Gong Xiaoqun
School
School of Life Sciences
Professional Title
Associate professor
Discipline
纳米生物诊断与治疗技术
Contact Information
gongxiaoqun@tju.edu.cn
No.92 Weijin Road, Nankai District, Tianjin, China
300072
Brief Introduction
Xiaoqun Gong was born in 1984. She obtained her B.S., M.Sc. and Ph.D. degree all from Tianjin University, China, and as a visiting student, she studied in John Hopkins University for one year. Now, she is an assistant professor in School of Life Sciences in Tianjin University. Her research interest is focused on nanoparticels preparation for biomolecules detection and drug delivery. Currently, she particularly contributes her research to the
biosensors and controlled drug release. She published about 40 papers and has 3 patents.
Education Background
- Johns Hopkins University| 医学| 2012
- Master’s Degree| Tianjin University| School of Material Science and Engineering| 2009
- Doctoral degree| Tianjin University| Schoole of Material Science and Engineering| 2013
- Bachelor’s Degree| Tianjin University| School of Material Science and Engineering| 2007
Research Interests
- The thearpy of disease in the organs with mucus covered based on the mucus-penetrating nanoparticles。
- The detection of biomolecules(such as nucleic acid, protein) bsaed on the micro- and nano- technology;
Positions & Employments
-
2018.6-Now
生命科学学院 | 天津大学 | 支部书记 | 副教授 -
2013.9-2019.12
School of life sciences | Tianjin University
Academic Achievements
- Papers
- [1] 2023年
- [2] Yating Zhang, Shenghui Li, Kirsten Loch, Gregg A. Duncan, Logan Kaler, Rudra Pangeni,Weipan Peng, Sheng Wang,* Xiaoqun Gong,* and Qingguo Xu*,pH-Responsive Mucus-Penetrating Nanoparticles for Enhanced Cellular Internalization by Local Administration in Vaginal Tissue, ACS Macro Letters,2023, 12, 446−453.（一区，5.8）
-
- [3] Lin Su, Xiaoqun Gong*, Ruiyan Fan, Tianwen Ni, Fuhua Yang, Xiaomin Zhang a*, Xiaorong Li*， Mechanism of action of platinum nanoparticles implying from antioxidant to metabolic programming in light-induced retinal degeneration model, Redox Biology, 2023, 65:102836.（一区，11.4）
- [4] Zheng Wang, Jiaxun Wang, Jiacheng Liu, Yating Zhang, Jingyi Zhang, Ruimeng Yang, Zhaosong Meng*, Xiaoqun Gong*, Lei Sui*，Platinum nanoparticles enhance osteogenic differentiation of human dental follicle stem cells via scavenging ROS，Smart Materials in Medicine，2023,4: 621-638
- [5] 2022年
- [6] Weipan Peng, Shenghui Li, Yating zhang, Qiuting Zhang, Wenna Li, Houyu Han, Ran Luo, Jin Chang* , Xiaoqun Gong*，A Double DNAzyme-loaded MnO2 Versatile Nanodevice for Precise Cancer Diagnosis and Self-Sufficient Synergistic Gene Therapy，Chemical Engineering Journal, 2022, 450,：138138. （一区， IF=15.1）
- [7] Han Houyu, Cui jingyu, Zhou Dianming, Hua Deping, Lin Mengyao, Zhang yating, Li Fangya, Chang Jin, Gong Xiaoqun*, Zhang Jianyu*. Single-stranded RNA as primers of terminal deoxynucleotidyl transferase for template-independent DNA polymerization. Chinese Chemical Letters (2022). （二区， IF= 8.5）
- [8] Ran Luo, Guowei Lian, Hengxuan Li, Houyu Han, Dianming Zhou, Xiaoqun Gong*. Ultrasensitive sensing of T4 PNK phosphatase activity through establishing a novel transcription-based signal amplification platform. Sensors and Actuators: B. Chemical, 2022, 369:132269. （二区， IF= 9.2）
- [9] Wenna Li, Weipan Peng, Yating Zhang, Ping Liu, Xiaoqun Gong*, Hao Liu*, Jin Chang*, A lateral flow strip biosensor platform based on cascade nucleic acid amplification technology for ultrasensitive detection of OSCC-associated salivary MicroRNA. Analytica Chimica Acta, 2022, 1221:340112. （二区， IF= 6.9）
