刘志华，博士生导师，天津大学“北洋学者英才计划”特聘研究员/长聘副教授、国家重点研发计划项目首席科学家。先后获得天津大学生物工程学士学位、生物化工硕士学位，中国科学院大学生物化工博士学位；曾在美国Texas A&M University从事博士后研究（Postdoctoral Researcher）、任研究员（Research Scientist）。

迄今为止，在Nature Communications, The Innovation、Trends in Biotechnology、Renewable & Sustainable Energy Reviews、Biotechnology Advances、JACS Au、Green Chemistry、Chemical Engineering Journal、Bioresource Technology、ACS Sustainable Chemistry & Engineering等国际权威学术期刊发表SCI论文100余篇。Springer出版社特邀主编“生物炼制”领域英文专著，参编英文专著5部，申请专利20余项。论文累计引用5000余次，H因子36，i10因子62，20余篇SCI论文入选ESI高被引、Nat. Commun.、Trends Biotechnol.、JACS Au、Green Chem.期刊亮点、封面文章等。Green Chem.特邀组织建刊25周年“生物炼制”专刊、Curr. Opin. Biotechnol.期刊“能源技术”专刊，担任Carbon Resour. Convers.、Green Carbon等多个SCI期刊（青年）编委，受邀担任Nature Commun.、Adv. Sci.等五十余种国际期刊审稿人，参加国内外会议做大会、主旨、邀请或口头报告五十余次，研究成果被数十家媒体报道。

• 国家重点研发计划“前沿生物技术”重点专项首席科学家

• 天津市高层次青年人才计划（海外）

• 天津大学“北洋学者英才计划”（海外）

• 天津大学博士研究生导师“登峰计划”“青年先锋导师”

