Gong Xiaoqun
School
School of Life Sciences
Professional Title
Professor
Discipline
纳米生物诊断与治疗技术
Contact Information
18822185423
gongxiaoqun@tju.edu.cn
No.92 Weijin Road, Nankai District, Tianjin, China
300072
Education Background
- Johns Hopkins University| 医学| 2012
- Master’s Degree| Tianjin University| School of Material Science and Engineering| 2009
- Doctoral degree| Tianjin University| Schoole of Material Science and Engineering| 2013
- Bachelor’s Degree| Tianjin University| School of Material Science and Engineering| 2007
Research Interests
- DNA存储新技术构建
- The thearpy of disease in the organs with mucus covered based on the mucus-penetrating nanoparticles。
- The detection of biomolecules(such as nucleic acid, protein) bsaed on the micro- and nano- technology;
Positions & Employments
-
生命科学学院 | 天津大学 | 学院党委委员 | 教授 
Academic Achievements
- Papers
- [1] 2023年
- [2] Yating Zhang, Shenghui Li, Kirsten Loch, Gregg A. Duncan, Logan Kaler, Rudra Pangeni,Weipan Peng, Sheng Wang,* Xiaoqun Gong,* and Qingguo Xu*,pH-Responsive Mucus-Penetrating Nanoparticles for Enhanced Cellular Internalization by Local Administration in Vaginal Tissue, ACS Macro Letters,2023, 12, 446−453.(一区,5.8)
-
- [3] Lin Su, Xiaoqun Gong*, Ruiyan Fan, Tianwen Ni, Fuhua Yang, Xiaomin Zhang a*, Xiaorong Li*, Mechanism of action of platinum nanoparticles implying from antioxidant to metabolic programming in light-induced retinal degeneration model, Redox Biology, 2023, 65:102836.(一区,11.4)
- [4] Zheng Wang, Jiaxun Wang, Jiacheng Liu, Yating Zhang, Jingyi Zhang, Ruimeng Yang, Zhaosong Meng*, Xiaoqun Gong*, Lei Sui*,Platinum nanoparticles enhance osteogenic differentiation of human dental follicle stem cells via scavenging ROS,Smart Materials in Medicine,2023,4: 621-638
- [5] 2022年
- [6] Weipan Peng, Shenghui Li, Yating zhang, Qiuting Zhang, Wenna Li, Houyu Han, Ran Luo, Jin Chang* , Xiaoqun Gong*,A Double DNAzyme-loaded MnO2 Versatile Nanodevice for Precise Cancer Diagnosis and Self-Sufficient Synergistic Gene Therapy,Chemical Engineering Journal, 2022, 450,:138138. (一区, IF=15.1)
- [7] Han Houyu, Cui jingyu, Zhou Dianming, Hua Deping, Lin Mengyao, Zhang yating, Li Fangya, Chang Jin, Gong Xiaoqun*, Zhang Jianyu*. Single-stranded RNA as primers of terminal deoxynucleotidyl transferase for template-independent DNA polymerization. Chinese Chemical Letters (2022). (二区, IF= 8.5)
- [8] Ran Luo, Guowei Lian, Hengxuan Li, Houyu Han, Dianming Zhou, Xiaoqun Gong*. Ultrasensitive sensing of T4 PNK phosphatase activity through establishing a novel transcription-based signal amplification platform. Sensors and Actuators: B. Chemical, 2022, 369:132269. (二区, IF= 9.2)
- [9] Wenna Li, Weipan Peng, Yating Zhang, Ping Liu, Xiaoqun Gong*, Hao Liu*, Jin Chang*, A lateral flow strip biosensor platform based on cascade nucleic acid amplification technology for ultrasensitive detection of OSCC-associated salivary MicroRNA. Analytica Chimica Acta, 2022, 1221:340112. (二区, IF= 6.9)
- [10] 2021年
- [11] Weipan Peng #, Xiaoqun Gong*, Dianming Zhou, Wenna Li, Minghui Chen, Guowei Lian, Jin Chang*, and Tao Wang*. MicroRNA-Responsive DNA-Programmed Nanomedicine with Controllability of Cascaded Events for Cancer Therapy Enhancement.2021,10,654-661,ACS Macro Letters(二区, IF=7.0)