- [10] 2021年
- [11] Weipan Peng #, Xiaoqun Gong*, Dianming Zhou, Wenna Li, Minghui Chen, Guowei Lian, Jin Chang*, and Tao Wang*. MicroRNA-Responsive DNA-Programmed Nanomedicine with Controllability of Cascaded Events for Cancer Therapy Enhancement.2021,10,654-661,ACS Macro Letters（二区， IF=7.0）
- [12] Hengxuan Li, Minghui Chen, Ran Luo, Weipan Peng, Xiaoqun Gong*, Jin Chang*.An Amplified Fluorescent Biosensor for Ag+ Detection through the Hybridization Chain Reactions, Colloids and Surfaces B: Biointerfaces, 2021, 202: 111686. （二区， IF= 5.9）
- [13] Lu Li，Shenghui Li, Sheng Wang , Xiaoli Xing, Yating Zhang, Lin Su, Xiaoli Wu, Hanjie Wang, Jin Chang*, Xiaoqun Gong*, Antioxidant and anti-glycated TAT-modified platinum nanoclusters as eye drops for non-invasive and painless relief of diabetic cataract in rats. Chemical Engineering Journal, 2020, 398:125436. （一区， IF= 13.65）
- [14] Minghui Chen, Hengxuan Li, Zhihonng Shi, Xiyu Li, Weipan Peng, Yi Qin , Guowei Lian, Dianming Zhou, Xiaoqun Gong*, Jin Chang*. High Fluorescence Quenching Probe-Based Reverse Fluorescence Enhancement LFTS Coupling with IS-primer Amplification Reaction for the Rapid and Sensitive Parkinson Disease-associated MicroRNA Detection, Biosensors & Biolelectronics, 2020, 165:112278. （一区， IF=10.25）
- [15] Weipan Peng; Yi Qin; Wenna Li; Minghui Chen; Dianming Zhou; Hengxuan Li; Jingyu Cui; Jin Chang*; Sheng Xie*; Xiaoqun Gong*; Benzhong Tang. Nonenzyme Cascaded Amplification Biosensor Based on Effective Aggregation Luminescence Caused by Disintegration of Silver Nanoparticles. ACS sensors,2020, 5(7):1912-1920（一区， IF=7.3）
- [16] Jingyu Cui; Houyu Han; Jiafang Piao; Hai Shi; Dianming Zhou; Xiaoqun Gong*; Jin Chang* The construction of a novel biosensor based on the dual-enzyme cascade amplification-induced copper nanoparticles self-assembly for ultrasensitive detection of microRNA153. ACS Applied Materials & Interfaces,2020,12(30):34130-34136. （一区， IF= 8.7）
- [17] Minghui Chen, Ran Luo, Shenghui Li, Hengxuan Li, Yi Qin, Dianming Zhou,* Hao Liu, Xiaoqun Gong*, and Jin Chang*，Paper-Based Strip for Ultrasensitive Detection of OSCC-Associated Salivary MicroRNA via CRISPR/Cas12a Coupling with IS-Primer Amplification Reaction. Analytical chemistry,2020,92,13336-13342. （一区， IF= 8.7）
- [18] Weipan Peng, Qian Zhao, Minghui Chen, Jiafang Piao, Weichen Gao, Xiaoqun Gong*, Jin Chang*，An innovative “unlocked mechanism” by a double key avenue for one-pot detection of microRNA-21 and microRNA-141, Theranostics, 2019,9(1):279-289.（一区， IF= 11.3）
- [19] Dianming Zhou, Xiaohui Lin, Weichen Gao, Jiafang Piao, Shufei Li, Ning He, Zhiyong Qian*, Miao Zhao, Xiaoqun Gong*. A novel template repairing-PCR (TR-PCR) reaction platform for microRNA detection using translesional synthesis on DNA templates containing abasic site, Chemical Communication, 2019, 55, 2932-2935.（一区， IF= 6.29）
- [20] Yurui Zhou, Lu Li, Shenghui Li, Shufei Li, Miao Zhao, Qinghong Zhou, Xiaoqun Gong*, Jin Yang* and Jin Chang*. Autoregenerative redox nanoparticles as an antioxidant and glycation inhibitor for palliation of diabetic cataracts, Nanoscale, 2019, 11, 13126. （一区， IF= 6.9）
- [21] Minghui Chen#, Hengxuan Li#, Dianming Zhou, Weipan Peng , Jiafang Piao , Weichen Gao, Xiaoqun Gong*, Jin Chang*. Reusable Bioluminescent Sensor for Ultrasensitive MicroRNA Detection Based on a Target-Introducing “Fuel-Loading” Mechanism. ACS Applied Materials & Interfaces, 2019, 11, 38586−38594. （一区， IF=7.50）
