教育经历
· 2007.9 - 2013.6
ETH Zurich - Synthetic Biology - 博士 - Postdoctoral Synthetic Biology
· 2000.9 - 2002.6
University of Trento (Italy) - Physics - 博士 - Ph. D. Physics
· 1994.9 - 1999.6
University of Eastern Piedmont (Italy) - Physics - 硕士 - M.S. Physics
工作经历
· 2013.1 - 2018.1
哈尔滨工业大学  → Associate Professor in Synthetic Biology → Associate Professor in Synthetic Biology
· 2003.1 - 2007.12
CILEA (Italy)  → Analyst programmer → Analyst programmer
研究方向
· Overall, building genetic biosensors demands a proper characterization of its basic components and the optimization of mechanisms for the regulation, in yeast, of transcription and translation processes. These are two important research directions in my Synthetic Biology lab.
· Biosensors designed on the computer are implemented in my lab into the yeast S. cerevisiae. Yeast is the simplest eukaryotic organism and, as such, a perfect candidate to develop theoretical models and build biosensors that might be used later into more complex hosts such as mammalian cell
· Biosensors detect one or more chemicals (inputs) in the cellular environment and, as a response, trigger the production of a clear output signal (e.g. fluorescence) or the activation of a pathway that establishes an interaction between the cells and the sensed chemicals.
· On the computational side I am working on the development of a stand-alone piece of software for the design of biosensors in living cells.
· Research in Synthetic Biology is both theoretical and applied. Circuits are first designed on the computer. They are associated with mathematical models such that simulations can drive their wet-lab implementation.
· Synthetic Biology is referred to as Life Engineering since it aims at modifying cells with the insertion of DNA circuits that carry out new, specific tasks. Possible applications are diagnostics, cure of disease, biofuel production, and environmental care.
学术成果
论文成果
-
[2]CRISPR-Cas type II-based Synthetic Biology applications in eukaryotic cells
-
[3]Can terminators be used as insulator into yeast synthetic gene circuits?
-
[4]In silico design and in vivo implementation of yeast gene Boolean gates
-
[5]Modular, rule-based modeling for the design of eukaryotic synthetic gene circuits
-
[8]Computational design of synthetic gene circuits with composable parts