- [12] Hengxuan Li, Minghui Chen, Ran Luo, Weipan Peng, Xiaoqun Gong*, Jin Chang*.An Amplified Fluorescent Biosensor for Ag+ Detection through the Hybridization Chain Reactions, Colloids and Surfaces B: Biointerfaces, 2021, 202: 111686. (二区, IF= 5.9)
- [13] Lu Li,Shenghui Li, Sheng Wang , Xiaoli Xing, Yating Zhang, Lin Su, Xiaoli Wu, Hanjie Wang, Jin Chang*, Xiaoqun Gong*, Antioxidant and anti-glycated TAT-modified platinum nanoclusters as eye drops for non-invasive and painless relief of diabetic cataract in rats. Chemical Engineering Journal, 2020, 398:125436. (一区, IF= 13.65)
- [14] Minghui Chen, Hengxuan Li, Zhihonng Shi, Xiyu Li, Weipan Peng, Yi Qin , Guowei Lian, Dianming Zhou, Xiaoqun Gong*, Jin Chang*. High Fluorescence Quenching Probe-Based Reverse Fluorescence Enhancement LFTS Coupling with IS-primer Amplification Reaction for the Rapid and Sensitive Parkinson Disease-associated MicroRNA Detection, Biosensors & Biolelectronics, 2020, 165:112278. (一区, IF=10.25)
- [15] Weipan Peng; Yi Qin; Wenna Li; Minghui Chen; Dianming Zhou; Hengxuan Li; Jingyu Cui; Jin Chang*; Sheng Xie*; Xiaoqun Gong*; Benzhong Tang. Nonenzyme Cascaded Amplification Biosensor Based on Effective Aggregation Luminescence Caused by Disintegration of Silver Nanoparticles. ACS sensors,2020, 5(7):1912-1920(一区, IF=7.3)
- [16] Jingyu Cui; Houyu Han; Jiafang Piao; Hai Shi; Dianming Zhou; Xiaoqun Gong*; Jin Chang* The construction of a novel biosensor based on the dual-enzyme cascade amplification-induced copper nanoparticles self-assembly for ultrasensitive detection of microRNA153. ACS Applied Materials & Interfaces,2020,12(30):34130-34136. (一区, IF= 8.7)
- [17] Minghui Chen, Ran Luo, Shenghui Li, Hengxuan Li, Yi Qin, Dianming Zhou,* Hao Liu, Xiaoqun Gong*, and Jin Chang*,Paper-Based Strip for Ultrasensitive Detection of OSCC-Associated Salivary MicroRNA via CRISPR/Cas12a Coupling with IS-Primer Amplification Reaction. Analytical chemistry,2020,92,13336-13342. (一区, IF= 8.7)
- [18] Weipan Peng, Qian Zhao, Minghui Chen, Jiafang Piao, Weichen Gao, Xiaoqun Gong*, Jin Chang*,An innovative “unlocked mechanism” by a double key avenue for one-pot detection of microRNA-21 and microRNA-141, Theranostics, 2019,9(1):279-289.(一区, IF= 11.3)
- [19] Dianming Zhou, Xiaohui Lin, Weichen Gao, Jiafang Piao, Shufei Li, Ning He, Zhiyong Qian*, Miao Zhao, Xiaoqun Gong*. A novel template repairing-PCR (TR-PCR) reaction platform for microRNA detection using translesional synthesis on DNA templates containing abasic site, Chemical Communication, 2019, 55, 2932-2935.(一区, IF= 6.29)
- [20] Yurui Zhou, Lu Li, Shenghui Li, Shufei Li, Miao Zhao, Qinghong Zhou, Xiaoqun Gong*, Jin Yang* and Jin Chang*. Autoregenerative redox nanoparticles as an antioxidant and glycation inhibitor for palliation of diabetic cataracts, Nanoscale, 2019, 11, 13126. (一区, IF= 6.9)
- [21] Minghui Chen#, Hengxuan Li#, Dianming Zhou, Weipan Peng , Jiafang Piao , Weichen Gao, Xiaoqun Gong*, Jin Chang*. Reusable Bioluminescent Sensor for Ultrasensitive MicroRNA Detection Based on a Target-Introducing “Fuel-Loading” Mechanism. ACS Applied Materials & Interfaces, 2019, 11, 38586−38594. (一区, IF=7.50)
- [22] Weipan Peng#, Yiwen Huang#, Qian Zhao, Guowei Lian, Minghui Chen, Jiafang Piao, Xiaoqun Gong*, Jin Chang*. A fluorescent signal “removal” sensor via duplex-specific nuclease-aided cleavage for miRNA detection in flow cytometry. Colloids and Surfaces B: Biointerfaces, 2020,185:110570(二区, )