- [22] Weipan Peng#, Yiwen Huang#, Qian Zhao, Guowei Lian, Minghui Chen, Jiafang Piao, Xiaoqun Gong*, Jin Chang*. A fluorescent signal “removal” sensor via duplex-specific nuclease-aided cleavage for miRNA detection in flow cytometry. Colloids and Surfaces B: Biointerfaces, 2020,185:110570（二区， ）
- [23] Weipan Peng, Qian Zhao, Jiafang Piao, Miao Zhao, Yiwen Huang, Bo Zhang, Weichen Gao, Dianming Zhou, Guiming Shu, Xiaoqun Gong*, Jin Chang*. Ultra-sensitive detection of microRNA-21 based on duplex-specific nuclease-assisted target recycling and horseradish peroxidase cascading signal amplification. Sensors and Actuators B- Chemical, 2018, 263(15): 289-297. （一区， IF=5.667）
- [24] Qian Zhao, Jiafang Piao, Weipan Peng, Yang Wang, Bo Zhang, Xiaoqun Gong*, and Jin Chang*.Simple and Sensitive Quantification of MicroRNAs via PS@Au Microspheres-Based DNA Probes and DSN-Assisted Signal Amplification Platform. ACS Applied Materials & Interfaces, 2018, 10 (4):3324–3332. （一区， IF=8.10）
- [25] Xiaoqun Gong, Bo Zhang, Jiafang Piao, Qian Zhao, Weichen Gao, Weipan Peng, Qi Kang*, Dianming Zhou, Guiming Shu and Jin Chang*. High sensitive and multiple detection of Acute Myocardial Infarction Biomarkers based on a dual-readout Immunochromatography Test Strip. Nanomedicine: Nanotechnology Biology & Medicine. 2018, 14:1257–1266. （一区， IF=6.50）
- [26] Bo Zhang, Weichen Gao, Jiafang Piao, Yunjie Xiao, Bin Wang, Weipan Peng, Xiaoqun Gong*, Zefang Wang *, Haitao Yang and Jin Chang*, Effective Bioactivity Retention of Low-Concentration Antibodies on HFBI-Modified Fluorescence ICTS for Sensitive and Rapid Detection of PSA. ACS Applied Materials & Interfaces, 2018, 10 (17): 14549–14558. （一区， IF=7.50）
- [27] Qian Zhao, Jiafang Piao, Weipan Peng, Jun wang, Weichen Gao, Xiaoqun Gong*, Bingbo Zhang and Jin Chang*, A Metal Chelator as a Plasmonic Signal-Generation Superregulator for Ultrasensitive Colorimetric Bioassays of Disease Biomarkers, Advanced Science, 2018， 2018, 5(7): 1800295.（一区， IF=16.4）
- [28] Jiafang Piao, Qian Zhao, Dianming Zhou, Weipan Peng, Weichen Gao, Minghui Chen, Guiming Shu, Xiaoqun Gong*, Jin Chang*, Enzyme-free Colorimetric Detection of MicroRNA-21 Using Metal Chelator as Label for Signal Generation and Amplification, Analytica Chimica Acta, 2019, 1052:145-152. (二区，IF=5.12)
- [29] Jin Yang#, Xiaoqun Gong#, Lei Fang, Qi Fan, Lei Cai, Xiaodi Qiu, Bo Zhang, Jin Chang, Yi Lu*. Potential of CeCl3@mSiO2 Nanoparticles in Alleviating Diabetic Cataract Development and Progression. Nanomedicine Nanotechnology Biology & Medicine, 2017, 13(3):1147-1151. （一区， IF=5.72）
- [30] Lei Fang, Lingwei Wang, Yingyi Yao, Jian Zhang, Xiaoli Wu, Xue Li, Hanjie Wang, Xuening Zhang, Xiaoqun Gong*, Jin Chang*. Micro- and nano-carrier systems: the non-invasive and painless local administration strategies for disease therapy in mucosal tissues. Nanomedicine: Nanotechnology Biology & Medicine. 2017,13:153–171. （一区， IF=5.72）
- [31] Bo Zhang, Wenjuan Ma, Fuxin Li, Weichen Gao, Qian Zhao, Weipan Peng, Jiafang Piao, Xiaoli Wu, Hanjie Wang, Xiaoqun Gong* and Jin Chang*.Fluorescence quenching-based signal amplification on immunochromatography test strips for dual-mode sensing of two biomarkers of breast cancer. Nanoscale, 2017, 9(47):18711-18722. （一区， IF=7.36）
