• Papers

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• [1] Structure-guided screening identifies Tucatinib as dual inhibitor for MCT1/2, Binghong Xu#*, Xiaoyu Zhou#, Yuanyue Shan#, Sai Shi#, Jiachen Li#, Qinqin Liang, Ziyu Wang, Mingfeng Zhang*, Yaxin Wang*, Duanqing Pei*, Sheng Ye*, EMBO reports, 2025,12,11
• [2] A rationally designed cocktail of nanobodies elicited by heterologous vaccination confers protection against SFTSV in preclinical models, Xilin Wu*†, Linjing Zhu†, Shengjian Liang†, Zhen Chang†, Yaxin Wang†, Qingcui Zou†, Zhiyong Lou*, Minghua Li*, Yan Wu*, Zhiwei Wu*, Science Translational Medicine, 2025.11.19
• • [3] Structural and functional characterization of thermostable dUTPase P45 from Pyrococcus furiosus with enhanced PCR efficiency Bingjie Dong1¶*, Jiachen Li1¶, Lurong Zhang1¶, Bo Zhang2, Binghong Xu1,*, Sheng Ye1,*, Yaxin Wang1,*, International Journal of Biological Macromolecules, 2025.
  • [4] Bardoxolone methyl blocks the efflux of Zn2+ by targeting hZnT1 to inhibit the proliferation and metastasis of cervical cancer, Yaxin Wang#, Qinqin Liang#, Shengjian Liang#, Yuanyue Shan#, Sai Shi#, Xiaoyu Zhou, Ziyu Wang, Zhili Xu, Duanqing Pei, Mingfeng Zhang*, Zhiyong Lou*, Binghong Xu*, Sheng Ye*, Protein & Cell, 2025
  • [5] Transport mechanism and drug discovery of human monocarboxylate transporter 1 Sai Shi, Jia-chen Li, Xiao-yu Zhou, Zhen-lu Li, Ya-xin Wang*, Bing-hong Xu*, Sheng Ye*, Acta Pharmacologica Sinica volume 46, pages2323–2333 (2025).
  • [6] Etoposide targets 2A protease to inhibit enterovirus 71 replication Qinqin Liang #, Sai Shi #, Qingjie Zhang, Yaxin Wang*, Sheng Ye*, Binghong Xu*，Microbiology Spectrum, 2025.01
  • [7] Structural definition of pseudorabies virus dUTPase reveals a novel folding dimer in the herpesvirus family, Jiachen Li, Sen Ma, Runze Yang, Jinrui Xu, Yaxin Wang, Sheng Ye. International Journal of Biological Macromolecules, 2024. 09
  • [8] Sen Ma#, Doudou Zhang#, Qiwei Wang, Linjing Zhu, Xilin Wu*, Sheng Ye*, Yaxin Wang*.Structure defining of ultrapotent neutralizing nanobodies against MERS-CoV with novel epitopes on receptor binding domain. PLos Pathogens. 2024
  • [9] Linjing Zhu#, Bilian Huang#, Xiangyao Wang#, Sheng Ye, Yaxin Wang*, Yalan Liu*, Xilin Wu*. Ultrahigh-potent and broadly neutralizing anti-CD4 trimeric nanobodies inhibit HIV-1 infection by inducing CD4 conformational alteration. Nature Communications. 2024.
  • [10] Sen Ma#, Sai Shi#, Binghong Xu#, Meijun Liu, Lei Xie, Yang Su, Jiachen Li, Qinqin Liang, Sheng Ye1*, Yaxin Wang*, Host serine protease ACOT2 assists DENV proliferation by hydrolyzing viral polyproteins, msystems, 2023,12
  • [11] Qingdian Yin#, Jiaxing Zhang#, Sen Ma#, Tao Gu, Mengfan Wang, Shengping You*, Sheng Ye*, Rongxin Su, Yaxin Wang *, Wei Qi*, Efficient polyethylene terephthalate biodegradation by an engineered Ideonella sakaiensis PETase with a fixed substrate binding W156 residue, Efficient polyethylene terephthalate biodegradation by an engineered Ideonella sakaiensis PETase with a fixed substrate binding W156 residue, Green Chemistry, 2023, 11
  • [12] Lei Xie#, Sai Shi#, Lin Cheng, Binghong, Sen Ma, Jie Liu, Xilin Wu*,Yaxin Wang*, Sheng Ye*,Dauricine interferes with SARS-CoV-2 variants infection by blocking the interface between RBD and ACE2,International Journal of Biological Macromolecules,2023,10
  • [13] Shi Sai#, Xie Lei#, Ma Sen, Xu Binghong, An Hailong, Ye Sheng*, Wang Yaxin*, Computational and experimental studies of salvianolic acid A targets 3C protease to inhibit enterovirus 71 infection, Front. Pharmacol., 02 March 2023.