• 2021-2025年连续5年入选美国斯坦福大学全球前2%科学家榜单

• 江苏省高层次创新创业人才引进计划（双创人才）

• 江苏省南通市“江海英才”高层次创业领军型人才

• 江苏省南通市海门“东洲英才”高层次创业领军型人才

• 中国化工学会生物化工青年委员会委员

• 2023-2025年连续三年研究生国家奖学金指导教师（硕士6人、博士1人）

• 2024-2025年连续两年天津大学研究生优秀毕业论文指导教师（硕士5人）

• 2023-2025年连续三年天津大学本科生优秀毕业论文指导教师（6人）

• 国家级大学生创新创业项目指导教师

• 天津大学化工学院领军班班导师

• 天津大学化工学院/合成生物学学院师友导师

• 第五、六届生物化工青年论坛优秀青年学者报告奖

• 2024生物化工助力“双碳战略”发展论坛优秀口头报告奖

研究方向

• 生物炼制与生物产物

• 系统与合成生物技术

• 微生物细胞工厂构建

• AI辅助的酶设计改造

博士、硕士研究生招生专业：制药工程、生物工程、生物与医药（专业）

欢迎有志于科研，具有制药工程、生物工程、合成生物学、化工、化学、计算机等相关专业背景的同学报考博士和硕士研究生，请联系zhliu@tju.edu.cn；

此外，课题组与美国、欧洲等著名学府、实验室建立了密切合作关系，可以为有出国深造的同学提供国际交流和出国深造机会。

• 生物炼制与生物产物
        针对生物质利用关键问题与挑战，研究生物炼制一般共性规律与原理，提出全新生物炼制理念，构建新型生物炼制技术体系
  
  
• 系统与合成生物技术
        利用系统与合成生物学全新技术，设计构建高效的工程菌株，开发全新合成生物路径，实现可再生生物质资源高效生物转化
  
  
• 微生物细胞工厂构建
        针对生物基产物合成难题，阐明微生物细胞工厂的构建原则，设计开发高效微生物细胞工厂，生产清洁能源、化学品和材料
  
  
• AI辅助的酶设计改造
        针对生物转化酶效率低问题，开发AI辅助酶设计改造新方法，建立生物转化核心酶高效改造表达体系，提升生物催化效率
  

• 国家重点研发计划项目首席科学家
• 天津市高层次青年人才计划（海外）
• 天津大学“北洋学者英才计划”（海外）
• 天津大学博士研究生导师“登峰计划”“青年先锋导师”
• 2021-2025连续5年入选美国斯坦福大学全球前2%科学家榜单
• 江苏省高层次创新创业人才引进计划（双创人才）
• 江苏省南通市“江海英才”高层次创业领军型人才
• 江苏省南通市海门“东洲英才”高层次创业领军型人才
• 中国化工学会生物化工青年委员会委员
• 研究生国家奖学金指导教师
• 天津大学研究生优秀毕业论文指导教师
• 天津大学本科生优秀毕业论文指导教师
• 国家级大学生创新创业项目指导教师
• 天津大学化工学院/合成生物学学院师友导师
• 天津大学化工学院领军班班导师

