosphate Measurement for Polymerase Elongation. BioMed research international, 2023, 8296847. https://doi.org/10.1155/2023/8296847
- [16] Paget, M., Cadena, C., Ahmad, S., Wang, H. T., Jordan, T. X., Kim, E., Koo, B., Lyons, S. M., Ivanov, P., tenOever, B., Mu, X., & Hur, S*. (2023). Stress granules are shock absorbers that prevent excessive innate immune responses to dsRNA. Molecular cell, 83(7), 1180–1196.e8. https://doi.org/10.1016/j.molcel.2023.03.010
- [17] Li, X., Sun, X., Yan, Z., Zhao, Z., Pang, Z., Yang, H., Ji, X., Lei, Y., Zhu, Z.*, Guo, X.*, & Mu, X*. (2023). New role of gramicidin A in RIG-I-like receptors-mediated IFN signalling. Immunology, 169(2), 219–228. https://doi.org/10.1111/imm.13626
- [18] Zhang, Q., Yang, Y., Lan, J., Wang, Z., Gao, Y., Li, X., Mao, W., Xie, J., Mi, L. Z., Zhang, X., Wang, X., Mu, X.*, & Mei, K*. (2023). Inducing enhanced neutralizing antibodies against broad SARS-CoV-2 variants through glycan-shielding multiple non-neutralizing epitopes of RBD. Frontiers in immunology, 14, 1259386. https://doi.org/10.3389/fimmu.2023.1259386
- [19] Wang, Z., Li, F., Feng, C., Zheng, D., Pang, Z., Ma, Y., Xu, Y., Yang, C., Li, X., Peng, S.*, Liu, Z.*, & Mu, X*. (2024). 1-Naphthaleneacetic Acid Improved the In Vitro Cell Culturing by Inhibiting Apoptosis. Advanced biology, 8(3), e2300593. https://doi.org/10.1002/adbi.202300593
- [20] Liu, J., Liu, L., Zeng, S., Meng, X., Lei, N., Yang, H., Li, R., Mu, X.*, & Guo, X*. (2024). Inhibition of EV71 replication by an interferon-stimulated gene product L3HYPDH. Virus research, 342, 199336. https://doi.org/10.1016/j.virusres.2024.199336
- [21] Li, F., Wang, Z., Zheng, D., Pang, Z., Feng, C., Ma, Y., Yang, C., Li, X., Peng, S.*, Liu, Z.*, & Mu, X*. (2024). NK92 cells and peripheral blood NK cells respond oppositely upon dasatinib treatment. Immunology, 172(1), 163–177. https://doi.org/10.1111/imm.13768
- [22] Jiang, N., Yang, H., Lei, Y., Qin, W., Xiong, H., Chen, K., Mei, K., Li, G., Mu, X.*, & Chen, R.* (2025). Characterization of dsRNA binding proteins through solubility analysis identifies ZNF385A as a dsRNA homeostasis regulator. Nature communications, 16(1), 3433. https://doi.org/10.1038/s41467-025-58704-7
- [23] Li, P., Li, F., Hou, X., Li, X., Mu, X.*, Liu, H.*, & Peng, S*. (2025). Immunotherapy for Lung Cancer. Progress in Biochemistry and Biophysics, 52(8), 1998-2017. https://doi.org/10.16476/j.pibb.2025.0038
- [24] Pang, Z., Yang, H., Li, B., Liu, Y., Zhao, Z., Zhu, Z., Peng, S.*, Mu, X.*, & Yu, H*. (2025). Screening and Validation of Negative Regulators of the Type I Interferon Pathway. Advanced biology, 9(11), e00736. https://doi.org/10.1002/adbi.202400736
- [25] Liu, Y., Zhao, Z., Ji, X., Lei, Y., Zheng, D., Huang, Y., An, J., Gao, C., Wang, Z., Si, Y., Chen, X., Li, X., Peng, S., Yu, H., Liu, Z.*, Zhu, Z.*, & Mu, X*. (2026). HSPA6 is induced by RIG-I-like receptors and negatively regulates type-I interferon signaling. Cellular and molecular life sciences : CMLS, 83(1), 137. https://doi.org/10.1007/s00018-026-06147-8
- [26] Zheng, D., Li, F., Zhang, Z., Dong, Y., Zhang, X., Li, X., Yang, J., Peng, S.*, Chen, B.*, Sun, S.*, Liu, Z.*, & Mu, X*. (2026). TFPI2 promotes NK cell-mediated glioblastoma killing through adhesion and checkpoint control. Proceedings of the National Academy of Sciences of the United States of America, 123(25), e2529973123. https://doi.org/10.1073/pnas.2529973123