  • [14] Wang Yaxin#; Xu Binghong#; Ma Sen; Wang Hao; Shang Luqing; Zhu Cheng*; Ye Sheng*;Discovery of SARS-CoV-2 3CLPro Peptidomimetic Inhibitors through the Catalytic Dyad Histidine-Specific Prot ein–Ligand Interactions, International Journal of Molecular Sciences, 2022, 23
  • [15] Wu Xilin#; Wang Yaxin#; Cheng Lin#; Ni Fengfeng#; Zhu Linjing; Ma Sen; Huang bilian; Ji Mengmeng; Hu Huimin; Li Yuncheng; Xu Shijie; Shi Haixia; Zhang Dongdong; Liu Linshuo; Waqas Nawaz; HuQinxue; Ye Sheng*; Liu Yalan*; Wu Zhiwei*; Short-term instantaneous prophylaxis and efficient treatment against SARS-CoV-2 in hACE2 mice conferred by an intranasal nanobody (Nb22), Frontiers in Immunology, 2022
  • [16] Liu, Meijun#; Xu, Binghong; Ma, Yuying; Shang, Luqing*; Ye, Sheng*; Wang, Yaxin*; Reversible covalent inhibitors suppress enterovirus 71 infection by targeting the 3C protease, Antiviral Research, 2021, 192: 0-105102
  • [17] Binghong Xu#; Meijun Liu; Sen Ma; Yuying Ma; Si Liu; Luqing Shang; Cheng Zhu*; Sheng Ye*; Wangyaxin*; 4-Iminooxazolidin-2-One as a Bioisostere of Cyanohydrin Suppresses EV71 Proliferation by Targeting 3Cpro, Microbiology Spectrum, 2021, 9(3)
  • [18] Ma, Yuying#; Li, Linfeng; He, Shuai; Shang, Chengyou; Sun, Yang; Liu, Ning; Meek, Thomas D*; Wang, Yaxin*; Shang, Luqing*; Application of Dually Activated Michael Acceptor to the Rational Design of Reversible Covalent Inhibitor for Enterovirus 71 3C Protease, Journal of Medicinal Chemistry, 2019, 62(13): 6146-6162
  • [19] Wang Yaxin#, Liu Jingwei#, Cao Lin, Wang Wenjing, Sun Yuna, Yin Zheng, Lou Zhiyong*, Site-specific Incorporation of Chemical Fluorescence on Live Enterovirus-71 Virion by Organometallic Palladium Reagent to Monitor Virus Entry, Chembiochem. 2018,7,16;19(14):1465-1470
  • [20] Wang Yaxin#, Cao Lin, Zhai Yangyang, Yin Zheng, Sun Yuna, Shang Luqing*, Structure of the Enterovirus 71 3C Protease in Complex with NK-1.8k and Indications for the Development of Antienterovirus Protease, Antimicrob Agents Chemother, 2017,6,27;61(7):e00298-17.
  • [21] Wang Yaxin#, Cao Lin#, Zhai Yangyang, Ma Jiaming, Nie Quandeng, Li Ting, Yin Zheng, Sun Yuna*, Luqing Shang*, Inhibition of enterovirus 71 replication by an α-hydroxy-nitrile derivative NK-1.9k, Antiviral Res, 2017.5,141: 91-100
  • [22] Guo Yu#, Wang Yaxin#, Cao Lin, Wang Peng, Qing Jie, Zheng Qizhen, Shang Luqing, Yin Zheng*, Sun Yuna*, A conserved inhibitory mechanism of a lycorine derivative against enterovirus and hepatitis C virus, Antimicrob Agents Chemother, 2015,11,23;60(2):913-24.
  • [23] Wang Yaxin#, Yang Ben#, Zhai Yangyang, Yin Zheng*, Sun Yuna*, Rao Zihe, Peptidyl aldehyde NK-1.8k suppresses enterovirus 71 and enterovirus 68 infection by targeting protease 3C, Antimicrob Agents Chemother, 2015 5;59(5):2636-46.