- [23] Weipan Peng, Qian Zhao, Jiafang Piao, Miao Zhao, Yiwen Huang, Bo Zhang, Weichen Gao, Dianming Zhou, Guiming Shu, Xiaoqun Gong*, Jin Chang*. Ultra-sensitive detection of microRNA-21 based on duplex-specific nuclease-assisted target recycling and horseradish peroxidase cascading signal amplification. Sensors and Actuators B- Chemical, 2018, 263(15): 289-297. (一区, IF=5.667)
- [24] Qian Zhao, Jiafang Piao, Weipan Peng, Yang Wang, Bo Zhang, Xiaoqun Gong*, and Jin Chang*.Simple and Sensitive Quantification of MicroRNAs via PS@Au Microspheres-Based DNA Probes and DSN-Assisted Signal Amplification Platform. ACS Applied Materials & Interfaces, 2018, 10 (4):3324–3332. (一区, IF=8.10)
- [25] Xiaoqun Gong, Bo Zhang, Jiafang Piao, Qian Zhao, Weichen Gao, Weipan Peng, Qi Kang*, Dianming Zhou, Guiming Shu and Jin Chang*. High sensitive and multiple detection of Acute Myocardial Infarction Biomarkers based on a dual-readout Immunochromatography Test Strip. Nanomedicine: Nanotechnology Biology & Medicine. 2018, 14:1257–1266. (一区, IF=6.50)
- [26] Bo Zhang, Weichen Gao, Jiafang Piao, Yunjie Xiao, Bin Wang, Weipan Peng, Xiaoqun Gong*, Zefang Wang *, Haitao Yang and Jin Chang*, Effective Bioactivity Retention of Low-Concentration Antibodies on HFBI-Modified Fluorescence ICTS for Sensitive and Rapid Detection of PSA. ACS Applied Materials & Interfaces, 2018, 10 (17): 14549–14558. (一区, IF=7.50)
- [27] Qian Zhao, Jiafang Piao, Weipan Peng, Jun wang, Weichen Gao, Xiaoqun Gong*, Bingbo Zhang and Jin Chang*, A Metal Chelator as a Plasmonic Signal-Generation Superregulator for Ultrasensitive Colorimetric Bioassays of Disease Biomarkers, Advanced Science, 2018, 2018, 5(7): 1800295.(一区, IF=16.4)
- [28] Jiafang Piao, Qian Zhao, Dianming Zhou, Weipan Peng, Weichen Gao, Minghui Chen, Guiming Shu, Xiaoqun Gong*, Jin Chang*, Enzyme-free Colorimetric Detection of MicroRNA-21 Using Metal Chelator as Label for Signal Generation and Amplification, Analytica Chimica Acta, 2019, 1052:145-152. (二区,IF=5.12)
- [29] Jin Yang#, Xiaoqun Gong#, Lei Fang, Qi Fan, Lei Cai, Xiaodi Qiu, Bo Zhang, Jin Chang, Yi Lu*. Potential of CeCl3@mSiO2 Nanoparticles in Alleviating Diabetic Cataract Development and Progression. Nanomedicine Nanotechnology Biology & Medicine, 2017, 13(3):1147-1151. (一区, IF=5.72)
- [30] Lei Fang, Lingwei Wang, Yingyi Yao, Jian Zhang, Xiaoli Wu, Xue Li, Hanjie Wang, Xuening Zhang, Xiaoqun Gong*, Jin Chang*. Micro- and nano-carrier systems: the non-invasive and painless local administration strategies for disease therapy in mucosal tissues. Nanomedicine: Nanotechnology Biology & Medicine. 2017,13:153–171. (一区, IF=5.72)
- [31] Bo Zhang, Wenjuan Ma, Fuxin Li, Weichen Gao, Qian Zhao, Weipan Peng, Jiafang Piao, Xiaoli Wu, Hanjie Wang, Xiaoqun Gong* and Jin Chang*.Fluorescence quenching-based signal amplification on immunochromatography test strips for dual-mode sensing of two biomarkers of breast cancer. Nanoscale, 2017, 9(47):18711-18722. (一区, IF=7.36)
- [32] Yudong Wu, Weisheng Guo, Weipan Peng, Qian Zhao, Jiafang Piao, Bo Zhang, Xiaoli Wu, Hanjie Wang, Xiaoqun Gong*, and Jin Chang*. Enhanced Fluorescence ELISA Based on HAT Triggering Fluorescence “Turn-on” with Enzyme-Antibody Dual Labeled AuNP Probes for Ultrasensitive Detection of AFP and HBsAg. ACS Applied Materials & Interfaces, 2017, 9 (11):9369–9377. (一区, IF=7.50)