• Zhi-Hua Liu *, He Liu, Tao Xu, Zhi-Min Zhao, Arthur J Ragauskas, Bing-Zhi Li *, Joshua S Yuan, Ying-Jin Yuan. Lignin Valorization Reshapes Sustainable Biomass Refining. Renewable & Sustainable Energy Reviews, 2024 (一区 ESI高被引论文)；
• Zhi-Hua Liu, Bing-Zhi Li, Joshua S. Yuan, James Clark, Vânia Zuin Zeidler, Lieve Laurens, Arthur J. Ragauskas, João A. P. Coutinho, Buxing Han. Exploring the Frontiers: Unveiling New Horizons in Carbon Efficient Biomass Utilization. Green Chemistry, 2025 (一区)
• Ya Zhou#, Ruo-Ying Liu#, Ning Fu, Xia Li*, Bing-Zhi Li, Zhi-Hua Liu*. Artificial biological funnel design enabled valorization of aromatic derivatives into catechol. Journal of Agricultural and Food Chemistry, 2025 (一区 封面论文)
• Na Li#, Si-Yu Zhu#, Ling-Ling Bai, Bing-Zhi Li*, Zhi-Hua Liu*. Revolutionizing Lignin Valorization: Key Advances in Demethylation, Methylation, and Methyl Metabolism. Biotechnology Advances, 2025, 83, 108634 (一区)
• Zi-Jing He, Tao Xu, Shi-Chang Liu, Arthur J. Ragauskas, Bing-Zhi Li*, Ying-Jin Yuan, Zhi-Hua Liu*. Structure-function-guided synergistic fractionation enhances valorization of wheat straw biomass. Chemical Engineering Journal, 2025, 508: 160712. (一区)
• Ruo-Ying Liu, Bing-Zhi Li*, Ying-Jin Yuan, Zhi-Hua Liu*. Multiscale Metabolic Engineering in Biological Lignin Valorization. The Innovation, 2025 (一区)
• Hai-Yuan Jia#, Tao Xu#, Chen Wang, Hong-Wei Zhu, Bing-Zhi Li, Ying-Jin Yuan, Zhi-Hua Liu*. Emerging Biotechnological Strategies Advancing Biological Lignin Valorization Towards Polyhydroxyalkanoates. Bioresource Technology, 2025: 132278. (一区)
• Ning Fu, Ruo-Ying Liu, Ya Zhou, Bing-Zhi Li*, Ying-Jin Yuan, Zhi-Hua Liu*. Technological Advances in Ligninolytic Enzymes for the Biological Valorization of Lignin. Green Chemistry, 2025, 27, 4016 (一区)
• Si-Yu Zhu, Na Li, Zhi-Hua Liu*, Ying-Jin Yuan, Bing-Zhi Li*. Engineering budding yeast for the de novo synthesis of valuable flavanone derivatives, Green Chemistry, 2024 (一区)；
• Xin Xin, Dan-Feng Liu, Shi-Chang Liu, Zhi-Hua Liu*, Ying-Jin Yuan, Bing-Zhi Li*. Redesigned pathway for de novo synthesis of vanillin and co-conversion of multiple renewable substrates in Saccharomyces cerevisiae. JACS Au, 2024；
• Ruo-Ying Liu, Hai-Na Lan, Zhi-Hua Liu *, Bing-Zhi Li *, Ying-Jin Yuan. Microbial valorization of lignin toward coumarins: challenges and perspectives, Renewable & Sustainable Energy Reviews, 2024, 191, 114205 (一区)；
• Ruo-Ying Liu, Zhi-Hua Liu *, Bing-Zhi Li *, Ying-Jin Yuan. Biotransfromation of lignin into 4-vinylphenol derivatives toward lignin valorization, Green Chemistry, 2024 (一区)；
• Chen Wang, Ruo-Ying Liu, Zhi-Hua Liu *, Bing-Zhi Li *, Ying-Jin Yuan. Valorizing lignin and co-precursors into homogeneous polyhydroxyalkanoates by engineered Pseudomonas putida, ACS Sustainable Chemistry & Engineering, 2024 (一区)；
• He Liu, Tao Xu, Samuel S. Ntakirutimana, Zhi-Hua Liu*, Bing-Zhi Li*, Ying-Jin Yuan. Engineering Pseudomonas putida for lignin bioconversion into cis-cis muconic acid. Chemical Engineering Journal, 2024 (一区)；
• Ruo-Ying Liu, Chen Wang, Bing-Zhi Li *, Zhi-Hua Liu *, Ying-Jin Yuan. One-pot bioconversion of lignin to 4-vinylphenol derivatives, Chemical Engineering Journal, 2024, 499, 156286 (一区)；
• Xiao-Lei Zhang, Zhi-Hua Liu *, Bing-Zhi Li *, Ying-Jin Yuan. Tapping into the natural aromatic potential: microbial lignin valorization towards aromatic fine chemicals, Green Chemistry, 2024 (一区)；
• Zhi-Hua Liu, Naijia Hao, Yun-Yan Wang, Chang Dou, Furong Lin, Rongchun Shen, Renata Bura, David B. Hodge, Bruce E Dale, Arthur J. Ragauskas, Bin Yang, Joshua S. Yuan*. Transforming biorefinery designs with ‘plug-in processes of lignin’ to enable economic waste valorization, Nature Communications, 2021, 12, 3912. (Editors' Highlights, Featured articles in “Energy”, ESI Highly cited paper, 一区)