- [32] Yudong Wu, Weisheng Guo, Weipan Peng, Qian Zhao, Jiafang Piao, Bo Zhang, Xiaoli Wu, Hanjie Wang, Xiaoqun Gong*, and Jin Chang*. Enhanced Fluorescence ELISA Based on HAT Triggering Fluorescence “Turn-on” with Enzyme-Antibody Dual Labeled AuNP Probes for Ultrasensitive Detection of AFP and HBsAg. ACS Applied Materials & Interfaces, 2017, 9 (11)：9369–9377. （一区， IF=7.50）
- [33] Jian Zhang, Qian Zhao, Yudong Wu, Bo Zhang, Weipan Peng, Jiafang Piao, Yurui Zhou, Weichen Gao, Xiaoqun Gong* and Jin Chang *. The Construction of a Novel Nucleic Acids Detection Microplatform Based on the NSET for One-step Detecting TK1-DNA and MicroRNA-21. Biosensors and Bioelectronics, 2017, 97(15):26–33. （一区， IF=10.25）
- [34] Xiaoqun Gong, Jin Cai, Bo Zhang, Qian Zhao, Jiafang Piao, Weipan Peng, Weichen Gao, Dianming Zhou, Miao Zhao, Jin Chang. A review of fluorescent signal-based lateral flow immunochromatographic strips. Journal of Materials Chemistry B, 2017, 5, 5079-5091. (一区，IF: 4.54)
- [35] Yingyi Yao, Weisheng Guo, Jian Zhang, Yudong Wu, Weihua Fu, Tingting Liu, Xiaoli Wu, Hanjie Wang, Xiaoqun Gong*, Xing-jie Liang, and Jin Chang*. Reverse fluorescence enhancement and colorimetric bimodal signal readout immunochromatography test strip for ultrasensitive large-scale screening and postoperative monitoring. ACS Applied Materials & Interfaces, 2016, 8(35): 22963-22970. （一区， IF=7.50）
- [36] Sheng Wang, Weitao Yang, Hongli Du, Fangfang Guo, Hanjie Wang, Jin Chang*, Xiaoqun Gong*, Bingbo Zhang. Multifunctional reduction-responsive SPIO&DOX-loaded PEGylated polymeric lipid vesicles for magnetic resonance imaging-guided drug delivery. Nanotechnology, 2016, 26(16):165101. SCI (二区，IF= 3.57)
- [37] Qian Zhao, Huan Yan, Ping Liu, Yingyi Yao, Yudong Wu, Jian Zhang, Hengxuan Li, Xiaoqun Gong*, Jin Chang*. An ultra-sensitive and colorimetric sensor for copper and iron based on glutathione-functionalized gold nanoclusters nanoclusters. Analytica Chimica Acta, 2016, 948: 73-79. (二区，IF= 4.95)
- [38] Xiaoqun Gong#, Huan Yan#, Jiumin Yang, Yudong Wu, Jian Zhang, Yingyi Yao, Ping Liu, Huiquan Wang, Zhidong Hu, Jin Chang. High-performance fluorescence-encoded magnetic microbeads as microfluidic protein chip supports for AFP detection. Analytica Chimica Acta, 2016, 939: 84-92. (二区，IF= 4.95)
- [39] Lingwei Wang#, Yurui Zhou#, Menglin Wu, Minghao Wu, Xue Li, Xiaoqun Gong*, Jin Chang, Xuening Zhang*. Functional nanocarrier for drug and gene delivery via local administration in mucosal tissues，Nanomedicine, 2018 , 13(1):69-88. （二区， IF=4.72）
- [40] Cui Ye#, Gong Xiaoqun#, Zhu Shengjiang, Li Yunhong, Sun Wenya, YangQiuhua, Chang Jin(*). An effective modified method to prepare highly luminescent, highly stable water-soluble quantum dots and its preliminary application in immunoassay, Journal of Materials Chemistry, 2011, 22(2):462-469. SCI (一区，IF: 4.54)
- [41] Xiaoqun Gong, Qi Zhang, Ye Cui, Shengjiang Zhu, Wenya Su, Qiuhua Yang, Jin Chang *. A facile method to prepare high-performance magnetic and fluorescent bifunctional nanocomposites and their preliminary application in biomolecule detection. Journal of Materials Chemistry B, 2013, 1(15):2098-2106. (一区，IF: 4.54)
- [42] Wentao Yang, Weisheng Guo, Tingbin Zhang, Weitao Yang, Lin Su, Lei Fang, Hanjie Wang, Xiaoqun Gong*, Jin Chang*. Synthesis of aqueousAg In S/ZnS@PEI as a self-indicating nonviral vector for plasmid DNA self-trackingdelivery. Journal of Materials Chemistry B, 2015, 3: 8518-8527. SCI(一区，IF: 4.54)
- Honors & Awards
- [1] 2020年天津大学优秀硕士学位论文指导教师
- [2] 2019年沈志康奖教金，天津大学青年教工示范岗