- [33] Jian Zhang, Qian Zhao, Yudong Wu, Bo Zhang, Weipan Peng, Jiafang Piao, Yurui Zhou, Weichen Gao, Xiaoqun Gong* and Jin Chang *. The Construction of a Novel Nucleic Acids Detection Microplatform Based on the NSET for One-step Detecting TK1-DNA and MicroRNA-21. Biosensors and Bioelectronics, 2017, 97(15):26–33. (一区, IF=10.25)
- [34] Xiaoqun Gong, Jin Cai, Bo Zhang, Qian Zhao, Jiafang Piao, Weipan Peng, Weichen Gao, Dianming Zhou, Miao Zhao, Jin Chang. A review of fluorescent signal-based lateral flow immunochromatographic strips. Journal of Materials Chemistry B, 2017, 5, 5079-5091. (一区,IF: 4.54)
- [35] Yingyi Yao, Weisheng Guo, Jian Zhang, Yudong Wu, Weihua Fu, Tingting Liu, Xiaoli Wu, Hanjie Wang, Xiaoqun Gong*, Xing-jie Liang, and Jin Chang*. Reverse fluorescence enhancement and colorimetric bimodal signal readout immunochromatography test strip for ultrasensitive large-scale screening and postoperative monitoring. ACS Applied Materials & Interfaces, 2016, 8(35): 22963-22970. (一区, IF=7.50)
- [36] Sheng Wang, Weitao Yang, Hongli Du, Fangfang Guo, Hanjie Wang, Jin Chang*, Xiaoqun Gong*, Bingbo Zhang. Multifunctional reduction-responsive SPIO&DOX-loaded PEGylated polymeric lipid vesicles for magnetic resonance imaging-guided drug delivery. Nanotechnology, 2016, 26(16):165101. SCI (二区,IF= 3.57)
- [37] Qian Zhao, Huan Yan, Ping Liu, Yingyi Yao, Yudong Wu, Jian Zhang, Hengxuan Li, Xiaoqun Gong*, Jin Chang*. An ultra-sensitive and colorimetric sensor for copper and iron based on glutathione-functionalized gold nanoclusters nanoclusters. Analytica Chimica Acta, 2016, 948: 73-79. (二区,IF= 4.95)
- [38] Xiaoqun Gong#, Huan Yan#, Jiumin Yang, Yudong Wu, Jian Zhang, Yingyi Yao, Ping Liu, Huiquan Wang, Zhidong Hu, Jin Chang. High-performance fluorescence-encoded magnetic microbeads as microfluidic protein chip supports for AFP detection. Analytica Chimica Acta, 2016, 939: 84-92. (二区,IF= 4.95)
- [39] Lingwei Wang#, Yurui Zhou#, Menglin Wu, Minghao Wu, Xue Li, Xiaoqun Gong*, Jin Chang, Xuening Zhang*. Functional nanocarrier for drug and gene delivery via local administration in mucosal tissues,Nanomedicine, 2018 , 13(1):69-88. (二区, IF=4.72)
- [40] Cui Ye#, Gong Xiaoqun#, Zhu Shengjiang, Li Yunhong, Sun Wenya, YangQiuhua, Chang Jin(*). An effective modified method to prepare highly luminescent, highly stable water-soluble quantum dots and its preliminary application in immunoassay, Journal of Materials Chemistry, 2011, 22(2):462-469. SCI (一区,IF: 4.54)
- [41] Xiaoqun Gong, Qi Zhang, Ye Cui, Shengjiang Zhu, Wenya Su, Qiuhua Yang, Jin Chang *. A facile method to prepare high-performance magnetic and fluorescent bifunctional nanocomposites and their preliminary application in biomolecule detection. Journal of Materials Chemistry B, 2013, 1(15):2098-2106. (一区,IF: 4.54)
- [42] Wentao Yang, Weisheng Guo, Tingbin Zhang, Weitao Yang, Lin Su, Lei Fang, Hanjie Wang, Xiaoqun Gong*, Jin Chang*. Synthesis of aqueousAg In S/ZnS@PEI as a self-indicating nonviral vector for plasmid DNA self-trackingdelivery. Journal of Materials Chemistry B, 2015, 3: 8518-8527. SCI(一区,IF: 4.54)
- Honors & Awards
- [1] 2020年天津大学优秀硕士学位论文指导教师
- [2] 2019年沈志康奖教金,天津大学青年教工示范岗