• Zi-Jing He, Kai Chen, Zhi-Hua Liu*, Bing-Zhi Li*, Ying-Jin Yuan. Valorizing renewable cellulose from lignocellulosic biomass toward functional products. Journal of Cleaner Production, 2023, 414:137708 (一区)
• Tao Xu, Qiu-Jin Zong, He Liu, Li Wang, Zhi-Hua Liu*, Bing-Zhi Li, Ying-Jin Yuan. Identifying ligninolytic bacteria for lignin valorization to bioplastics. Bioresource Technology, 2022, 127383. (一区)
• Qiu-Jin Zong, Tao Xu, He Liu, Li Xu, Ren-Kuan Zhang, Bing-Zhi Li, Zhi-Hua Liu*, Ying-Jin Yuan. Microbial valorization of lignin to bioplastic by genome-reduced Pseudomonas putida. Frontiers in Microbiology, 2022, 13
• Samuel Ntakirutimana, Tao Xu, Ming-Zhu Ding, Zhi-Hua Liu*, Bing-Zhi Li*, Ying-Jin Yuan. Chemomechanical pretreatment for efficient delignification and saccharification of corn stover biomass. Chemical Engineering Journal, 2023, 2023, 471, 144588 (一区)
• Kai Chen, Tao Xu, Shi-Chang Liu, Li Wang, Jia-Qi Cui, Zhi-Hua Liu*, Bing-Zhi Li*, Ying-Jin Yuan. Tandem fractionation technologies (TAFT) benefit multi-functional porous carbon toward lignin valorization. Chemical Engineering Journal, 2023, 474，145815. (一区)
• Zhi-Hua Liu, Naijia Hao, Somnath Shinde, Yunqiao Pu, Xiaofeng Kang, Arthur J Ragauskas, Joshua S. Yuan*, Defining lignin nanoparticle properties through tailored lignin reactivity by sequential organosolv fragmentation approach (SOFA). Green Chemistry, 2019, 21(2), 245-260. (Cover Story一区)
• Zhi-Hua Liu #, Rosemary K. Le #, Matyas Kosa, Bin Yang, Joshua S.Yuan*, Arthur J. Ragauskas*. Identifying and creating pathways to improve biological lignin valorization, Renewable & Sustainable Energy Reviews, 2019, 105, 349-362 (一区)
• Bing Xu, Qiang Li, Yunqiao Pu, Shangxian Xie, Arthur Ragauskas, Jorge Arreola-Vargas, Zhi-Hua Liu*, Joshua Yuan*. A unique bacterial pelletized cultivation platform in Rhodococcus opacus PD630 enhanced lipid productivity and simplified harvest for lignin bioconversion. ACS Sustainable Chemistry & Engineering, 2021, 10, 1083-1092. (一区)
• Zhi-Hua Liu, Somnath Shinde, Shangxian Xie, Naijia Hao, Furong Lin, Man Li, Chang Geun Yoo, Arthur J. Ragauskas, Joshua S. Yuan*. Cooperative valorization of lignin and residual sugar to polyhydroxyalkanoate (PHA) for enhanced yield and carbon utilization in biorefineries, Sustainable Energy & Fuels, 2019, 3, 2024-2037.
• Zhi-Hua Liu, Hong-Zhang Chen*. Simultaneous saccharification and co-fermentation for improving the xylose utilization of steam exploded corn stover biomass at high solid loading. Bioresource Technology, 2016, 201, 15-26. (一区)
• Zhi-Hua Liu, Bing-Zhi Li*, Joshua S. Yuan, Ying-Jin Yuan. Creative biological lignin conversion routes toward lignin valorization. Trends in Biotechnology, 2022 (一区Best of 2022: Trends in Biotechnology；ESI高被引论文)
• Zhi-Hua Liu, Naijia Hao, Somnath Shinde, Michelle L. Olson, Samarthya Bhagia, John R. Dunlap, Katy C. Kao, Xiaofeng Kang, Arthur J. Ragauskas, Joshua S. Yuan*. Co-design of combinatorial organosolv pretreatment (COP) and lignin nanoparticles (LNPs) in biorefineries. ACS Sustainable Chemistry & Engineering, 2018, 7(2), 2634–2647. (一区)
• Zhi-Hua Liu, Hong-Zhang Chen*. Biomass-water interaction and its correlations with enzymatic hydrolysis of steam exploded corn stover. ACS Sustainable Chemistry & Engineering, 2016, 4(3), 1274-1285. (一区)
• Zhi-Hua Liu, Shangxian Xie, Furong Lin, Mingjie Jin, Joshua Yuan*, Combinatorial pretreatment and fermentation optimization enabled a record yield on lignin bioconversion. Biotechnology for Biofuels, 2018, 11, 21 (一区)
• Zhi-Hua Liu, Michelle L. Olson, Somnath Dattatray Shinde, Xin Wang, Naijia Hao, Chang Geun Yoo, Samarthya Bhagia, John R. Dunlap, Yunqiao Pu, Katy Kao, Arthur J. Ragauskas, Mingjie Jin and Joshua S. Yuan*. Synergistic maximization of carbohydrate output and lignin processibility by combinatorial pretreatment. Green Chemistry, 2017, 19, 4939-4955. (一区)