  • [24] Shang Luqing#, Wang Yaxin#, Qing Jie, Shu Bo, Cao Lin, Lou Zhiyong, Gong Peng, Sun Yuna*, Yin Zheng*, An adenosine nucleoside analogue NITD008 inhibits EV71 proliferation, Antiviral Res, 2014,12;112:47-58.
  • [25] Qing Jie#, Wang Yaxin#, Sun Yuna#, Huang Jiaoyan, Yan Wenzhong, Wang Jinglan, Su Dan, Ni Cheng, Li Jian, Rao Zihe, Liu Lei*, Lou Zhiyong*, Cyclophilin A associates with enterovirus-71 virus capsid and plays an essential role in viral infection as an uncoating regulator, PLoS Pathog, 2014,10,2;10(10):e1004422
  • [26] Wang Yaxin#, Qing Jie#, Sun Yuna*, Rao Zihe*, Suramin inhibits EV71 infection, Antiviral Res, 2014,3;103:1-6.
  • [27] Chen Cheng#, Wang Yaxin#, Shan Chao#, Sun Yuna, Xu Peng, Zhou Honggang, Yang Cheng, Shi Pei-Yong, Rao Zihe, Zhang Bo*, Lou Zhiyong*, Crystal Structure of Enterovirus 71 RNA-Dependent RNA Polymerase Complexed with Its Protein Primer VPg: Implication for a trans Mechanism of VPg Uridylylation, J Virol, 2013,5;87(10):5755-68.
  • [28] Sun Yuna#, Wang Yaxin#, Shan Chao#, Chen Cheng, Xu Peng, Song Mohan, Zhou Honggang, Yang Cheng, Xu Wenbo, Shi Pei-Yong, Zhang Bo*, Lou Zhiyong*, Enterovirus 71 VPg uridylation uses a two-molecular mechanism of 3D polymerase, J Virol. 2012 12;86(24):13662-71.
  • [29] Zhai Yangyang#, Ma Yuying, Ma Fei, Nie Quandeng, Ren Xuejiao, Wang Yaxin, Shang Luqing*, Yin Zheng*, Structure-activity relationship study of peptidomimetic aldehydes as enterovirus 71 3C protease inhibitors, Eur J Med Chem. 2016 11 29;124:559-573.
  • [30] Han Zhiqiang#, Liang Xiao, Wang Yaxin, Qing Jie, Cao Lin, Shang Luqing*, Yin Zheng*, The discovery of indole derivatives as novel hepatitis C virus inhibitors, Eur J Med Chem. 2016 6 30;116:147-155
  • [31] Zeng Debin#, Ma Yuying, Zhang Rui, Nie Quandeng, Cui Zhengjie, Wang Yaxin, Shang Luqing*, Yin Zheng*, Synthesis and structure-activity relationship of α-keto amides as enterovirus 71 3C protease inhibitors, Bioorg Med Chem Lett. 2016 4 1;26(7):1762-6.
  • [32] Qing Jie#*, Luo Rui, Wang Yaxin, Nong Junxiu, Wu Ming, Shao Yan, Tang Ruoyi, Yu Xi, Yin Zheng, Sun Yuna*, Resistance analysis and characterization of NITD008 as an adenosine analog inhibitor against hepatitis C virus, Antiviral Res. 2016 2;126:43-54.
  • [33] Zhai Yangyang#, Zhao Xiangshuai, Cui Zhengjie, Wang Man, Wang Yaxin, Li Linfeng, Sun Qi, Yang Xi, Zeng Debin, Liu Ying, Sun Yuna, Lou Zhiyong, Shang Luqing*, Yin Zheng*, Cyanohydrin as an Anchoring Group for Potent and Selective Inhibitors of Enterovirus 71 3C Protease, J Med Chem. 2015 12 10;58(23):9414-20.
  • [34] Dang Minghao#, Wang Xiangxi, Wang Quan, Wang Yaxin, Lin Jianping, Sun Yuna, Li Xuemei, Zhang Liguo, Lou Zhiyong, Wang Junzhi, Rao Zihe*, Molecular mechanism of SCARB2-mediated attachment and uncoating of EV71, Protein Cell. 2014 9;5(9):692-703.

• Books
• [1] Some RNA Viruses, The causative agent of FMD disease

• Honors & Awards

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• [1] 2025年天津大学优秀硕士论文指导教师
• [2] Outstanding Mentor of Tianjin University 2025
• • [3] Outstanding Mentor of Tianjin University 2024
  • [4] Young backbone Teacher of Beiyang University